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Aging of Intestinal Stem Cells in Drosophila Melanogaster

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Stem Cell Aging: Mechanisms, Consequences, Rejuvenation

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Abstract

Drosophila m. has a long history of major contributions to basic biology and biomedical research. Not surprisingly, the recent identification of several multipotent stem cell populations in the Drosophila fly digestive tract has generated an immense enthusiasm in the research community. This experimental model provides a unique opportunity to study adult somatic stem cells, using the power of fly genetics. Over the past few years, research in this field has focused on the characterization of the signaling pathways and mechanisms that control stem cell function and tissue repair in the intestine. Importantly, the rapid aging and short lifespan of Drosophila make this model ideal to investigate the impact of aging on stem cell populations and test the contribution of somatic stem cells to normal healthspan and lifespan. This chapter presents recent findings that elucidate the mechanisms causing age-related loss of tissue homeostasis in the fly intestine, as well as strategies of stem cell-specific genetic manipulation that significantly impact physiology in aging animals and can extend lifespan.

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Authors and Affiliations

  1. Department of Biomedical Genetics, University of Rochester Medical Center, 633 Elmwood Avenue, Rochester, NY, USA

    Benoît Biteau

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Correspondence to Benoît Biteau .

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Editors and Affiliations

  1. Dermatology and Allergic Diseases, Ulm University, Ulm, Germany

    Hartmut Geiger

  2. Department of Biology, University of Rochester, Rochester, New York, USA

    Heinrich Jasper

  3. Dermatology and Allergic Diseases, Ulm University, Ulm, Germany

    Maria Carolina Florian

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Biteau, B. (2015). Aging of Intestinal Stem Cells in Drosophila Melanogaster . In: Geiger, H., Jasper, H., Florian, M. (eds) Stem Cell Aging: Mechanisms, Consequences, Rejuvenation. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1232-8_5

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