Modeling Ca2+ Microdomains

  • Jens Christian BrasenEmail author
  • Jens C. B. Jacobsen
  • Niels-Henrik Holstein-Rathlou


The intracellular ionic concentrations are often regarded as being uniform across the cytosol. In recent years it has become evident, however, that there are local spaces within the cell where the concentration of free Ca2+can temporarily exceed the bulk concentration in the cytosol by orders of magnitudes and that these localized regions of high Ca2+concentration play important functional roles.


Endoplasmatic Reticulum Dendritic Spine Plasma Membrane Potential TRPM2 Channel Depolarize Membrane Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Preparation of this chapter was supported by The Danish Council for Independent Research, Medical Sciences grant nr. 10-082148.


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Copyright information

© Springer-Verlag/Wien 2011

Authors and Affiliations

  • Jens Christian Brasen
    • 1
    Email author
  • Jens C. B. Jacobsen
    • 1
  • Niels-Henrik Holstein-Rathlou
    • 1
  1. 1.Panum InstituteUniversity of CopenhagenCopenhagenDenmark

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