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Brain Edema XV pp 103–109Cite as

Edaravone Increases Regional Cerebral Blood Flow After Traumatic Brain Injury in Mice

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Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 118))

Abstract

Traumatic brain injury (TBI) is a major cause of preventable death and serious morbidity, with subsequent low cerebral blood flow (CBF) considered to be associated with poor prognosis. In the present study, we demonstrated the effect of the free radical scavenger edaravone on regional CBF (rCBF) after TBI. Male mice (C57/BL6) were subjected to TBI using a controlled cortical impactor device. Immediately after TBI, the animals were intravenously administered 3.0 mg/kg of edaravone or a vehicle saline solution. Two-dimensional rCBF images were acquired before and 24 h post-TBI, and were quantified in the ipsilateral and contralateral hemispheres (n = 5 animals per group). CBF in the vehicle-treated animals decreased broadly over the ipsilateral hemisphere, with the region of low rCBF spreading from the frontal cortex to the occipital lobe. The zone of lowest rCBF matched that of the contusion area. The mean rCBF at 24 h for a defined elliptical region between the bregma and lambda was 73.7 ± 5.8 %. In comparison, the reduction of rCBF in edaravone-treated animals was significantly attenuated (93.4 ± 5.7 %, p < 0.05). The edaravone-treated animals also exhibited higher rCBF in the contralateral hemisphere compared with that seen in ­vehicle-treated animals. It is suggested that edaravone reduces neuronal damage by scavenging reactive oxygen species (ROS) and by maintaining intact the autoregulation of the cerebral vasculature.

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Acknowledgments

The project was supported by a Grant-in-Aid for Young Scientists (Start-up) from the Japanese Ministry of Education, Culture, Sports, Science and Technology (KM). This work was also supported in part by a grant from the Research on Health Sciences focusing on Drug Innovation program funded by The Japan Health Sciences Foundation (SS).

Conflict of InterestWe declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-Ku, Tokyo, 142-8555, Japan

    Kazuyuki Miyamoto, Hirokazu Ohtaki, Tomomi Tsumuraya, Hiroyasu Nakano, Keisuke Kiriyama, Dandan Song & Seiji Shioda

  2. Department of Emergency and Critical Care Medicine, Showa University School of Medicine, Shinagawa-Ku, Tokyo, 142-8555, Japan

    Kazuyuki Miyamoto, Kenji Dohi & Tohru Aruga

Authors
  1. Kazuyuki Miyamoto
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  2. Hirokazu Ohtaki
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  4. Tomomi Tsumuraya
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  6. Keisuke Kiriyama
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  9. Seiji Shioda
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Correspondence to Seiji Shioda .

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Editors and Affiliations

  1. School of Medicine, Dept. Neurological Surgery, Nihon University, Oyaguchikami-machi 30-1, Tokyo, 173-8610, Japan

    Yoichi Katayama

  2. School of Medicine, Departments of Neurological Surgery and, Nihon University, 30-1 Oyaguchi Kamimachi, Itabashi-ku, Tokyo, 173-8610, Japan

    Takeshi Maeda

  3. , Department of Clinical Laboratory, Namegata District General Hospital, 98-8 Inouefujii, Namegata 98-8, Ibaraki, 311-3516, Japan

    Toshihiko Kuroiwa

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Miyamoto, K. et al. (2013). Edaravone Increases Regional Cerebral Blood Flow After Traumatic Brain Injury in Mice. In: Katayama, Y., Maeda, T., Kuroiwa, T. (eds) Brain Edema XV. Acta Neurochirurgica Supplement, vol 118. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1434-6_18

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  • DOI: https://doi.org/10.1007/978-3-7091-1434-6_18

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  • Online ISBN: 978-3-7091-1434-6

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