Functional Neurosurgery in Parkinson’s Disease: A Long Journey from Destruction Over Modulation Towards Restoration

  • Guido NikkhahEmail author
  • Gustavo Adolpho Carvalho
  • Marcus Pinsker
Conference paper
Part of the Acta Neurochirurgica Supplement book series (NEUROCHIRURGICA, volume 117)


Neurosurgical treatment of Parkinson’s disease (PD) has re-gained considerable attention over the last two decades due to a better understanding of the pathophysiology of the basal ganglia, the long-term complications of medical treatment, and advances in neuroimaging and neurosurgical techniques. The introduction of deep brain stimulation (DBS) has created new perspectives for the surgical management of PD patients, due to the low morbidity, reversibility and improvement of both motor function and quality of life as compared to the lesioning techniques. We present an overview of basic principles, history, indications, and results of current neurosurgical techniques available in PD.


Parkinson’s disease Ablative techniques Deep brain stimulation 



Parts of this study have been supported by grants from the Weber Petri Foundation and the German Parkinson Foundation.

Conflict of Interest Drs. Pinsker and Nikkhah report having received speaking fees from Medtronic. Dr. Nikkhah has also served as a Consultant for Medtronic. No other potential conflict of interest relevant to this article was reported.


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Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Guido Nikkhah
    • 1
    • 2
    Email author
  • Gustavo Adolpho Carvalho
    • 3
  • Marcus Pinsker
    • 1
    • 4
  1. 1.Division of Stereotactic and Functional Neurosurgery, Department of General Neurosurgery, Neurosurgical ClinicUniversity Medical Center FreiburgFreiburgGermany
  2. 2.Neurosurgical ClinicUniversity Hospital ErlangenErlangenGermany
  3. 3.Department of NeurosurgeryHospital Adventista Silvestre, Rio de Janeiro BrazilBotafogo, Rio de JaneiroBrazil
  4. 4.Klinik für NeurochirurgieHELIOS Klinikum Berlin-BuchBerlinGermany

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