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The Vasohibin Family: Novel Regulators of Angiogenesis

  • Yasufumi SatoEmail author
Chapter

Abstract

A number of endogenous regulators of angiogenesis have been found in the body. We isolated vasohibin-1 (VASH1) as a negative feedback regulator of angiogenesis produced by endothelial cells, and then VASH2 as a homologue of VASH1. We further explored that VASH1 is expressed in endothelial cells to terminate angiogenesis, whereas VASH2 is expressed in non-endothelial cells in the sprouting front to promote angiogenesis. This chapter will focus on this vasohibin family members, novel regulators of angiogenesis.

Keywords

Vasohibin-1 Vasohibin-2 Angiogenesis inhibitors VEGF Cancer Tumor angiogenesis 

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Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  1. 1.Department of Vascular BiologyInstitute of Development, Aging and Cancer, Tohoku UniversitySendaiJapan

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