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Aluminium-dependent human diseases and chelating properties of aluminium chelators for biomedical applications

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Metal Ions in Neurological Systems

Abstract

The aim of this chapter is to give a general view on the current status of the role of aluminium in human health and disease. The main aspects of aluminium metabolism in humans are covered, summarizing the state of knowledge on the absorption, transport, tissue distribution, and excretion of aluminium, giving particular emphasis to the main metabolic pathways of this metal ion in the bones and in the brain. Some features concerning the solution chemistry of aluminium are considered, giving special care to the speciation of aluminium hydroxides in municipal water and in water for dialysis. The function of different chelators utilized in clinical practice in the therapy of aluminium-depending diseases is discussed, providing some insight on the chelators recently proposed. As a last point the crystal structures of selected Al(III) complexes are presented and thoroughly discussed.

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Authors and Affiliations

  1. Dipartimento di Scienze Chimiche, Università di Cagliari, Monserrato, Italy

    Valeria Marina Nurchi

  2. Dipartimento di Scienze Chimiche, Università di Cagliari, Cittadella Universitaria, 09042, Monserrato, Italy

    Guido Crisponi

  3. Dipartimento di Chimica, Università di Ferrara, Ferrara, Italy

    Valerio Bertolasi & Maurizio Remelli

  4. Centro di Strutturistica Diffrattometrica, Università di Ferrara, Ferrara, Italy

    Valerio Bertolasi

  5. Dipartimento di Citomorfologia, Divisione di Anatomia Patologica, Università di Cagliari, Cagliari, Italy

    Gavino Faa

Authors
  1. Valeria Marina Nurchi
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  2. Guido Crisponi
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  3. Valerio Bertolasi
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  4. Gavino Faa
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  5. Maurizio Remelli
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Correspondence to Guido Crisponi .

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  1. , Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, Vienna, 1060, Austria

    Wolfgang Linert

  2. Faculty of Chemistry, University of Wroclaw, ul. Fryderyka Joliot Curie 14, Wroclaw, 50-383, Poland

    Henryk Kozlowski

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Nurchi, V.M., Crisponi, G., Bertolasi, V., Faa, G., Remelli, M. (2012). Aluminium-dependent human diseases and chelating properties of aluminium chelators for biomedical applications. In: Linert, W., Kozlowski, H. (eds) Metal Ions in Neurological Systems. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1001-0_10

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