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Store-operated Ca2+ entry (SOCE) pathways pp 177–192Cite as

The Role of Mitochondria in the Activation/Maintenance of SOCE

Store-operated Ca2+ Entry and Mitochondria

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Abstract

Mitochondria modify cellular Ca2+ transport processes and, in turn, almost every Ca2+ signaling event has a notable effect on mitochondrial function. This kind of reciprocal interplay between Ca2+ handling and mitochondria is especially prominent during store-operated Ca2+ entry (SOCE). Localization of mitochondria, Ca2+ uptake and efflux into and out of the organelle, and even release of metabolites from the mitochondria have been shown to substantially modify SOCE. On the other hand, Ca2+ entering the cell through store-operated channels is sequestered by mitochondria. The ensuing mitochondrial Ca2+ signal activates the reduction of pyridine nucleotides and promotes ATP synthesis and thereby adjusts energy metabolism to cellular demands. Mitochondrial Ca2+ accumulation also supports cell specific functions such as steroid and insulin secretion. Early observations have suggested that mitochondria need to be localized in the vicinity of store-operated channels for efficient SOCE to occur. Recent studies in numerous cell types, however, have shown that mitochondria are not located in the molecular proximity of store-operated channels but Ca2+diffuses to mitochondria from the nearby orifice of the channels. Consequently, the formation of high Ca2+ perimitochondrial microdomains is not a sine qua non for SOCE-mitochondrion cooperation.

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Authors and Affiliations

  1. Department of Physiology, Semmelweis University, Hungarian Academy of Sciences, Budapest, Hungary

    András Spät & Gergö Szanda

  2. Laboratory of Neurobiochemistry and Molecular Physiology, Hungarian Academy of Sciences, Budapest, Hungary

    András Spät

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  1. András Spät
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  2. Gergö Szanda
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Correspondence to András Spät .

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  1. Center for Physiological Medicine, Medical University of Graz, Harrachgasse 21/IV, Graz, 8010, Austria

    Klaus Groschner

  2. , Center for Molecular Medicine, Medical University of Graz, Harrachgasse 21/III, Graz, 8010, Austria

    Wolfgang F. Graier

  3. , Institute of Biophysics, University of Linz, Gruberstrasse 40, Linz, 4020, Austria

    Christoph Romanin

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Spät, A., Szanda, G. (2012). The Role of Mitochondria in the Activation/Maintenance of SOCE. In: Groschner, K., Graier, W., Romanin, C. (eds) Store-operated Ca2+ entry (SOCE) pathways. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0962-5_13

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