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Carbohydrate Mimetic Peptide Vaccines

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Anticarbohydrate Antibodies

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Abstract

Post-translational modifications of lipids and proteins are important determinants in defining function in both normal- and disease-state biology (Apweiler et al. 1999; Bertozzi and Kiessling 2001; Shental-Bechor and Levy 2009; Varki 1993). In particular, the addition of glycan residues synthesized by the repertoire of glycosyltransferases and glycosidases provide the mammalian glycome a large array of glycan structures that add to the diversity already created by the proteome (Cattaruzza and Perris 2006). At the same time, many glycan structures are ubiquitous in nature (van Die and Cummings 2009). Pathogen glycans can mimic host mammalian glycosphingolipids, lending to their pathophysiology. This mimicry provides insight into the processes contributing to their pathophysiology, including elements of recognition, signaling, and evasion of the immune system by glycan processing (Tsai 2001).

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Authors and Affiliations

  1. Department of Pathology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences Little Rock, Little Rock, AR, USA

    Somdutta Saha, Anastas Pashov, Behjatolah Monzavi-Karbassi, Ann Marie Kieber-Emmons & Thomas Kieber-Emmons

  2. Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA, USA

    Akashi Otaki & Ramachandran Murali

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  1. Somdutta Saha
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  2. Anastas Pashov
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Correspondence to Thomas Kieber-Emmons .

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  1. , Department für Chemie, Universität für Bodenkultur Wien, Muthgasse 18, Wien, 1190, Austria

    Paul Kosma

  2. , Zentrum für Medizin und Biowissenschafte, Forschungszentrum Borstel, Parkallee 22, Borstel, 23845, Germany

    Sven Müller-Loennies

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Saha, S. et al. (2012). Carbohydrate Mimetic Peptide Vaccines. In: Kosma, P., Müller-Loennies, S. (eds) Anticarbohydrate Antibodies. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0870-3_10

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