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Endothelial Transcriptional Networks in the Control of Angiogenesis: the ETS Factor

  • Anna M. RandiEmail author
Chapter

Abstract

Endothelial gene expression is controlled by a few families of transcription factors (TF) which form regulatory networks. Amongst the most important are the ETS factors, a large family of which at least 19 members are expressed in human endothelial cells at some point throughout development. Through interaction with other TF families and co-regulators, ETS factors control most aspects of endothelial biology, from early differentiation in the embryo to homeostasis, angiogenesis and inflammation in the adult. Several ETS family members have been shown to be essential for vascular development and angiogenesis and to regulate processes from cell migration to survival and growth. Amongst the list of ETS targets genes involved in angiogenic pathways are growth factor receptors for vascular endothelial growth factor and angiopoietins. ETS factors also control cell adhesion, matrix remodelling and cytoskeletal dynamics, processes essential for tissue homeostasis, which therefore influence the viability and stability of new vascular networks. Most ETS proteins have been shown to activate transcription; however, a few can also act as transcriptional repressors. Several ETS factors can control the same target genes, raising the question of possible redundancy in the system. Data from a variety of in vivo models are shedding new light on the different roles of ETS factors in vascular development, adult angiogenesis and endothelial homeostasis. In this review some general properties of ETS factors in the endothelium are discussed and then two of the best characterised ETS proteins in endothelial cells, Ets-1 and Erg, which exemplify the complex picture of distinct and overlapping targets and functions, are presented.

Keywords

ETS transcription factors Angiogenesis Endothelial homeostasis Ets-1 Erg 

Notes

Acknowledgements

The unpublished work mentioned in this chapter has been supported by grants from the British Heart Foundation. My thanks to Dr. Graeme Birdsey (Imperial College London, UK) for his invaluable contribution to my laboratory over many years, to Prof. Dorian Haskard (Imperial College London, UK) for his support and encouragement and to Prof. Justin Mason (Imperial College London, UK) for his continuous support and for critical reading of the manuscript.

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Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  1. 1.Vascular Sciences UnitNational Heart and Lung Institute (NHLI), Imperial College London, Hammersmith HospitalLondonUK

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