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Nrf2 Transcription Factor and Heme Oxygenase-1 as Modulators of Vascular Injury and Angiogenesis

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Angiogenesis and Vascularisation

Abstract

The cytoprotective actions of Nrf2 transcription factor against vascular injuries associated with oxidative stress and tissue ischemia are widely reported. Amongst Nrf2 target genes, heme oxygenase-1 (HO-1) is responsible for at least a part of such protective effects by playing strong antioxidant and anti-inflammatory roles in the vascular system. Nonetheless, the area of Nrf2/HO-1 functioning could be extended to the control of vessel growth. Although the angiogenic involvement of HO-1 in physiological states and under conditions of tissue damage is well demonstrated, a direct role of Nrf2 in the process of blood vessel formation is just coming to light. Nrf2 has been linked to known angiogenic signaling pathways, comprising not only HO-1, but also vascular endothelial growth factor and hypoxia-inducible factor-1, and suggested to act in normal vascular development as well as in the formation of blood vessels nourishing tumor. Strikingly, Nrf2 deficiency may promote oxidative stress-related inflammatory neovascularization accompanying damaged/ischemic tissue regeneration. Thus, further studies are definitely required for a thorough assessment of Nrf2 place in the processes of blood vessel formation.

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Acknowledgments

The Faculty of Biochemistry, Biophysics and Biotechnology of the Jagiellonian University is a beneficiary of the structural funds from the European Union and the Polish Ministry of Science and Higher Education (grants No: POIG.02.01.00-12 064/08, POIG 01.01.02-00-109/09, POIG.02.02.00-014/08, and 01.01.02-00-069/09).

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  1. Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland

    Urszula Florczyk, Alicja Józkowicz & Józef Dulak

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  1. Urszula Florczyk
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  2. Alicja Józkowicz
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  3. Józef Dulak
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Correspondence to Józef Dulak .

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  1. Department of Medical Biotechnology, Jagiellonian University, Kraków, Poland, Kraków, Poland

    Józef Dulak

  2. Department of Medical Biotechnology, Jagiellonian University, Krakow, Poland, Krakow, Poland

    Alicja Józkowicz

  3. Department of Medical Biotechnology, Jagiellonian University, Kraków, Poland

    Agnieszka Łoboda

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Florczyk, U., Józkowicz, A., Dulak, J. (2013). Nrf2 Transcription Factor and Heme Oxygenase-1 as Modulators of Vascular Injury and Angiogenesis. In: Dulak, J., Józkowicz, A., Łoboda, A. (eds) Angiogenesis and Vascularisation. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1428-5_10

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