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Hydrocephalus and Aquaporins: The Role of Aquaporin-4

Conference paper
First Online:
Part of the Acta Neurochirurgica Supplementum book series (NEUROCHIRURGICA, volume 113)

Abstract

Introduction: Aquaporins (AQPs) are membrane proteins that facilitate water and small solute movement in tissues. Hydrocephalus is the major central nervous system disorder associated with defective cerebrospinal fluid turnover. Aquaporin-4 (AQP4) is a water channel located mainly at the blood–brain barrier (BBB) and blood–cerebrospinal fluid (CSF) interfaces and is associated with the elimination of cerebral edema via these routes. The aim of this study is to review the pertinent literature concerning the role of AQP4 in the pathophysiology of hydrocephalus.

Methods: We performed a MEDLINE search using the terms aquaporin AND hydrocephalus. The results of the search were further refined to exclude studies not related to aquaporin-4.

Results: Six studies were identified. All studies utilized an animal model such as AQP4-knockout mice, H-Tx rats, and kaolin and L-α-lysophosphatidylcholine (LPC) stearoyl injection models of hydrocephalus. Most studies indicate that there is an up-regulation of AQP4 expression at the BBB and blood–CSF interfaces in cases of hydrocephalus. One study, reported sporadic cases of obstructive hydrocephalus in a subgroup of AQP4-knockout mice.

Conclusions: Few publications have studied the association between aquaporins and hydrocephalus. Currently, all the existing studies rely on animal models. An adaptive and protective role of AQP4 to increase the resolution of the “hydrocephalic” edema at the BBB and blood–CSF interfaces is proposed in the pathophysiology of hydrocephalus. Further research is needed to clarify if this association exists in humans.

Keywords

Aquaporin AQP4 Cerebrospinal fluid (CSF) Hydrocephalus Water channel 
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Notes

Conflicts of interest statement

We declare that we have no conflict of interest.

References

  1. 1.
    Agre P, King LS, Yasui M, Guggino WB, Ottersen OP, Fujiyoshi Y, Engel A, Nielsen S (2002) Aquaporin water channels–from atomic structure to clinical medicine. J Physiol 542:3–16PubMedCrossRefGoogle Scholar
  2. 2.
    Agre P, Kozono D (2003) Aquaporin water channels: molecular mechanisms for human diseases. FEBS Lett 555:72–78PubMedCrossRefGoogle Scholar
  3. 3.
    Badaut J, Brunet JF, Grollimund L, Hamou MF, Magistretti PJ, Villemure JG, Regli L (2003) Aquaporin 1 and aquaporin 4 expression in human brain after subarachnoid hemorrhage and in peritumoral tissue. Acta Neurochir Suppl 86:495–498PubMedCrossRefGoogle Scholar
  4. 4.
    Badaut J, Lasbennes F, Magistretti PJ, Regli L (2002) Aquaporins in brain: distribution, physiology, and pathophysiology. J Cereb Blood Flow Metab 22:367–378PubMedCrossRefGoogle Scholar
  5. 5.
    Bloch O, Auguste KI, Manley GT, Verkman AS (2006) Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice. J Cereb Blood Flow Metab 26:1527–1537PubMedCrossRefGoogle Scholar
  6. 6.
    Cserr HF (1971) Physiology of the choroid plexus. Physiol Rev 51:273–311PubMedGoogle Scholar
  7. 7.
    Feng X, Papadopoulos MC, Liu J, Li L, Zhang D, Zhang H, Verkman AS, Ma T (2009) Sporadic obstructive hydrocephalus in Aqp4 null mice. J Neurosci Res 87:1150–1155PubMedCrossRefGoogle Scholar
  8. 8.
    Hirt L, Ternon B, Price M, Mastour N, Brunet J-F, Badaut J (2009) Protective role of early aquaporin 4 induction against postischemic edema formation. J Cereb Blood Flow Metab 29:423–433PubMedCrossRefGoogle Scholar
  9. 9.
    Kimelberg HK (2004) Water homeostasis in the brain: basic concepts. Neuroscience 129:851–860PubMedCrossRefGoogle Scholar
  10. 10.
    Klatzo I (1994) Evolution of brain edema concepts. Acta Neurochir Suppl 60:3–6Google Scholar
  11. 11.
    Macaulay N, Zeuthen T (2010) Water transport between CNS compartments: contributions of aquaporins and cotransporters. Neuroscience 168:941–956PubMedCrossRefGoogle Scholar
  12. 12.
    Manley GT, Binder DK, Papadopoulos MC, Verkman AS (2004) New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice. Neuroscience 129:983–991PubMedCrossRefGoogle Scholar
  13. 13.
    Mao X, Enno TL, Del Bigio MR (2006) Aquaporin 4 changes in rat brain with severe hydrocephalus. Eur J Neurosci 23:2929–2936PubMedCrossRefGoogle Scholar
  14. 14.
    Marmarou A (2007) A review of progress in understanding the pathophysiology and treatment of brain edema. Neurosurg Focus 22:E1Google Scholar
  15. 15.
    Mcallister JP, Miller JM (2006) Aquaporin 4 and hydrocephalus. J Neurosurg 105:457–458; discussion 458PubMedGoogle Scholar
  16. 16.
    Mobasheri A, Marples D (2004) Expression of the AQP-1 water channel in normal human tissues: a semiquantitative study using tissue microarray technology. Am J Physiol Cell Physiol 286:C529–C537PubMedCrossRefGoogle Scholar
  17. 17.
    Nico B, Mangieri D, Tamma R, Longo V, Annese T, Crivellato E, Pollo B, Maderna E, Ribatti D, Salmaggi A (2009) Aquaporin-4 contributes to the resolution of peritumoural brain oedema in human glioblastoma multiforme after combined chemotherapy and radiotherapy. Eur J Cancer 45:3315–3325PubMedCrossRefGoogle Scholar
  18. 18.
    Papadopoulos MC, Manley GT, Krishna S, Verkman AS (2004) Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J 18:1291–1293PubMedGoogle Scholar
  19. 19.
    Papadopoulos MC, Saadoun S, Binder DK, Manley GT, Krishna S, Verkman AS (2004) Molecular mechanisms of brain tumor edema. Neuroscience 129:1011–1020PubMedCrossRefGoogle Scholar
  20. 20.
    Papadopoulos MC, Verkman AS (2007) Aquaporin-4 and brain edema. Pediatr Nephrol 22:778–784PubMedCrossRefGoogle Scholar
  21. 21.
    Paul L, Madan M, Rammling M, Behman B, Pattisapu JV (2009) The altered expression of aquaporin 1 and 4 in choroid plexus of congenital hydrocephalus. Cerebrospinal Fluid Res 6:S7CrossRefGoogle Scholar
  22. 22.
    Praetorius J, Nielsen S (2006) Distribution of sodium transporters and aquaporin-1 in the human choroid plexus. Am J Physiol Cell Physiol 291:C59–C67PubMedCrossRefGoogle Scholar
  23. 23.
    Saadoun S, Papadopoulos M, Bell B, Krishna S, Davies D (2002) The aquaporin-4 water channel and brain tumour oedema. J Anat 200:528CrossRefGoogle Scholar
  24. 24.
    Shen XQ, Miyajima M, Ogino I, Arai H (2006) Expression of the water-channel protein aquaporin 4 in the H-Tx rat: possible compensatory role in spontaneously arrested hydrocephalus. J Neurosurg 105:459–464PubMedGoogle Scholar
  25. 25.
    Tait MJ, Saadoun S, Bell BA, Papadopoulos MC (2008) Water movements in the brain: role of aquaporins. Trends Neurosci 31:37–43PubMedCrossRefGoogle Scholar
  26. 26.
    Tait MJ, Saadoun S, Bell BA, Verkman AS, Papadopoulos MC (2010) Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage. Neuroscience 167:60–67PubMedCrossRefGoogle Scholar
  27. 27.
    Tourdias T, Dragonu I, Fushimi Y, Deloire MSA, Boiziau C, Brochet B, Moonen C, Petry KG, Dousset V (2009) Aquaporin 4 correlates with apparent diffusion coefficient and hydrocephalus severity in the rat brain: a combined MRI-histological study. Neuroimage 47:659–666PubMedCrossRefGoogle Scholar
  28. 28.
    Verkman AS (2009) Aquaporins: translating bench research to human disease. J Exp Biol 212:1707–1715PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 2012

Authors and Affiliations

  1. 1.Division of Neurological Surgery, Barrow Neurological InstituteSt. Joseph’s Hospital and Medical CenterPhoenixUSA
  2. 2.The Chiari Institute, HofstraNorthshore LIJ College of MedicineGreat NeckUSA

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