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Sphingolipids in Disease pp 457–467Cite as

Role of Sphingosine 1-Phosphate in Skeletal Muscle Cell Biology

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 216))

Abstract

Studies performed in the last fifteen years have clearly established that the bioactive sphingolipid sphingosine 1-phosphate (S1P) affects various different biological properties of myogenic precursor cells as well as physiological features of adult skeletal muscle. Noticeably, in myogenic precursor cells multiple growth factors and cytokines cross-communicate with S1P axis and the engagement of distinct S1P receptor subtypes appears to be crucially implicated in transmitting specific biological effects. This paper summarizes current research findings and discloses the potential for new therapeutics designed to alter S1P signaling with the aim of improving skeletal muscle repair.

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Authors and Affiliations

  1. Dipartimento di Scienze Biochimiche, Sperimentali e Cliniche, Università di Firenze, Viale GB Morgagni 50, 50134, Firenze, Italy

    Paola Bruni & Chiara Donati

Authors
  1. Paola Bruni
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  2. Chiara Donati
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Correspondence to Paola Bruni .

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Editors and Affiliations

  1. , Department of Molecular Biology, University of Duisburg-Essen, Hufelandstraße 55, Essen, 45122, Germany

    Erich Gulbins

  2. Division of Pulmonary, Allergy, Critical, Department of Medicine, Indiana University School of Medicine, W. Walnut Street 980, Indianapolis, 46202, Indiana, USA

    Irina Petrache

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Bruni, P., Donati, C. (2013). Role of Sphingosine 1-Phosphate in Skeletal Muscle Cell Biology. In: Gulbins, E., Petrache, I. (eds) Sphingolipids in Disease. Handbook of Experimental Pharmacology, vol 216. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1511-4_23

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