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Brain Edema XII pp 297–299Cite as

Prions prevent brain damage after experimental brain injury: a preliminary report

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Part of the Acta Neurochirurgica Supplements book series (NEUROCHIRURGICA,volume 86)

Abstract

The physiological function of the normal cellular form of prion protein (PrpC) is not yet fully understood. In the current study we used prion protein gene knock-out mice (Prnp -/-) to assess the role of PrpC in traumatic brain injury. Prnp +/- and Prnp -/- mice were subjected to weight-drop contusional brain injury over the left parietal cortex. Prnp -/- mice manife sted a significantly larger lesion volume and worse neuromotor scores than did their Prnp +/- littermates. IgG immunostaining revealed that in Prnp -/- mice the breakdown in the blood-brain barrier (BBB) was more exten sive at 1 month after brain injury. Our results are in agreement with previous in vitro findings of the neuroprotective role of PrpC and further support the hypothesis that functional loss of PrpC plays a pathogenic role in prion diseases. We also suggest that PrpC modulates BBB function.

Keywords

  • Blood-brain barrier
  • IgG
  • mouse
  • prion
  • traumatic brain injury

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Nippon Medical School, Tokyo, Japan

    Shigeru Hoshino M.D., Ph.D., T. Asakura & A. Teramoto

  2. Laboratory for Behavioural Genetics, Brain Research Institute, RIKEN, Wako, Saitama, Japan

    K. Inoue & S. Itohara

  3. National Institute of Animal Health, Tsukuba, Ibaraki, Japan

    T. Yokoyama

  4. Department of Neurosurgery, Nippon Medical School, Chiba Hokusoh Hospital, Inaba, Chiba, Japan

    S. Kobayashi

Authors
  1. Shigeru Hoshino M.D., Ph.D.
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  2. K. Inoue
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  3. T. Yokoyama
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  4. S. Kobayashi
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  5. T. Asakura
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  6. A. Teramoto
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  7. S. Itohara
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Corresponding author

Correspondence to Shigeru Hoshino M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

    T. Kuroiwa

  2. Institute für Chirurgische Forschung, Ludwig-Maximilians-Universität, München, Germany

    A. Baethmann

  3. Department of Neurosurgery, Polish Academy of Scienes, Warsaw, Poland

    Z. Czernicki

  4. Section of Neurosurgery, University of Michigan, Ann Arbor, USA

    J. T. Hoff

  5. Department of Neurosurgery, Musashino Red Cross Hospital, Tokyo, Japan

    U. Ito

  6. Department of Neurological Surgery, Nihon University, Tokyo, Japan

    Y. Katayama

  7. Medical College of Virgina, Richmond, USA

    A. Marmarou

  8. Department of Neurosurgery, Newcastle Gerneral Hospital, Newcastle-upon-Tyne, UK

    B. A. D. Mendelow

  9. Neurochirurgische Universitätklinik, Ludwig-Maximilians-Universität, München, Germany

    H.-J. Reulen

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© 2003 Springer-Verlag Wien

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Hoshino, S. et al. (2003). Prions prevent brain damage after experimental brain injury: a preliminary report. In: , et al. Brain Edema XII. Acta Neurochirurgica Supplements, vol 86. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0651-8_64

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  • DOI: https://doi.org/10.1007/978-3-7091-0651-8_64

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7220-9

  • Online ISBN: 978-3-7091-0651-8

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