Interstitial Radiosurgery with Iodine-125 Seeds in the Treatment of Brain Metastases, Glial Tumours and Benign Intracranial Lesions
In a retrospective single-centre study, we analysed data of 1,378 patients (55 % male, 45 % female) who underwent interstitial radiotherapy with 1,596 implanted Iodine-125 seeds in the Department of Stereotactic and Functional Neurosurgery in Freiburg from January 1990 to December 2011. The medical prerequisites and physical parameters of the treatment with Iodine-125 seeds are given. The method used in Freiburg relying on temporary Iodine-125 seed implants is described in detail and analysed. The survival rates and the peri-operative risk are evaluated. We conclude that interstitial radiosurgery with Iodine-125 seeds is a safe and useful tool, offering a wide range of treatment options for benign and also malignant intracranial lesions, especially if they are small, deep-seated, in eloquent areas, or not suitable for micro-surgery.
KeywordsBrachytherapy Iridium-192 Iodine-125 Seeds Interstitial radiotherapy Stereotactic biopsy Glioma Low-grade glioma Brain tumours Metastases Hamartoma Child Adults Survival Adverse events
I want to thank my teacher Professor Dr. C. B. Ostertag for giving us deep insights in the significance, practice, and handling of iodine seeds. We thank Professor M. Schumacher and his distinguished team from the Department of Neuroradiology, University Medical Centre Freiburg for their cooperation, and for providing us with excellent MRI imaging. Vera Gumpp from the Tumorzentrum Ludwig Heilmeyer, Comprehensive Cancer Center Freiburg (CCCF), University Medical Centre Freiburg supplied us with precise and controlled survival data. We thank Ms. Manuela Fellmann for her excellent work in the preparation of the International Congress on the occasion of the 60th anniversary of Stereotactic Neurosurgery in Freiburg, and for the handling of our manuscripts for this supplement.
- 12.Ostertag CB (1993) Brachytherapy-interstitial implant radiosurgery. Acta Neurochir Suppl (Wien) 58:79–84Google Scholar
- 16.Ruge MI, Simon T, Suchorska B, Lehrke R, Hamisch C, Koerber F, Maarouf M, Treuer H, Berthold F, Sturm V, Voges J (2011) Stereotactic brachytherapy with iodine-125 seeds for the treatment of inoperable low-grade gliomas in children: long-term outcome. J Clin Oncol 29:4151–4159PubMedCrossRefGoogle Scholar
- 18.Schulze-Bonhage A, Quiske A, Homberg V, Trippel M, Wagner K, Frings L, Bast T, Huppertz HJ, Warnke C, Ostertag C (2004) Effect of interstitial stereotactic radiosurgery on behavior and subjective handicap of epilepsy in patients with gelastic epilepsy. Epilepsy Behav 5:94–101PubMedCrossRefGoogle Scholar