Combined endoscopic surgery and radiosurgery as a treatment modality of olfactory neuroblastoma (esthesioneuroblastoma)

  • F. UngerEmail author
  • C. Walch
  • H. Stammberger
  • K. Haselsberger
  • G. Papaefthymiou
Conference paper


Microsurgical techniques have considerably improved the results from surgical treatment of esthesioneuroblastoma (olfactory neuroblastoma). Nevertheless, these rare tumours of the frontal skull base are still associated with high rates of tumour recurrence and mortality, thus remaining a challenge even for experienced surgeons. A novel therapeutic approach that combines endoscopic sinus surgery and radiosurgery (Gamma Knife) is presented here.


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  1. 1.
    Anderhuber W, Stammberger H, Walch C, Fock C, Regauer S, Luxenberger W, Gotschuli A (1999) Rigid endoscopy in minimally invasive therapy of tumours of the paranasal sinuses and skull base. Min Invas Ther Allied Technol 8: 25–32CrossRefGoogle Scholar
  2. 2.
    Devaiah AK, Larsen C, Tawfik O, O’Boynick P, Hoover LA (2003) Esthesioneuroblastoma: endoscopic nasal and anterior craniotomy resection. Laryngoscope 113: 2086–2090PubMedCrossRefGoogle Scholar
  3. 3.
    Dulguerov P, Calcaterra T (1990) Esthesioneuroblastoma: the UCLA experience 1970–1990. Laryngoscope 102: 843–849CrossRefGoogle Scholar
  4. 4.
    Ebersold MJ, Olsen KD, Foote RL, Buckner JC, Quast LM (1995) Esthesioneuroblastoma. In: Kye AH, Laws ER Jr (eds) Brain tumours: an encyclopedic approach. Churchill Livingstone, New York, pp 825–838Google Scholar
  5. 5.
    Hyams VJ (1998) Tumours of the upper respiratory tract and ear. In: Hyams VJ, Batsakis JG, Michaels L (eds) Atlas of tumour pathology, second series, fascicle 25. Armed Forces Institute of Pathology, Washington, pp 240–248Google Scholar
  6. 6.
    Kadish S, Goodman M, Wang CC (1976) Olfactory neuroblastoma. A clinical analysis of 17 cases. Cancer 37: 1571–1576PubMedCrossRefGoogle Scholar
  7. 7.
    Lund VJ, Howard D, Wei W, Spittle M (2003) Olfactory neuroblastoma: past, present, and future ? Laryngoscope 113: 502–507PubMedCrossRefGoogle Scholar
  8. 8.
    Muacevic A, Kreth FW, Horstmann GA, Schmid-Elsaesser R, Wowra B, Steiger HJ, Reulen HJ (1999) Surgery and radiotherapy compared with gamma knife radiosurgery in the treatment of solitary cerebral metastases of small diameter. J Neurosurg 91: 35–43PubMedCrossRefGoogle Scholar
  9. 9.
    Unger F, Walch C, Stammberger H, Papaefthymiou G, Haselsberger K, Pendl G (2001) Olfactory neuroblastoma (esthesioneuroblastoma): report of six cases treated by a novel combination of endoscopic surgery and radiosurgery. Minim Invas Neurosurg 44: 79–84CrossRefGoogle Scholar
  10. 10.
    Walch C, Stammberger H, Anderhuber W, Unger F, Köle W, Feichtinger K (2000) The minimally invasive approach to olfactory neuroblastoma: combined endoscopic and stereotactic treatment. Laryngoscope 110: 635–640PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 2004

Authors and Affiliations

  • F. Unger
    • 1
    Email author
  • C. Walch
    • 2
  • H. Stammberger
    • 2
  • K. Haselsberger
    • 1
  • G. Papaefthymiou
    • 1
  1. 1.Department of NeurosurgeryMedical UniversityGrazAustria
  2. 2.Department of Ears-Nose-Throat-DiseasesMedical UniversityGrazAustria

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