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Animal Lectins: Form, Function and Clinical Applications pp 265–289Cite as

Galectin-3: Forms, Functions, and Clinical Manifestations

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Abstract

Gal-3 (formerly known as CBP35, Mac2, L-29, L-34, IgEBP, and LBP) is widely spread among different types of cells and tissues, found intracellularly in nucleus and cytoplasm or secreted via non-classical pathway out of cell, thus being found on the cell surface or in the extracellular space. Through specific interactions with a variety of intra- and extracellular proteins Gal-3 affects numerous biological processes and seems to be involved in different physiological and pathophysiological conditions, such as development, immune reactions, and neoplastic transformation and metastasis. Most members of the galectin family including Gal-1 possess apoptotic activities, whereas Gal-3 possesses anti-apoptotic activity as well. Information on structural, biochemical and intriguing functional properties of Gal-3 have been reviewed extensively (Dumic et al. 2006).

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  1. Department of Biomedical Engineering, Rayat and Bahra Institute of Engineering and Biotechnology, Kharar (Mohali), Punjab, India

    Anita Gupta (Assistant Professor)

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Gupta, A. (2012). Galectin-3: Forms, Functions, and Clinical Manifestations. In: Animal Lectins: Form, Function and Clinical Applications. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1065-2_12

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