Abstract
Carbohydrates are expressed on majority of mammalian cell surfaces. They are bound to glycoproteins, proteins, and glycolipids, or to different cellular constituents, e.g. proteoglycans that are part of the cell membrane in clustered and multiantennary structures. These oligosaccharides represent signal transductors between extra- and intracellular media. Glyco- and glycopeptide dendrimers are excellent tools, which can be used for studies of inter- and intracellular signaling and also for their modulation. The capability of dendrimers to modulate intracellular signaling is strongly associated with their biological and therapeutic applications. In this chapter, several examples, how dendrimeric structures can influence intracellular enzymes (e.g. kinases or GTPases) that represent crucial components of intracellular signaling are presented.
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Šebestík, J., Reiniš, M., Ježek, J. (2012). Dendrimers Regulating Intracellular Signaling Pathways. In: Biomedical Applications of Peptide-, Glyco- and Glycopeptide Dendrimers, and Analogous Dendrimeric Structures. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1206-9_21
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DOI: https://doi.org/10.1007/978-3-7091-1206-9_21
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Publisher Name: Springer, Vienna
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