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Senescence

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Melanoma Development

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Abstract

Cellular senescence is a program initiated by many stress signals including aberrant activation of oncogenes, DNA damage, oxidative lesions and telomere attrition. Once engaged senescence irreversibly limits cellular proliferation and can potently prevent tumour formation in vivo. The precise mechanisms driving senescence are still not completely defined, although the pRb and p53 tumour suppressor pathways are critical effectors. Senescent cells also develop aberrant gene expression profiles and acquire pro-inflammatory behaviour that may contribute to organismal ageing and age-related diseases, including cancer. It is not yet clear whether the pro-ageing actions of senescent cells can be minimised in vivo, but the therapeutic potential of this stress-induced program may depend on establishing a new equilibrium that favours tumour suppressor activity.

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Acknowledgements

Our work is supported by the National Health and Medical Research Council of Australia (NHMRC), the Cancer Council of New South Wales. HR is a Cancer Institute of NSW Fellow.

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  1. Westmead Institute for Cancer Research and Melanoma Institute of Australia, University of Sydney at Westmead, Westmead, NSW, 2145, Australia

    Helen Rizos

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  1. Helen Rizos
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  2. Lyndee L. Scurr
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Correspondence to Helen Rizos .

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  1. , Molecular Pathology, Institute of Pathololgy, Franz-Josef-Strauss-Allee 11, Regensburg, 93053, Germany

    Anja Bosserhoff

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Rizos, H., Scurr, L.L. (2011). Senescence. In: Bosserhoff, A. (eds) Melanoma Development. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0371-5_11

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