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The Effect of Body Position on Intraocular and CSF Pressures in the Lateral Ventricle, and in Cortical and Lumbar Subarachnoid Spaces in Cats

Part of the Acta Neurochirurgica Supplementum book series (NEUROCHIRURGICA,volume 114)


Background: Correlation between cerebrospinal fluid (CSF) and intraocular pressure (IOP) is still unclear. We compared CSF pressure from different parts of the CSF system and IOP measured by the same invasive technique in a new experimental model in cats during changes of body position.

Methods: Pressure changes were recorded on anesthetized cats (n = 7) in the lateral ventricle (LV), in the cortical (CSS) and lumbar (LSS) subarachnoid spaces, and in the anterior ocular chamber. Animals and measuring instruments were both fixed on a board at an adequate hydrostatic level.

Results: In a horizontal position, IOP (18.5 ± 0.6 cm H2O) and CSF pressures (LV = 17.4 ± 0.9; CSS = 17.2 ± 0.7; LSS = 17.8 ± 1.2 cm H2O) were similar. In a vertical position, pressure in the LSS increased (33.5 ± 2.3 cm H2O), pressures inside the cranial cavity dropped (LV = −4.1 ± 0.9 cm H2O; CSS = −4.8 ± 0.5 cm H2O), while IOP slightly decreased (14.3 ± 0.1 cm H2O).

Conclusion: Change in body position from horizontal to upright causes drastic changes in CSF pressure and relatively small changes in IOP, which indicates that the IOP does not reflect CSF pressure. In an upright position, CSF pressures were equal at the same hydrostatic level in LV and CSS, which suggests that CSF pressure inside the cranium depends on its anatomical and biophysical features, and not on CSF secretion and absorption.


  • Body position
  • Intraocular pressure
  • Cerebrospinal fluid pressure
  • Cerebrospinal fluid hydrodynamics

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We thank Mrs. Ljiljana Krznar for her skilled technical assistance. This work has been supported by the Ministry of Science, Education, and Sport of the Republic of Croatia (Projects: 1. Hydrodynamics of cerebrospinal fluid. No. 098-1080231-2328; and 2. Pathophysiology of cerebrospinal fluid and intracranial pressure. No. 108-1080231-0023).

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Correspondence to Marijan Klarica .

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Kuzman, T. et al. (2012). The Effect of Body Position on Intraocular and CSF Pressures in the Lateral Ventricle, and in Cortical and Lumbar Subarachnoid Spaces in Cats. In: Schuhmann, M., Czosnyka, M. (eds) Intracranial Pressure and Brain Monitoring XIV. Acta Neurochirurgica Supplementum, vol 114. Springer, Vienna.

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