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Brain Edema XII pp 347–350Cite as

L-8 is a key mediator of neuroinflammation in severe traumatic brain injuries

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Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 86))

Abstract

The subjects were 22 patients with severe head injury. The average age was 45 ± 18.3 years. There were 13 survivors and 9 fatalities. Samples of peripheral blood and cerebrospinal fluid (CSF) were taken four times, at the time of admission and at 24, 72, and 168 hours later. IL-6: For the survivor group, peripheral blood levels were 181, 105, 37, and 26 pg/ml, respectively (median values). CSF levels were 5376, 3565, 328, and 764 pg/ml, respectively. For the fatality group, peripheral blood levels were 102, 176, 873, and 3059 pg/ml, respectively, whereas CSF levels were 15241, 97384, 548225, and 366500 pg/ml, respectively. IL-8: For the survivor group, peripheral blood levels were 36, 15, 15, and 15 pg/ml, respectively, whereas CSF levels were 23736, 4074, 355, and 1509 pg/ml, respectively. For the fatality group, peripheral blood levels were 21, 28, 43, and 77 pg/ml, respectively, whereas CSF levels were 29003, 8906, 5852, and 8220 pg/ml, respectively. IL-6 and IL-8 levels were significantly higher after 72 hours in the fatality group. The fact that CSF IL-8 was 1000 times that in the peripheral blood at the time of admission, and decreased thereafter, indicates that IL-8 is a key mediator of neuroinflammation.

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Author information

Authors and Affiliations

  1. Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan

    Hidehiko Kushi, T. Saito, K. Makino & N. Hayashi

Authors
  1. Hidehiko Kushi
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  2. T. Saito
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  3. K. Makino
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  4. N. Hayashi
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Corresponding author

Correspondence to Hidehiko Kushi .

Editor information

Editors and Affiliations

  1. Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

    T. Kuroiwa

  2. Institute für Chirurgische Forschung, Ludwig-Maximilians-Universität, München, Germany

    A. Baethmann

  3. Department of Neurosurgery, Polish Academy of Scienes, Warsaw, Poland

    Z. Czernicki

  4. Section of Neurosurgery, University of Michigan, Ann Arbor, USA

    J. T. Hoff

  5. Department of Neurosurgery, Musashino Red Cross Hospital, Tokyo, Japan

    U. Ito

  6. Department of Neurological Surgery, Nihon University, Tokyo, Japan

    Y. Katayama

  7. Medical College of Virgina, Richmond, USA

    A. Marmarou

  8. Department of Neurosurgery, Newcastle Gerneral Hospital, Newcastle-upon-Tyne, UK

    B. A. D. Mendelow

  9. Neurochirurgische Universitätklinik, Ludwig-Maximilians-Universität, München, Germany

    H.-J. Reulen

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© 2003 Springer-Verlag Wien

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Kushi, H., Saito, T., Makino, K., Hayashi, N. (2003). L-8 is a key mediator of neuroinflammation in severe traumatic brain injuries. In: Kuroiwa, T., et al. Brain Edema XII. Acta Neurochirurgica Supplements, vol 86. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0651-8_74

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  • DOI: https://doi.org/10.1007/978-3-7091-0651-8_74

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7220-9

  • Online ISBN: 978-3-7091-0651-8

  • eBook Packages: Springer Book Archive

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