Zusammenfassung
Es gibt keine einzelne allgemeingültige Erklärung für das Auftreten einer Sterilitätsproblematik bei Patientinnen mit Endometriose. Bei kritischer Evaluation der vorhandenen Daten kann nicht einmal gefolgert werden, dass eine Endometriose grundsätzlich eine Sterilitätsproblematik nach sich zieht. Dennoch ist seit langem bekannt, dass Endometriose häufiger bei Frauen mit Sterilitätsproblematik als bei fertilen Frauen vorliegt. „Klassische“ Arbeiten konnten zeigen, dass bei 6% bis 58% aller Sterilitätspatientinnen eine Endometriose vorliegt, und dass 30% bis 50% aller Frauen mit Endometriose eine Sterilitätsproblematik auf weisen (Hull et al. 1985; Buttram et al. 1985). Neuere Studien im Rahmen laparoskopischer Eingriffe verglichen das Auftreten von Endometriose bei Sterilitätspatientinnen und bei Patientinnen, die sich zur Tubensterilisation vorstellten. Sie konnten ebenfalls zeigen, dass Endometriose häufiger bei Sterilitätspatientinnen als bei fertilen Frauen auftritt. Eine Vielzahl von Sterilitätsmechanismen, die durch Endometriose verursacht sein könnten, wurde und wird diskutiert (Tabelle 1).
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Literatur
Acosta AA, Buttram VC, Besch PK, Malinak LR, Franklin RR, Vanderheyden JD (1973) A proposed classification of pelvic endometriosis. Obstet Gynecol 42: 19–26
Balasch J, Vanrell JA (1985) Mild endometriosis and luteal function. Int J Fertil 30: 4–6
Beretta P, Franchi M, Ghezzi F, Busacca M, Zupi E, Bolis P (1998) Randomized clinical trial of two laparoscopic treatments of endometriomas: cystectomy versus drainage and coagulation. Fertil Steril 70: 1176–1180
Brosens JA, Koninckx PR, Corvelevyn PA (1978) A study of plasma progesterone, oestradiol-17beta, prolactin and LH levels, and of the luteal phase appearance of the ovaries in patients with endometriosis and infertility. Br J Obstet Gynaecol 85: 246–250
Buttram VC Jr, Reiter RC (1985) Endometriosis. In: Buttram VC Jr, Reiter RC (eds) Surgical treatment of the infertile female. Williams & Wilkins, Baltimore, pp 89–148
Cheong YC, Shelton JB, Laird SM, Richmond M, Kudesia G, Li TC, Ledger WL (2002) IL-1, IL-6 and TNF-a concentrations in the peritoneal fluid of women with pelvic adhesions. Hum Reprod 17: 69–75
Chew PC, Peh KL, Loganath A (1990) Elevated peritoneal fluid luteinizing hormone and prolactin concentrations in infertile women with endometriosis. Int J Gynaecol Obstet 33: 35–39
Deaton JL, Gibson M, Blackmer KM, Nakajima ST, Badger GJ, Brumsted JR (1990) A randomized, controlled trial of clomiphene citrate and intauterine insemination in couples with unexplained infertility or surgically corrected endometriosis. Fertil Steril 54: 28–31
Dicker D, Goldman JA, Levy T, Feldberg D, Ashkenazi J (1992) The impact of long-term gonadotropin-releasing hormone analogue treatment on preclinical abortions in patients with severe endometriosis undergoing in vitro fertilization-embryo transfer. Fertil Steril 57: 597–600
Dmowski WP, Radwanska E, Binor A, Rana N (1986) Mild endometriosis and ovulatory dysfunction: effect of danazol treatment on success of ovulation induction. Fertil Steril 46: 784–789
Fabregues F, Balasch J, Creus M, Civico S, Carmona F, Puerot, B., Vanrell JA (1998) Long-term down-regulation does not improve pregnancy rates in an invitro fertilization program. Fertil Steril 70: 46–51
Fedele L, Bianchi S, Marchini M, Villa L, Brioschi D, Parazzini F (1992) Superovulation with human menopausal gonadotropins in the treatment of infertility associated with minimal or mild endometriosis: a controlled randomized study. Fertil Steril 58: 28–31
FitzSimmons J, Stahl R, Gocial B, Shapiro SS (1987) Spontaneous abortion and endometriosis. Fertil Steril 47: 696–698
Gazvani MR, Christmas S, Quenby S, Kirwan J, Johnson PM, Kingsland CR (1998) Peritoneal fluid concentration of interleuin-8 in women with endometriosis: relationship to stage of disease. Hum Reprod 13: 1957–1961
Groll M (1984) Endometriosis and spontaneous abortion. Fertil Steril 41: 933–935
Haney AF, Muscato JJ, Weinberg JB (1981) Peritoneal fluid cell populations in infertility patients. Fertil Steril 35: 696–698
Haney AF, Handwerger S, Weinberg JB (1984) Peritoneal fluid prolactin in infertile women with endometriosis: lack of evidence of secretory activity by endometrial implants. Fertil Steril 42: 935–938
Hemmings R, Bissonnette F, Bouzayen R (1998) Results of laparoscopic treatments of ovarian endometriomas: laparoscopic ovarian fenestration and coagulation. Fertil Steril 70: 527–529
Hirschowitz JS, Soler NG, Wortsman J (1978) The galactorrhea-endometriosis syndrome. Lancet 1: 896–898
Hornung D, Dohrn K, Sotlar K, Greb RR, Wallwiener D, Kiesel L, Taylor RN (2000) Localization in tissues and secretion of eotaxin by cells from normal endometrium and endometriosis. J Clin Endocrin Metab 85: 2604–2608
Hughes E, Fedorkow D, Collins J, Vanderkerckhone P (2000) Ovulation suppression for endometriosis. In: The Cochrane Library, Issue 1. Update Software, Oxford
Hull MGR, Glazener CMA, Kelly NJ et al. (1985) Population study of causes, treatment, and outcome of infertility. Brit Med J 291: 1693–1697
Issacs JD Jr, Hines RS, Sopelak VM, Cowan BD (1997) Ovarian endometriomas does not adversely affect pregnancy success following treatment with in vitro fertilization. J Assist Reprod Genet 14: 551–553
Ishimaru T, Masuzaki H, Samejima T, Fujishta A, Nakamura K, Yamabe T (1994) Influence of ovarian endometrioma on fertility. Am J Obstet Gynecol 171/2: 541–545
Inoue M, Kobayashi Y, Honda I, Awaji H, Fujii A (1992) The impact of endometriosis on the reproductive outcome of infertile patients. Am J Obstet Gynecol 167: 278–282
Jansen RPS (1986) Minimal endometriosis and reduced fecundability: prospective evidence from an artificial insemination by donor program. Fertil Steril 46: 141–143
Kim CH, Cho YK, Mok JE (1996) Simplified ultralong protocol of gonadotrophinreleasing hormone agonist for ovulation induction with intrauterine insemination in patients with endometriosis. Hum Reprod 11: 398–402
Khorram O, Taylor RN, Ryan IP, Schall TJ, Landers DV (1993) Peritoneal fluid concentrations of the cytokines RANTES correlate with the severity of endometriosis. Am J Obstet Gynecol 169: 1545–1549
Lebovic DI, Mueller MD, Taylor RN (2001) Immunobiology of endometriosis. Fertil Steril 75: 1–10
Lehmann-Willenbrock E (2000) Die pelviskopische Tubenkorrektur bei Endometrios-patientinnen mit Sterilität. In: Mettler L (Hrsg) Endometriose. pmi Verlag, Frankfurt Moskau Sennwald Wien, S 182–188
Loh RH, Tan AT, Kumar J, Ng SC (1999) Ovarian response after laparoscopic ovarian cystectomy for endometriotic cysts in 132 monitored cycles. Fertil Steril 72: 316–321
Marcoux S, Maheux R, Berube S, et al (1997) Canadian Collaborative Group in Endometriosis. Laparoscopic surgery in infertile women with minimal or mild endometriosis. New Eng J Med 377: 217–222
Marcus SF, Edwards RG (1994) High rates of pregnancy after long-term down-regulation of women with severe endometriosis. Am J Obstet Gynecol 171: 812–817
McLaren J, Prentice A, Charnock-Jones DS, Smith SK (1996) Vascular endothelial growth factor (VEGF) concentrations are elevated in peritoneal fluid of women with endometriosis. Hum Reprod 11: 220–223
Metzger DA, Olive DL, Stohs GF et al. (1986) Association of endometriosis and spontaneous abortion: effect of control group selection. Fertil Steril 45: 18–22
Oosterlynck DJ, Meuleman C, Sobis H, Vandeputte, Koninckx PR (1993) Angiogenic activity of peritoneal fluid from women with endometriosis. Fertil Steril 59: 778–782 Parazzini F and the Gruppo Italiano per lo Studio dell'Endometriosis (1999) Ablation of lesions or no treatment in minimal-mild endometriosis in infertile women: a randomized trial. Hum Reprod 14: 1332–1334
Schultze D, Kleinstein J (2000) Schwangerschaftsraten nach ultralanger GnRH-Analoga Therapie bei Frauen mit Endometriosestadien II-IV (rAFS) In: Mettler L (Hrsg) Endometriose. pmi Verlag, Frankfurt Moskau Sennwald Wien, S 234–239
Shifren JL, Tseng JF, Zaloudek CJ, et al (1996) Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrinol Metab 81: 3112–3118
Soules MR, Malinak LR, Bury R, et al (1976) Endometriosis and anovulation: a coexisting problem in the infertile female. Am J Obstet Bynecol 125: 412–417
Thomas EJ, Lenton EA, Cooke ID (1986) Follicle growth patterns and endocrinologic abnormalities in infertile women with minor degrees of endometriosis. Br J Obstet Gynaecol 93: 852–858
Tinkanen H, Kujansuu E (2000) In vitro fertilization in patients with ovarian endometriomas. Acta Obstet Gynecol Scand 79: 119–122
Toma SK, Stovall DW, Hammond MG (1992) The effect of laparoscopic ablation or danocrine on pregnancy rates in patients with stage I or II endometriosis undergoing donor insemination. Obstet Gynecol 80: 253–256
Tummon IS, Asher LJ, Martin JS, Tulandi T (1997) Randomized controlled trial of superovulation and insemination in couples with unexplained infertility or surgically corrected endometriosis. Fertil Steril 68: 8–12
Wheeler JM, Johnston BM, Malinak LR (1983) The relationship of endometriosis to spontaneous abortion. Fertil Steril 39: 656–660
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Brucker, C. (2004). Endometriose und Kinderlosigkeit. In: Endometriose. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0574-0_4
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DOI: https://doi.org/10.1007/978-3-7091-0574-0_4
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