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Cell Biology for Immune Evasion: Organizing Antigenic Variation, Surfaces, Trafficking, and Cellular Structures in Trypanosoma brucei

  • Ka Fai Leung
  • Paul T. Manna
  • Cordula Boehm
  • Luke Maishman
  • Mark C. FieldEmail author
Chapter

Abstract

For any pathogen to maintain an infection for a protracted period, there is a necessity for precise adaptation to the host environment to avoid the twin perils of elimination by the host defense system or by death of the host from a fatal impact on host physiology. There is also a need to maintain a sufficiently robust infection, and hence cell number, so that the probability of transmission is maximized, but again avoiding overwhelming host resources. For African trypanosomes, which, in the case of Trypanosoma brucei gambiense, can survive within certain mammalian hosts for many years or even decades, these constraints are clearly very well met. Here we will consider several cellular systems and current thinking on how these contribute toward immune evasion and survival; specific areas are maintaining the parasite surface proteome, motility, and control of gene expression of virulence-associated surface molecules. Our focus is essentially restricted to African trypanosomes, due in part to the overwhelmingly greater understanding we have of the cell biology of these trypanosomatids.

Keywords

Endomembrane System Expression Site Flagellar Pocket Procyclic Form African Trypanosome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Work in our laboratory is supported by a program grant from the Wellcome Trust (082813 to MCF) and project grants from the MRC (MR/K008749/1 to MCF). LM is supported by a Cambridge Gates studentship.

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Copyright information

© Springer-Verlag Wien 2014

Authors and Affiliations

  • Ka Fai Leung
    • 1
  • Paul T. Manna
    • 1
  • Cordula Boehm
    • 1
  • Luke Maishman
    • 1
  • Mark C. Field
    • 1
    Email author
  1. 1.Department of PathologyUniversity of CambridgeCambridgeUK

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