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Role of Platelet-Derived Growth Factor in Cerebral Vasospasm After Subarachnoid Hemorrhage in Rats

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Cerebral Vasospasm: Neurovascular Events After Subarachnoid Hemorrhage

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 115))

Abstract

Background and purpose: The role of platelet-derived growth factor (PDGF) remains unknown in cerebral vasospasm after subarachnoid hemorrhage (SAH). In this study, we examined the effects of PDGF receptor (PDGFR) inactivation on cerebral vasospasm in the endovascular perforation model of SAH in rats.

Methods: Rats were assigned to sham, SAH plus vehicle, and SAH plus imatinib mesylate (imatinib) groups (n = 4 per group). Imatinib (50 mg/kg body weight), an inhibitor of the tyrosine kinases of PDGFR, or vehicle was administered intraperitoneally 30 min post-SAH. Vasospasm was evaluated in the left (perforation-sided) internal carotid artery by means of neurobehavioral tests, India ink angiography, and immunohistochemistry at 24 h after SAH.

Results: Imatinib significantly inhibited post-SAH PDGFR activation in the left internal carotid artery, in which vasospasm was significantly prevented. Animal’s neurobehavior also showed a tendency to improve by imatinib treatment.

Conclusions: PDGF may play an important role in the pathogenesis of vasospasm after SAH.

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Acknowledgments

This work was supported in part by a grant-in-aid for scientific research from Japan Society for the Promotion of Science (22591584) and Mie Society for the Promotion of Medical Research to Dr. Suzuki.

Conflicts of Interest Statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan

    Masato Shiba M.D., Hidenori Suzuki M.D., Ph.D., Masashi Fujimoto M.D., Satoshi Matsushima M.D., Ph.D. & Waro Taki M.D., Ph.D.

  2. Research Center for Matrix Biology, Mie University, Tsu, Japan

    Hidenori Suzuki M.D., Ph.D., Naoshi Shimojo Ph.D., Kyoko Imanaka-Yoshida M.D., Ph.D. & Toshimichi Yoshida M.D., Ph.D.

  3. Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Tsu, Japan

    Naoshi Shimojo Ph.D., Kyoko Imanaka-Yoshida M.D., Ph.D. & Toshimichi Yoshida M.D., Ph.D.

  4. Department of Neurosurgery, Suzuka Kaisei Hospital, Suzuka, Japan

    Kenji Kanamaru M.D., Ph.D.

Authors
  1. Masato Shiba M.D.
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  2. Hidenori Suzuki M.D., Ph.D.
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  3. Masashi Fujimoto M.D.
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  4. Naoshi Shimojo Ph.D.
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  5. Kyoko Imanaka-Yoshida M.D., Ph.D.
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  6. Toshimichi Yoshida M.D., Ph.D.
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  7. Kenji Kanamaru M.D., Ph.D.
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  8. Satoshi Matsushima M.D., Ph.D.
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  9. Waro Taki M.D., Ph.D.
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Corresponding author

Correspondence to Masato Shiba M.D. .

Editor information

Editors and Affiliations

  1. , Department of Neurosurgery, University of Cincinnati, Stetson, Suite 2200 260, Cincinnati, 45267-0515, Ohio, USA

    Mario Zuccarello

  2. College of Medicine, Department of Neurology, University of Cincinnati, Albert Sabin Way 231MSB room 1, Cincinnati, 46267-0536, Ohio, USA

    Joseph F. Clark

  3. College of Medicine, Dept. of Neurology and Neurosurgery, University of Cincinnati, Albert Sabin Way 231ML0517, Cincinnati, 45267-0517, Ohio, USA

    Gail Pyne-Geithman

  4. College of Medicine, Dept. of Neurosurgery, University of Cincinnati, Stetson St. Suite 260ML0515, Cincinnati, 45219, Ohio, USA

    Norberto Andaluz

  5. College of Medicine, Dept. of Neurosurgery, University of Cincinnati, Stetson, Suite 2200 260, Cincinnati, 45219, Ohio, USA

    Jed A. Hartings

  6. , Dept. of Emergency Medicine, University of Cincinnati, Albert Sabin Way 231ML0769, Cincinnati, 45267-0769, Ohio, USA

    Opeolu M. Adeoye

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Shiba, M. et al. (2013). Role of Platelet-Derived Growth Factor in Cerebral Vasospasm After Subarachnoid Hemorrhage in Rats. In: Zuccarello, M., Clark, J., Pyne-Geithman, G., Andaluz, N., Hartings, J., Adeoye, O. (eds) Cerebral Vasospasm: Neurovascular Events After Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement, vol 115. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1192-5_40

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  • DOI: https://doi.org/10.1007/978-3-7091-1192-5_40

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-1191-8

  • Online ISBN: 978-3-7091-1192-5

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