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Functional MRI

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Brain Mapping

Abstract

Since blood oxygenation level dependent (BOLD) signal changes have been observed using MRI [45] and modulated using neuronal stimuli [4, 46], functional MRI (fMRI) has quickly become the most popular functional neuroimaging technique in clinical practice and cognitive neuroscience. Indeed, high-field MR scanners and BOLD sensitive sequences are now widely accessible in both clinical and research settings. Moreover, fMRI is non-invasive. BOLD signal that relies on deoxyhemoglin (deoxyHb) concentration is detectable without injection of external contrast media. The colorful activation maps combined with three-dimensional brain anatomy may have also made this imaging method as much attractive as controversial [44, 56].

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References

  1. Altamura C, Reinhard M, Vry MS, Kaller CP, Hamzei F, Vernieri F, Rossini PM, Hetzel A, Weiller C, Saur D (2009) The longitudinal changes of BOLD response and cerebral hemodynamics from acute to subacute stroke. A fMRI and TCD study. BMC Neurosci 10: 151

    Article  Google Scholar 

  2. Bandettini PA, Jesmanowicz A, Wong EC, Hyde JS (1993) Processing strategies for time-course data sets in functional MRI of the human brain. Magn Reson Med 30: 161–173

    Article  PubMed  CAS  Google Scholar 

  3. Bartos R, Jech R, Vymazal J, Petrovicky P, Vachata P, Hejcl A, Zolal A, Sames M (2009) Validity of primary motor area localization with fMRI versus electric cortical stimulation: a comparative study. Acta Neurochir (Wien) 151: 1071–1080

    Article  Google Scholar 

  4. Belliveau JW, Kwong KK, Kennedy DN, Baker JR, Stern CE, Benson R, Chesler DA, Weisskoff RM, Cohen MS, Tootell RB et al (1992) Magnetic resonance imaging mapping of brain function. Human visual cortex. Invest Radiol 27(Suppl) 2: S59–65

    Article  Google Scholar 

  5. Boxerman JL, Bandettini PA, Kwong KK, Baker JR, Davis TL, Rosen BR, Weisskoff RM (1995) The intravascular contribution to fMRI signal change: Monte Carlo modeling and diffusion-weighted studies in vivo. Magn Reson Med 34: 4–10

    Article  PubMed  CAS  Google Scholar 

  6. Brown GG, Eyler Zorrilla LT, Georgy B, Kindermann SS, Wong EC, Buxton RB (2003) BOLD and perfusion response to finger-thumb apposition after acetazolamide administration: differential relationship to global perfusion. J Cereb Blood Flow Metab 23: 829–837

    Article  PubMed  CAS  Google Scholar 

  7. Brown GG, Perthen JE, Liu TT, Buxton RB (2007) A primer on functional magnetic resonance imaging. Neuropsychol Rev 17: 107–125

    Article  PubMed  Google Scholar 

  8. Buxton RB (2009) Introduction to functional magnetic resonance imaging. 2nd edn. Cambridge University Press, Cambridge

    Book  Google Scholar 

  9. Chen CM, Hou BL, Holodny AI (2008) Effect of age and tumor grade on BOLD functional MR imaging in preoperative assessment of patients with glioma. Radiology 248: 971–978

    Article  PubMed  Google Scholar 

  10. Chiarelli PA, Bulte DP, Wise R, Gallichan D, Jezzard P (2007) A calibration method for quantitative BOLD fMRI based on hyperoxia. Neuroimage 37: 808–820

    Article  PubMed  Google Scholar 

  11. D‘Esposito M, Deouell LY, Gazzaley A (2003) Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging. Nat Rev Neurosci 4: 863–872

    Article  PubMed  Google Scholar 

  12. Davis TL, Kwong KK, Weisskoff RM, Rosen BR (1998) Calibrated functional MRI: mapping the dynamics of oxidative metabolism. Proc Natl Acad Sci USA 95: 1834–1839

    Article  PubMed  CAS  Google Scholar 

  13. Devor A, Dunn AK, Andermann ML, Ulbert I, Boas DA, Dale AM (2003) Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex. Neuron 39: 353–359

    Article  PubMed  CAS  Google Scholar 

  14. Duffau H, Lopes M, Arthuis F, Bitar A, Sichez JP, Van Effenterre R, Capelle L (2005) Contribution of intraoperative electrical stimulations in surgery of low grade gliomas: a comparative study between two series without (1985–96) and with (1996–2003) functional mapping in the same institution. J Neurol Neurosurg Psychiatry 76: 845–851

    Article  PubMed  CAS  Google Scholar 

  15. Fox MD, Raichle ME (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8: 700–711

    Article  PubMed  CAS  Google Scholar 

  16. Fujiwara N, Sakatani K, Katayama Y, Murata Y, Hoshino T, Fukaya C, Yamamoto T (2004) Evoked-cerebral blood oxygenation changes in false-negative activations in BOLD contrast functional MRI of patients with brain tumors. Neuroimage 21: 1464–1471

    Article  PubMed  Google Scholar 

  17. Gasser T, Sandalcioglu E, Schoch B, Gizewski E, Forsting M, Stolke D, Wiedemayer H (2005) Functional magnetic resonance imaging in anesthetized patients: a relevant step toward real-time intraoperative functional neuroimaging. Neurosurgery 57: 94–99; discussion 94–99

    Article  PubMed  Google Scholar 

  18. Girouard H, Iadecola C (2006) Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. J Appl Physiol 100: 328–335

    Article  PubMed  CAS  Google Scholar 

  19. Gotman J (2008) Epileptic networks studied with EEGfMRI. Epilepsia 49(Suppl) 3: 42–51

    Article  PubMed  Google Scholar 

  20. Grouiller F, Vercueil L, Krainik A, Segebarth C, Kahane P, David O (2010) Characterization of the hemodynamic modes associated with interictal epileptic activity using a deformable model-based analysis of combined EEG and functional MRI recordings. Hum Brain Mapp (in press)

    Google Scholar 

  21. Hajnal JV, Myers R, Oatridge A, Schwieso JE, Young IR, Bydder GM (1994) Artifacts due to stimulus correlated motion in functional imaging of the brain. Magn Reson Med 31: 283–291

    Article  PubMed  CAS  Google Scholar 

  22. Haller S, Bartsch AJ (2009) Pitfalls in FMRI. Eur Radiol 19: 2689–2706

    Article  PubMed  Google Scholar 

  23. Hamzei F, Knab R, Weiller C, Rother J (2003) The influence of extra-and intracranial artery disease on the BOLD signal in FMRI. Neuroimage 20: 1393–1399

    Article  PubMed  Google Scholar 

  24. Hertz-Pannier L, Gaillard WD, Mott SH, Cuenod CA, Bookheimer SY, Weinstein S, Conry J, Papero PH, Schiff SJ, Le Bihan D, Theodore WH (1997) Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study. Neurology 48: 1003–1012

    Article  PubMed  CAS  Google Scholar 

  25. Hoge RD, Atkinson J, Gill B, Crelier GR, Marrett S, Pike GB (1999) Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. Proc Natl Acad Sci USA 96: 9403–9408

    Article  PubMed  CAS  Google Scholar 

  26. Holodny AI, Schulder M, Liu WC, Wolko J, Maldjian JA, Kalnin AJ (2000) The effect of brain tumors on BOLD functional MR imaging activation in the adjacent motor cortex: implications for image-guided neurosurgery. Am J Neuroradiol 21: 1415–1422

    PubMed  CAS  Google Scholar 

  27. Hou BL, Bradbury M, Peck KK, Petrovich NM, Gutin PH, Holodny AI (2006) Effect of brain tumor neovasculature defined by rCBV on BOLD fMRI activation volume in the primary motor cortex. Neuroimage 32: 489–497

    Article  PubMed  Google Scholar 

  28. Jiang Z, Krainik A, David O, Salon C, Tropres I, Hoffmann D, Pannetier N, Barbier EL, Bombin ER, Warnking J, Pasteris C, Chabardes S, Berger F, Grand S, Segebarth C, Gay E, Le Bas JF (2010) Impaired fMRI activation in patients with primary brain tumors. Neuroimage 52: 538–548

    Article  PubMed  Google Scholar 

  29. Kim MJ, Holodny AI, Hou BL, Peck KK, Moskowitz CS, Bogomolny DL, Gutin PH (2005) The effect of prior surgery on blood oxygen level-dependent functional MR imaging in the preoperative assessment of brain tumors. Am J Neuroradiol 26: 1980–1985

    PubMed  Google Scholar 

  30. Krainik A, Lehericy S, Duffau H, Vlaicu M, Poupon F, Capelle L, Cornu P, Clemenceau S, Sahel M, Valery CA, Boch AL, Mangin JF, Bihan DL, Marsault C (2001) Role of the supplementary motor area in motor deficit following medial frontal lobe surgery. Neurology 57: 871–878

    Article  PubMed  CAS  Google Scholar 

  31. Krainik A, Lehericy S, Duffau H, Capelle L, Chainay H, Cornu P, Cohen L, Boch AL, Mangin JF, Le Bihan D, Marsault C (2003) Postoperative speech disorder after medial frontal surgery: role of the supplementary motor area. Neurology 60: 587–594

    Article  PubMed  CAS  Google Scholar 

  32. Krainik A, Duffau H, Capelle L, Cornu P, Boch AL, Mangin JF, Le Bihan D, Marsault C, Chiras J, Lehericy S (2004) Role of the healthy hemisphere in recovery after resection of the supplementary motor area. Neurology 62: 1323–1332

    Article  PubMed  CAS  Google Scholar 

  33. Krainik A, Hund-Georgiadis M, Zysset S, von Cramon DY (2005) Regional impairment of cerebrovascular reactivity and BOLD signal in adults after stroke. Stroke 36: 1146–1152

    Article  PubMed  Google Scholar 

  34. Lavi S, Gaitini D, Milloul V, Jacob G (2006) Impaired cerebral CO2 vasoreactivity: association with endothelial dysfunction. Am J Physiol Heart Circ Physiol 291: H1856–1861

    Article  PubMed  CAS  Google Scholar 

  35. Le Bihan D (2007) The “wet mind”: water and functional neuroimaging. Phys Med Biol 52: R57–90

    Article  PubMed  Google Scholar 

  36. Lehericy S, Duffau H, Cornu P, Capelle L, Pidoux B, Carpentier A, Auliac S, Clemenceau S, Sichez JP, Bitar A, Valery CA, Van Effenterre R, Faillot T, Srour A, Fohanno D, Philippon J, Le Bihan D, Marsault C (2000) Correspondence between functional magnetic resonance imaging somatotopy and individual brain anatomy of the central region: comparison with intraoperative stimulation in patients with brain tumors. J Neurosurg 92: 589–598

    Article  PubMed  CAS  Google Scholar 

  37. Lehericy S, Biondi A, Sourour N, Vlaicu M, du Montcel ST, Cohen L, Vivas E, Capelle L, Faillot T, Casasco A, Le Bihan D, Marsault C (2002) Arteriovenous brain malformations: is functional MR imaging reliable for studying language reorganization in patients? Initial observations. Radiology 223: 672–682

    Article  PubMed  Google Scholar 

  38. Liu TT, Frank LR, Wong EC, Buxton RB (2001) Detection power, estimation efficiency, and predictability in event-related fMRI. Neuroimage 13: 759–773

    Article  PubMed  CAS  Google Scholar 

  39. Liu WC, Feldman SC, Schulder M, Kalnin AJ, Holodny AI, Zimmerman A, Sinensky R, Rao S (2005) The effect of tumour type and distance on activation in the motor cortex. Neuroradiology 47: 813–819

    Article  PubMed  Google Scholar 

  40. Logothetis NK (2008) What we can do and what we cannot do with fMRI. Nature 453: 869–878

    Article  PubMed  CAS  Google Scholar 

  41. Ludemann L, Forschler A, Grieger W, Zimmer C (2006) BOLD signal in the motor cortex shows a correlation with the blood volume of brain tumors. J Magn Reson Imaging 23: 435–443

    Article  PubMed  Google Scholar 

  42. Mangia S, Di Salle F, Garreffa G, Esposito F, Giove F, Cirillo S, Scarabino T, Morrone R, Maraviglia B (2004) Perfusion-and BOLD-based fMRI in the study of a human pathological model for task-related flow reductions. Brain Res Bull 63: 1–5

    Article  PubMed  CAS  Google Scholar 

  43. Matthews PM, Honey GD, Bullmore ET (2006) Applications of fMRI in translational medicine and clinical practice. Nat Rev Neurosci 7: 732–744

    Article  PubMed  CAS  Google Scholar 

  44. Miller G (2008) Neuroimaging. Growing pains for fMRI. Science 320: 1412–1414

    Article  PubMed  CAS  Google Scholar 

  45. Ogawa S, Lee TM, Kay AR, Tank DW (1990) Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci USA 87: 9868–9872

    Article  PubMed  CAS  Google Scholar 

  46. Ogawa S, Tank DW, Menon R, Ellermann JM, Kim SG, Merkle H, Ugurbil K (1992) Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci USA 89: 5951–5955

    Article  PubMed  CAS  Google Scholar 

  47. Ramsey NF, Kirkby BS, Van Gelderen P, Berman KF, Duyn JH, Frank JA, Mattay VS, Van Horn JD, Esposito G, Moonen CT, Weinberger DR (1996) Functional mapping of human sensorimotor cortex with 3D BOLD fMRI correlates highly with H2(15)O PET rCBF. J Cereb Blood Flow Metab 16: 755–764

    Article  PubMed  CAS  Google Scholar 

  48. Rombouts SA, Goekoop R, Stam CJ, Barkhof F, Scheltens P (2005) Delayed rather than decreased BOLD response as a marker for early Alzheimer’s disease. Neuroimage 26: 1078–1085

    Article  PubMed  Google Scholar 

  49. Rossini PM, Altamura C, Ferretti A, Vernieri F, Zappasodi F, Caulo M, Pizzella V, Del Gratta C, Romani GL, Tecchio F (2004) Does cerebrovascular disease affect the coupling between neuronal activity and local haemodynamics? Brain 127: 99–110

    Article  PubMed  CAS  Google Scholar 

  50. Sakatani K, Murata Y, Fujiwara N, Hoshino T, Nakamura S, Kano T, Katayama Y (2007) Comparison of bloodoxygen-level-dependent functional magnetic resonance imaging and near-infrared spectroscopy recording during functional brain activation in patients with stroke and brain tumors. J Biomed Opt 12: 062110

    Article  PubMed  Google Scholar 

  51. Silvestrini M, Pasqualetti P, Baruffaldi R, Bartolini M, Handouk Y, Matteis M, Moffa F, Provinciali L, Vernieri F (2006) Cerebrovascular reactivity and cognitive decline in patients with Alzheimer disease. Stroke 37: 1010–1015

    Article  PubMed  Google Scholar 

  52. Stippich C, Freitag P, Kassubek J, Soros P, Kamada K, Kober H, Scheffler K, Hopfengartner R, Bilecen D, Radu EW, Vieth JB (1998) Motor, somatosensory and auditory cortex localization by fMRI and MEG. Neuroreport 9: 1953–1957

    Article  PubMed  CAS  Google Scholar 

  53. Ulmer JL, Krouwer HG, Mueller WM, Ugurel MS, Kocak M, Mark LP (2003) Pseudo-reorganization of language cortical function at fMR imaging: a consequence of tumor-Induced neurovascular uncoupling. Am J Neuroradiol 24: 213–217

    PubMed  Google Scholar 

  54. Ulmer JL, Hacein-Bey L, Mathews VP, Mueller WM, DeYoe EA, Prost RW, Meyer GA, Krouwer HG, Schmainda KM (2004) Lesion-induced pseudo-dominance at functional magnetic resonance imaging: implications for preoperative assessments. Neurosurgery 55: 569–579; discussion 580–561

    Article  PubMed  Google Scholar 

  55. van der Zande FH, Hofman PA, Backes WH (2005) Mapping hypercapnia-induced cerebrovascular reactivity using BOLD MRI. Neuroradiology 47: 114–120

    Article  PubMed  Google Scholar 

  56. Van Horn JD, Poldrack RA (2009) Functional MRI at the crossroads. Int J Psychophysiol 73: 3–9

    Article  PubMed  Google Scholar 

  57. Vaz R, Borges N, Sarmento A, Azevedo I (1996) Reversion of phenotype of endothelial cells in brain tissue around glioblastomas. J Neurooncol 27: 127–132

    Article  PubMed  CAS  Google Scholar 

  58. Wellmer J, Weber B, Urbach H, Reul J, Fernandez G, Elger CE (2009) Cerebral lesions can impair fMRI-based language lateralization. Epilepsia 50: 2213–2224

    Article  PubMed  Google Scholar 

  59. Yacoub E, Ugurbil K, Harel N (2006) The spatial dependence of the poststimulus undershoot as revealed by high-resolution BOLD-and CBV-weighted fMRI. J Cereb Blood Flow Metab 26: 634–644

    Article  PubMed  Google Scholar 

  60. Ye Y, Zhuo Y, Xue R, Zhou XJ (2010) BOLD fMRI using a modified HASTE sequence. Neuroimage 49: 457–466

    Article  PubMed  Google Scholar 

  61. Zou P, Mulhern RK, Butler RW, Li CS, Langston JW, Ogg RJ (2005) BOLD responses to visual stimulation in survivors of childhood cancer. Neuroimage 24: 61–69

    Article  PubMed  Google Scholar 

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Authors
  1. Alexandre Krainik
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Editors and Affiliations

  1. Department of Neurosurgery, Hôital Gui de Chauliac CHU Montpellier, Montpellier, France

    Hugues Duffau MD, PhD

  2. Institute of Neuroscience of Montpellier INSERM U1051, Plasticity of Central Nervous System, Human Stem Cells and Glial Tumors, Hôital Saint Eloi CHU Montpellier, Montpellier, France

    Hugues Duffau MD, PhD

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Krainik, A. (2011). Functional MRI. In: Duffau, H. (eds) Brain Mapping. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0723-2_4

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  • DOI: https://doi.org/10.1007/978-3-7091-0723-2_4

  • Publisher Name: Springer, Vienna

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