Abstract
Introduction: Multivariate data analyses have the potential to enrich the use of the complex plethora of data gathered in the care of critically ill patients. We sought to apply hierarchical cluster analysis to investigate factors affecting outcome in children with acute brain injury requiring ICP monitoring.
Methods: We performed a retrospective analysis on patients admitted to the pediatric intensive care unit with ICP monitoring for management of acute brain injury between 2003 and 2008. We performed cluster analysis comparing survivors and non-survivors. We compared the area the under the curve (time and duration above a determined value) between groups.
Results: We identified 32 patients among whom 8 died during hospitalization. Cluster analysis identified an association among CPP, PaCO2, and end-tidal CO2, and among ICP, central venous pressure, and lactate, in addition to other unexpected associations. Values (mean ± SD) for ICP in survivors (13.7 ± 7.9 mmHg) were lower than (42.7 ± 36.2) in non-survivors. Mean (59.4 vs 41.3), and minimum (47.3 vs 28.1) CPP were higher in survivors. The AUC for ICP was greater in the subjects who died and cluster analyses supported the importance of ICP and CPP related to outcome.
Conclusions: The dose of abnormal ICP may contribute to outcome in insults that involve increased ICP. These results are proof of principle of the potential application of hierarchical clustering to the clinical practice of pediatric neurocritical care.
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Adelson P, Bratton S, Carney N, Chesnut R, du Coudray H, Goldstein B, Kochanek P, Miller H, Partington M, Selden N, Warden C, Wright D (2003) Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 8. Cerebral perfusion pressure. Pediatr Crit Care Med 4:S31–S33
Adelson P, Bratton S, Carney N, Chesnut R, du Coudray H, Goldstein B, Kochanek P, Miller H, Partington M, Selden N, Warden C, Wright D (2003) Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 6. Threshold for treatment of intracranial hypertension. Pediatr Crit Care Med 4:S25–S27
Adelson P, Ragheb J, Muizelaar J, Kanev P, Brockmeyer D, Beers S, Brown S, Cassidy L, Chang Y, Levin H (2005) Phase II clinical trial of moderate hypothermia after severe traumatic brain injury in children. Neurosurgery 56:740–754
Chambers I, Jones P, Lo T, Forsyth R, Fulton B, Andrews P, Mendelow A, Minns R (2006) Critical thresholds of intracranial pressure and cerebral perfusion pressure related to age in paediatric head injury. J Neurol Neurosurg Psychiatry 77:234–240
Chambers I, Stobbart L, Jones P, Kirkham F, Marsh M, Mendelow A, Minns R, Struthers S, Tasker R (2005) Age-related differences in intracranial pressure and cerebral perfusion pressure in the first 6 hours of monitoring after children’s head injury: association with outcome. Childs Nerv Syst 21:195–199
Cohen M, Grossman A, Morabito D, Knudson M, Butte A, Manley G (2010) Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis. Crit Care 14:R10
Sorani M, Hemphill J, Morabito D, Rosenthal G, Manley G (2007) New approaches to physiological informatics in neurocritical care. Neurocrit Care 6:1–8
Webb C, Pass H (2004) Translational research: from accurate diagnosis to appropriate treatment. J Transl Med 2:35
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Dr. Wainwright serves as a scientific consultant to TransMed Systems.
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Wainwright, M.S., Lewandowski, R. (2012). Bioinformatics Analysis of Mortality Associated with Elevated Intracranial Pressure in Children. In: Schuhmann, M., Czosnyka, M. (eds) Intracranial Pressure and Brain Monitoring XIV. Acta Neurochirurgica Supplementum, vol 114. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0956-4_12
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