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Effect of advanced glycation endproducts on cell cycle and their relevance for Alzheimer’s disease

  • Conference paper
Advances in Research on Neurodegeneration

Part of the book series: Journal of Neural Transmission. Supplementa ((NEURAL SUPPL,volume 65))

Summary

In Alzheimer’s disease, neurons in affected regions re-enter the cell cycle, leave the G0 state and appear to be arrested at both the G1/S and G2/M phase with resulting cell death, predominantly by apoptosis. Further hallmarks of AD are crosslinked protein deposits (amyloid plaques and neurofibrillary tangles), which time-dependently become modified by “advanced glycation endproducts (AGEs)”. Since AGEs activate both mitogenic and redox-sensitive pathways, they might be involved both in cell cycle re-entry and arrest.

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Abbreviations

Aβ):

β-amyloid peptide

AD):

Alzheimer’s disease

AGEs):

advanced glycation endproducts

APP):

amyloid precursor protein

GSH):

reduced lutathione

MAP):

microtubuli associated protein tai

NFT):

neurofibrillary tangles

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Author information

Authors and Affiliations

  1. Neuroimmunological Cell Biology Unit, IZKF Leipzig, Germany

    PD Dr. G. Münch & J. Gasic-Milenkovic

  2. Department of Neuroanatomy, Paul-Flechsig-Institut für Hirnforschung, University of Leipzig, Germany

    T. Arendt

  3. Neuroimmunological Cell Biology, Interdis-ciplinary Center of Clinical Research (IZKF), Johannisallee 30a, D-04103, Leipzig, Germany

    PD Dr. G. Münch

Authors
  1. PD Dr. G. Münch
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  2. J. Gasic-Milenkovic
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  3. T. Arendt
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Editor information

Editors and Affiliations

  1. Neurobiotec, Berlin, Federal Republic of Germany

    R. Horowski

  2. Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan

    Y. Mizuno

  3. Department of Neurology, The Mount Sinai Medical Center, New York, NY, USA

    C. W. Olanow

  4. Department of Neurology, University of Innsbruck, Innsbruck, Austria

    W. H. Poewe

  5. Department of Psychiatry, University of Würzburg, Würzburg, Federal Republic of Germany

    P. Riederer

  6. Neurodegenerative Disorders Centre, The University of British Columbia, Vancouver, B.C., Canada

    J. A. Stoessl

  7. Department of Pharmacology, Technion — Israel Institute of Technology, Haifa, Israel

    M. B. H. Youdim

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© 2003 Springer-Verlag Wien

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Münch, G., Gasic-Milenkovic, J., Arendt, T. (2003). Effect of advanced glycation endproducts on cell cycle and their relevance for Alzheimer’s disease. In: Horowski, R., et al. Advances in Research on Neurodegeneration. Journal of Neural Transmission. Supplementa, vol 65. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0643-3_4

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  • DOI: https://doi.org/10.1007/978-3-7091-0643-3_4

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83907-2

  • Online ISBN: 978-3-7091-0643-3

  • eBook Packages: Springer Book Archive

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