Abstract
The primary pathology associated with mild traumatic brain injury (TBI) is selective axonal injury, which may characterize the vast majority of blast-induced TBIs. Axonal injuries in cases of mild TBI have been considered to be the main factors responsible for the long-lasting memory or attentional impairment in affected subjects. Among these axonal injuries, recent attention has been focused on the cingulum bundle (CB). Furthermore, recent studies with diffusion tensor MR imaging have shown the presence of injuries of the CB in cases of mild TBI in humans. This study aimed to provide a better laboratory model of mild TBI.
Sprague–Dawley rats were subjected to mild TBI using laser-induced shock waves (LISW) (sham, 0.5 J/cm2, or 1.0 J/cm2; n = 4 per group). Bodian-stained brain sections 14 days after LISW at 0.5 J/cm2 or 1.0 J/cm2 showed a decrease in the CB axonal density compared with the sham group, whereas there were no differences in the axonal density of the corpus callosum.
The present study shows that this model is capable of reproducing the histological changes associated with mild TBI.
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Acknowledgments
This study was supported by a research grant from The General Insurance Association of Japan.
Conflict of InterestWe declare that we have no conflict of interest.
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Takeuchi, S. et al. (2013). A Better Mild Traumatic Brain Injury Model in the Rat. In: Katayama, Y., Maeda, T., Kuroiwa, T. (eds) Brain Edema XV. Acta Neurochirurgica Supplement, vol 118. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1434-6_17
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DOI: https://doi.org/10.1007/978-3-7091-1434-6_17
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