Abstract
Purpose: The temporal profiles of the effects of intracisternal injection of magnesium sulfate (MgSO4) on vasodilation and cerebrospinal fluid (CSF) magnesium ion (Mg2+) concentration were investigated in the canine subarachnoid hemorrhage (SAH) model.
Method: Cerebral vasospasm was induced using the two-hemorrhage model in seven female beagles. On day 7, 0.5 ml/kg of 15 mmol/l MgSO4 in Ringer solution was injected into the cerebellomedullary cistern. Angiography was performed on day 1 (before SAH), and before and 1, 3, and 6 h after the intracisternal injection on day 7. CSF Mg2+ was measured at the same time.
Results: The diameters of the basilar artery (BA), vertebral artery (VA), and superior cerebellar artery (SCA) before the intracisternal injection on day 7 were 0.59 ± 0.15, 0.41 ± 0.17, and 0.35 ± 0.17 mm, respectively, and were significantly decreased (p < 0.01) compared with the baseline diameters on day 1. The BA diameters at 1 h (0.74 ± 0.16 mm) and 3 h (0.73 ± 0.13 mm), the VA diameter at 1 h (0.64 ± 0.14 mm), and the SCA diameter at 3 h (0.54 ± 0.08 mm) after the injection were significantly increased (p < 0.05). The CSF Mg2+ concentration was significantly increased (p < 0.01) at 1 h (3.59 ± 0.76 mEq/l) and 3 h (2.00 ± 0.31 mEq/l) after the injection compared with the baseline value (1.35 ± 0.23 mEq/l).
Conclusions: The reversible effect of intracisternal MgSO4 solution injection on the spastic artery depends on maintenance of the optimal CSF Mg2+ concentration.
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Conflict of interest statementWe declare that we have no conflict of interest.
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Mori, K. et al. (2011). Temporal Profile of the Effects of Intracisternal Injection of Magnesium Sulfate Solution on Vasodilation of Spastic Cerebral Arteries in the Canine SAH Model. In: Feng, H., Mao, Y., Zhang, J.H. (eds) Early Brain Injury or Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 110/2. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0356-2_8
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DOI: https://doi.org/10.1007/978-3-7091-0356-2_8
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