The Impact of Multichannel Microelectrode Recording (MER) in Deep Brain Stimulation of the Basal Ganglia

  • Thomas M. KinfeEmail author
  • Jan Vesper
Conference paper
Part of the Acta Neurochirurgica Supplement book series (NEUROCHIRURGICA, volume 117)


Deep brain stimulation (DBS) of the basal ganglia (Ncl. subthalamicus, Ncl. ventralis intermedius thalami, globus pallidus internus) has become an evidence-based and well-established treatment option in otherwise refractory movement disorders. The Ncl. subthalamicus (STN) is the target of choice in Parkinson’s disease.

However, a considerable discussion is currently ongoing with regard to the necessity for micro-electrode recording (MER) in DBS surgery.

The present review provides an overview on deep brain stimulation and (MER) of the STN in patients with Parkinson’s disease. Detailed description is given concerning the multichannel MER systems nowadays available for DBS of the basal ganglia, especially of the STN, as a useful tool for target refinement. Furthermore, an overview is given of the historical aspects, spatial mapping of the STN by MER, and its impact for accuracy and precision in current functional stereotactic neurosurgery.

The pros concerning target refinement by MER means on the one hand, and cons including increased bleeding risk, increased operation time, local or general anesthesia, and single versus multichannel microelectrode recording are discussed in detail. Finally, the authors favor the use of MER with intraoperative testing combined with imaging to achieve a more precise electrode placement, aiming to ameliorate clinical outcome in therapy-resistant movement disorders.


Deep brain stimulation Basal ganglia Microelectrode recording Movement disorders 


Conflict of Interest

Thomas M. Kinfe has received DBS training grant from Medtronic Inc. and training support from St. Jude Medical, Inc. Jan Vesper has been supported for travel and conference presentations from Medtronic Inc. and from St. Jude Medical, Inc.


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Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  1. 1.Center of Neuromodulation, Department of NeurosurgeryHeinrich-Heine University HospitalDüsseldorfGermany

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