Skip to main content

The Effect of Body Position on Intraocular and CSF Pressures in the Lateral Ventricle, and in Cortical and Lumbar Subarachnoid Spaces in Cats

Part of the Acta Neurochirurgica Supplementum book series (NEUROCHIRURGICA,volume 114)

Abstract

Background: Correlation between cerebrospinal fluid (CSF) and intraocular pressure (IOP) is still unclear. We compared CSF pressure from different parts of the CSF system and IOP measured by the same invasive technique in a new experimental model in cats during changes of body position.

Methods: Pressure changes were recorded on anesthetized cats (n = 7) in the lateral ventricle (LV), in the cortical (CSS) and lumbar (LSS) subarachnoid spaces, and in the anterior ocular chamber. Animals and measuring instruments were both fixed on a board at an adequate hydrostatic level.

Results: In a horizontal position, IOP (18.5 ± 0.6 cm H2O) and CSF pressures (LV = 17.4 ± 0.9; CSS = 17.2 ± 0.7; LSS = 17.8 ± 1.2 cm H2O) were similar. In a vertical position, pressure in the LSS increased (33.5 ± 2.3 cm H2O), pressures inside the cranial cavity dropped (LV = −4.1 ± 0.9 cm H2O; CSS = −4.8 ± 0.5 cm H2O), while IOP slightly decreased (14.3 ± 0.1 cm H2O).

Conclusion: Change in body position from horizontal to upright causes drastic changes in CSF pressure and relatively small changes in IOP, which indicates that the IOP does not reflect CSF pressure. In an upright position, CSF pressures were equal at the same hydrostatic level in LV and CSS, which suggests that CSF pressure inside the cranium depends on its anatomical and biophysical features, and not on CSF secretion and absorption.

Keywords

  • Body position
  • Intraocular pressure
  • Cerebrospinal fluid pressure
  • Cerebrospinal fluid hydrodynamics

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-7091-0956-4_69
  • Chapter length: 5 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   269.00
Price excludes VAT (USA)
  • ISBN: 978-3-7091-0956-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   349.99
Price excludes VAT (USA)
Hardcover Book
USD   349.99
Price excludes VAT (USA)
Fig. 1
Fig. 2

References

  1. Aihara M, Lindsey JD, Weinreb RN (2003) Episcleral venous pressure of mouse eyes and effect of body position. Curr Eye Res 27:355–362

    PubMed  CrossRef  Google Scholar 

  2. Alperin N, Hushek SG, Lee SH, Sivaramakrishman A, Lichtor T (2005) MRI study of cerebral blood flow and CSF flow dynamics in an upright posture: the effect of posture on intracranial compliance and pressure. Acta Neurochir (Wien) 95:177–181

    CrossRef  CAS  Google Scholar 

  3. Bulat M, Klarica M (2010) Recent insight into a new hydrodynamics of cerebrospinal fluid. Brain Res Rev. doi: 10.1016/j.brainresrev.2010.08.002

  4. Czarnik T, Gawda R, Kolodziej W, Latka D, Sznajd-Weron K, Weron R (2009) Associations between intracranial pressure, intraocular pressure and mean arterial pressure in patients with traumatic and non-traumatic brain injuries. Injury 40:33–39

    PubMed  CrossRef  Google Scholar 

  5. Klarica M, Radoš M, Draganić P, Erceg G, Orešković D, Maraković J, Bulat M (2006) Effect of head position on cerebrospinal fluid pressure in cats: comparison with artificial model. Croat Med J 47:233–238

    PubMed  Google Scholar 

  6. Komaromy AM, Garg CD, Ying GS, Liu C (2006) Effect of head position on intraocular pressure in horses. Am J Vet Res 67:1232–1235

    PubMed  CrossRef  Google Scholar 

  7. Landau LD, Lifshitz EM (2005) Fluid mechanics. In: Course of theoretical physics, vol 6, 2nd English edn. Revised. Elsevier, Amsterdam, pp 5–7

    Google Scholar 

  8. Lashutka M, Chandra A, Murray H, Phillips G, Hiestand B (2005) The relationship of intraocular pressure to intracranial pressure. Ann Emerg Med 45:585–591

    Google Scholar 

  9. Longo A, Geiser MH, Riva C (2004) Posture changes and subfoveal choroidal blood flow. Invest Ophthalmol Vis Sci 45:546–551

    PubMed  CrossRef  Google Scholar 

  10. Macri FJ, Dixon R, Rall DP (1965) Aqueous humor turnover rates in the cat. I. Effect of acetazolamide. Invest Ophthalmol 4:927–934

    PubMed  CAS  Google Scholar 

  11. Magnaes B (1978) Movement of cerebrospinal fluid within the craniospinal space when sitting up and lying down. Surg Neurol 10:45–49

    PubMed  CAS  Google Scholar 

  12. Orešković D, Klarica M (2010) The formation of cerebrospinal fluid: nearly a hundred years of interpretations and misinterpretations. Brain Res Rev 64:241–262

    PubMed  CrossRef  Google Scholar 

  13. Salman MS (1997) Can intracranial pressure be measured non-invasively? Lancet 350:1367

    PubMed  CrossRef  CAS  Google Scholar 

  14. Sheeran P, Bland JM, Hall GM (2000) Intraocular pressure changes and alterations in intracranial pressure (letter). Lancet 355:899

    PubMed  CrossRef  CAS  Google Scholar 

  15. Snider RS, Niemer WT (1964) A stereotaxic atlas of the cat brain, 2nd edn. Meriden Gravure Company, Chicago

    Google Scholar 

  16. Wang YL, Toris CB, Zhan G, Yablonski ME (1999) Effects of topical epinephrine on aqueous humor dynamics in the cat. Exp Eye Res 68:439–445

    PubMed  CrossRef  CAS  Google Scholar 

Download references

Acknowledgements

We thank Mrs. Ljiljana Krznar for her skilled technical assistance. This work has been supported by the Ministry of Science, Education, and Sport of the Republic of Croatia (Projects: 1. Hydrodynamics of cerebrospinal fluid. No. 098-1080231-2328; and 2. Pathophysiology of cerebrospinal fluid and intracranial pressure. No. 108-1080231-0023).

Conflict of interest statement

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marijan Klarica .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 2012 Springer-Verlag/Wien

About this chapter

Cite this chapter

Kuzman, T. et al. (2012). The Effect of Body Position on Intraocular and CSF Pressures in the Lateral Ventricle, and in Cortical and Lumbar Subarachnoid Spaces in Cats. In: Schuhmann, M., Czosnyka, M. (eds) Intracranial Pressure and Brain Monitoring XIV. Acta Neurochirurgica Supplementum, vol 114. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0956-4_69

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-0956-4_69

  • Published:

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-0955-7

  • Online ISBN: 978-3-7091-0956-4

  • eBook Packages: MedicineMedicine (R0)