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Historical Review

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Multiple System Atrophy

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Abstract

Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disease characterised by parkinsonian, cerebellar, dysautonomic and pyramidal features in any combination. Predominant features may change over time, and all of them might become manifest as the disease progresses. The historical roots of MSA date back to the early twentieth century, but reflecting the disease protean clinical presentation, it took almost a century for a definite nosological and pathological definition of MSA to be developed.

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Authors and Affiliations

  1. Department of Neuroscience, Mental Health and Sensory Organs, “Sapienza” University of Rome, Rome, Italy

    Alessandra Fanciulli MD

  2. Division of Neurobiology, Department of Neurology, Innsbruck Medical University, Anichstrasse 35, Innsbruck, 6020, Austria

    Alessandra Fanciulli MD & Gregor K. Wenning MD, PhD, MSC

Authors
  1. Alessandra Fanciulli MD
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  2. Gregor K. Wenning MD, PhD, MSC
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Correspondence to Alessandra Fanciulli MD .

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Editors and Affiliations

  1. Division of Clinical Neurobiology, Innsbruck Medical University, Innsbruck, Austria

    Gregor K. Wenning

  2. Department of Neurology Division of Neurobiology, Innsbruck Medical University, Innsbruck, Austria

    Alessandra Fanciulli

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© 2014 Springer-Verlag Wien

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Fanciulli, A., Wenning, G.K. (2014). Historical Review. In: Wenning, G., Fanciulli, A. (eds) Multiple System Atrophy. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0687-7_1

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  • DOI: https://doi.org/10.1007/978-3-7091-0687-7_1

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  • Publisher Name: Springer, Vienna

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  • Online ISBN: 978-3-7091-0687-7

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