Advertisement

Vorhersagewerte von Beta-trace Protein (Prostaglandin D Synthase) mittels Laser-Nephelometer zur Identifikation von Liquor

  • G. BachmannEmail author
  • H. Petereit
  • U. Djenabi
  • O. Michel

Zusammenfassung

Liquorfisteln können als Folge von Traumen, chirurgischen Eingriffen, Fehlbildungen oder Tumorwachstum auftreten. In seltenen Fällen bleibt die Ätiologie unbekannt [1–3]. Da Liquorfisteln lebensbedrohlichen Komplikationen vorausgehen, sind diagnostische Werkzeuge zum Nachweis von Liquorspuren erwünscht [4, 5]. Idealerweise sollte die Methode nicht-in-vasiv, nicht-strahlenbelastend und labortechnisch mit kleinen Probenmengen und einem standardisiertem Verfahren durchführbar sein. Nur Labortests unter der Verwendung von Liquormarkern werden diesen Anforderungen gerecht.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Gormley WB, Sekhar LN, Wright DC, Kamerer D, Schessel D (1997) Acoustic neuromas: results of current surgical management. Neurosurgery 41(1): 50–58PubMedCrossRefGoogle Scholar
  2. 2.
    Park TS, Hoffman HJ, Humphreys RP, Chuang H (1982) Spontaneous cerebrospinal fluid otorrhea in association with a congenital defect of the cochlear aqueduct and Mondini dysplasia. Neurosurgery 11(3): 356–362PubMedCrossRefGoogle Scholar
  3. 3.
    Simmen D, Bischoff T, Schuknecht B (1997) Erfahrungen mit der Abklärung von Frontobasisdefekten, ein diagnostisches Konzept. Laryngo-Rhino-Otol 76: 583–587CrossRefGoogle Scholar
  4. 4.
    Crawford C, Kennedy N, Weir WR (1994) Cerebrospinal fluid rhinorrhoea and haemophilus influenzae meningitis 37 years after a head injury. J Infect 28(1): 93–97PubMedCrossRefGoogle Scholar
  5. 5.
    Salca HC, Danaila L (1997) Onset of uncomplicated cerebrospinal fluid fistula 27 years after head injury: case report. Surg Neurol 47(2): 132–133PubMedCrossRefGoogle Scholar
  6. 6.
    Stammberger H, Greistorfer K, Wolf G, Luxenberger W (1997) Operativer Verschluss von Liquorfisteln der vorderen Schädelbasis unter intrathekaler Natriumfluoreszeinanwendung. Laryngo Rhino Otol 76: 595–607CrossRefGoogle Scholar
  7. 7.
    Lanza DC, O’Brian DA, Kennedy DW (1997) Endoscopic repair of cerebrospinal fluid fistulae and encephaloceles. Laryngoscope 106: 1119–1125CrossRefGoogle Scholar
  8. 8.
    Hughes RG, Jones NS, Robertson IJ (1997) The endoscopic treatment of cerebrospinal fluid rhinorrhoea: the Nottingham experience. J Laryngol Otol 111(2): 125–128PubMedCrossRefGoogle Scholar
  9. 9.
    Kelley TF, Stankiewicz JA, Chow JM, Origitano TC, Shea J (1996) Endoscopic closure of postsurgical anterior cranial fossa cerebrospinal fluid leaks. Neurosurgery 39(4): 743–746PubMedCrossRefGoogle Scholar
  10. 10.
    McCormack B, Cooper PR, Persky M, Rothstein S (1990) Extracranial repair of cerebrospinal fluid fistulas: technique and results in 37 patients. Neurosurgery 27(3): 412–417PubMedCrossRefGoogle Scholar
  11. 11.
    Hoffmann A, Conradt HS, Gross G, Nimtz M, Lottspeich F, Wurster U (1993) Purification and chemical characterization of beta-trace protein from human cerebrospinal fluid: its identification as prostaglandin D synthase. J Neurochem 61(2): 451–456PubMedCrossRefGoogle Scholar
  12. 12.
    Bachmann G, Baldus SE, Nekic M, Michel O (1998) Beta-trace protein in human perilymph. In: Reid A, Marchbanks RJ, Ernst A (eds) Intracranial and inner-ear physiology and pathophysiology. Whurr Publ Ltd, London, pp 193–196Google Scholar
  13. 13.
    Huber AR (2000) Zur neuen Diagnostik von Liquorfisteln. HNO 48: 478–488CrossRefGoogle Scholar
  14. 14.
    Bachmann G, Nekic M, Michel O (2000) Clinical experience with beta-trace protein as a marker for cerebrospinal fluid. Ann Otol Rhinol Laryngol 109(12): 1099–1102PubMedGoogle Scholar
  15. 15.
    Petereit HF, Bachmann G, Nekic M, Althaus H, Pukrop R (2001) A new nephelometric assay for beta-trace protein (prostaglandin D synthase) as an indicator of liquorrhoea. J Neurol Neurosurg Psychiatry 71: 347–351PubMedCrossRefGoogle Scholar
  16. 16.
    Kleine TO, Damm T, Althaus H (2000) Quantification of 3-trace protein and detection of transferrin isoforms in mixtures of cerebrospinal fluid and blood serum as models of rhinorrhea and otorrhea diagnosis. Fresenius J Anal Chem 366: 382–386PubMedCrossRefGoogle Scholar
  17. 17.
    Har-El G (1999) What is „spontaneous“ cerebrospinal fluid rhinorrhea? Classification of cerebrospinal fluid leaks. Ann Otol Rhinol Laryngol 108: 323–326PubMedGoogle Scholar
  18. 18.
    Hull HF, Morrow G (1975) Glucorrhea revisited. Prolonged promulgation of another plastic pearl. JAMA 234(10): 1052–1053PubMedCrossRefGoogle Scholar
  19. 19.
    Jones NS, Becker DG (2001) Advances in the management of CSF leaks. BMJ 322(7279): 122–123PubMedCrossRefGoogle Scholar
  20. 20.
    Meurman OH, Irjala K, Suonpaa J, Laurent B (1979) A new method for the identification of cerebrospinal fluid leakage. Acta Otolaryngol 87(3–4): 366–369PubMedCrossRefGoogle Scholar
  21. 21.
    Oberascher G, Arrer E (1986) Immunologische Liquordiagnostik mittels β2-transferrin — Grundlagen und Methodik. Laryng Rhinol Otol 65: 158–161CrossRefGoogle Scholar
  22. 22.
    Nandapalan V, Watson ID, Swift AC (1996) Beta-2-transferrin and cerebrospinal fluid rhinorrhoea. Clin Otolaryngol 21: 259–264PubMedCrossRefGoogle Scholar
  23. 23.
    Skedros DG, Cass SP, Hirsch BE, Kelly RH (1993) Sources of error in use of beta-2 transferrin analysis for diagnosing perilymphatic and cerebral spinal fluid leaks. Otolaryngol Head Neck Surg 109(5): 861–864PubMedGoogle Scholar
  24. 24.
    Clausen J (1961) Proteins in normal cerebrospinal fluid not found in serum. Proc Soc Exp Biol Med 107: 170–172PubMedGoogle Scholar
  25. 25.
    Felgenhauer K, Schädlich HJ, Nekic M (1987) Beta-trace protein as marker for cerebrospinal fluid fistula. Klin Wochenschr 65: 764–768PubMedCrossRefGoogle Scholar
  26. 26.
    Tumani H, Reiber G, Nau R, Prange HW, Kauffmann K, Mäder M, Felgenhauer K (1998) Beta-trace protein concentration in cerebrospinal fluid is decreased in patients with bacterial meningitis. Neurosci Lett 242(l):5–8PubMedCrossRefGoogle Scholar
  27. 27.
    Arrer E, Meco C, Oberascher G, Piotrowski W, Albegger K, Patsch W (2002) Beta-trace protein as a marker for cerebrospinal fluid rhinorrhea. Clin Chem 48(6): 939–941PubMedGoogle Scholar
  28. 28.
    Reiber H, Walther K, Althaus H (2003) Beta-trace protein as sensitive marker for CSF rhinorhea and CSF otorhea. Acta Neurol Scand 108(5): 359–362PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 2004

Authors and Affiliations

  • G. Bachmann
    • 3
    Email author
  • H. Petereit
    • 1
  • U. Djenabi
    • 2
  • O. Michel
    • 2
  1. 1.Klinik und Poliklinik für NeurologieDeutschland
  2. 2.Klinik und Poliklinik für Hals-Nasen-OhrenheilkundeUniversität KölnDeutschland
  3. 3.Øre-Nese-Hals-AvdelingenUniverstitetssykehuset i Nord-NorgeTromsøNorway

Personalised recommendations