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Advances in Treatment of Cerebral Vasospasm: an Update

  • Conference paper
Early Brain Injury or Cerebral Vasospasm

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 110/1))

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Abstract

An update of published clinical advances in the treatment of cerebral vasospasm after subarachnoid haemorrhage was provided. Searching MEDLINE using the search terms “cerebral vasospasm” and “clinical trials” 46 papers were identified that had been published since the International Conference on Cerebral Vasospasm in Istanbul, Turkey in 2006. Of these 26 were either safety studies or case reports leaving 20 papers for consideration. The major topics covered were calcium antagonists, magnesium sulphate, statins, and fasudil hydrochloride. The studies published did not reach an impact justified recommended routine use, but certainly as options. Results of the CONSCIOUS trials on endothelin receptor antagonists are awaited.

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References

  1. Murray M, Dorsch NWC. Advances in vasospasm research. Acta Neurochir Suppl. 2008;104:1–4.

    Article  Google Scholar 

  2. Barth M, Thome C, Schmiedek P, Weiss C, Kasuya H, Vajkoczy P. Characterization of functional outcome and quality of life following subarachnoid hemorrhage in patients treated with and without nicardipine prolonged-release implants. J Neurosurg. 2009;110:955–60.

    Article  PubMed  Google Scholar 

  3. Conti A, Angileri FF, Longo M, Pitrone A, Granata F, La Rosa G. Intra-arterial nimodipine to treat symptomatic cerebral vasospasm following traumatic subarachnoid haemorrhage. Technical case report. Acta Neurochir (Wien). 2008;150:1197–202.

    Article  Google Scholar 

  4. Hanggi D, Beseoglu K, Turowski B, Steiger HJ. Feasibility and safety of intrathecal nimodipine on posthaemorrhagic cerebral vasospasm refractory to medical and endovascular therapy. Clin Neurol Neurosurg. 2008;110:784–90.

    Article  PubMed  Google Scholar 

  5. Mayer TE, Dichgans M, Straube A, Birnbaum T, Muller-Schunk S, Hamann GF, et al. Continuous intra-arterial nimodipine for the treatment of cerebral vasospasm. Cardiovasc Intervent Radiol. 2008;31:1200–4.

    Article  PubMed  Google Scholar 

  6. Goodson K, Lapointe M, Monroe T, Chalela JA. Intraventricular nicardipine for refractory cerebral vasospasm after subarachnoid hemorrhage. Neurocrit Care. 2008;8:247–52.

    Article  PubMed  CAS  Google Scholar 

  7. Krischek B, Kasuya H, Onda H, Hori T. Nicardipine prolonged-release implants for preventing cerebral vasospasm after subarachnoid hemorrhage: effect and outcome in the first 100 patients. Neurol Med Chir (Tokyo). 2007;47:389–94.

    Article  Google Scholar 

  8. Dorhout Mees SM, Rinkel GJ, Feigin VL, Algra A, van den Bergh WM, Vermeulen M, et al. Calcium antagonists for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2007;CD000277.

    Google Scholar 

  9. Tejada JG, Taylor RA, Ugurel MS, Hayakawa M, Lee SK, Chaloupka JC. Safety and feasibility of intra-arterial nicardipine for the treatment of subarachnoid hemorrhage-associated vasospasm: initial clinical experience with high-dose infusions. AJNR Am J Neuroradiol. 2007;28:844–8.

    PubMed  CAS  Google Scholar 

  10. Barth M, Capelle HH, Weidauer S, Weiss C, Munch E, Thome C, et al. Effect of nicardipine prolonged-release implants on cerebral vasospasm and clinical outcome after severe aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind phase IIa study. Stroke 2007;38:330–6.

    Article  PubMed  CAS  Google Scholar 

  11. Vergouwen MD, Meijers JC, Geskus RB, Coert BA, Horn J, Stroes ES, et al. Biologic effects of simvastatin in patients with aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled randomized trial. J Cereb Blood Flow Metab. 2009;29:1444–53.

    Article  PubMed  CAS  Google Scholar 

  12. Kern M, Lam MM, Knuckey NW, Lind CR. Statins may not protect against vasospasm in subarachnoid haemorrhage. J Clin Neurosci. 2009;16:527–30.

    Article  PubMed  CAS  Google Scholar 

  13. Sillberg VA, Wells GA, Perry JJ. Do statins improve outcomes and reduce the incidence of vasospasm after aneurysmal subarachnoid hemorrhage: a meta-analysis. Stroke 2008;39:2622–6.

    Article  PubMed  CAS  Google Scholar 

  14. Tseng MY, Hutchinson PJ, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ. Effects of acute pravastatin treatment on intensity of rescue therapy, length of inpatient stay, and 6-month outcome in patients after aneurysmal subarachnoid hemorrhage. Stroke 2007;38:1545–50.

    Article  PubMed  CAS  Google Scholar 

  15. Tseng MY, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ. Effects of acute treatment with statins on cerebral autoregulation in patients after aneurysmal subarachnoid hemorrhage. Neurosurg Focus. 2006;21:E10.

    Article  PubMed  Google Scholar 

  16. Mori K, Yamamoto T, Nakao Y, Osada H, Hara Y, Oyama K, et al. Initial clinical experience of vasodilatory effect of intra-cisternal infusion of magnesium sulfate for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Neurol Med Chir (Tokyo). 2009;49:139–44.

    Article  Google Scholar 

  17. Muroi C, Terzic A, Fortunati M, Yonekawa Y, Keller E. Magnesium sulfate in the management of patients with aneurysmal subarachnoid hemorrhage: a randomized, placebo-controlled, dose-adapted trial. Surg Neurol. 2008;69:33–9.

    Article  PubMed  Google Scholar 

  18. Stippler M, Crago E, Levy EI, Kerr ME, Yonas H, Horowitz MB, et al. Magnesium infusion for vasospasm prophylaxis after subarachnoid hemorrhage. J Neurosurg. 2006;105:723–9.

    Article  PubMed  CAS  Google Scholar 

  19. Schmid-Elsaesser R, Kunz M, Zausinger S, Prueckner S, Briegel J, Steiger HJ. Intravenous magnesium versus nimodipine in the treatment of patients with aneurysmal subarachnoid hemorrhage: a randomized study. Neurosurgery 2006;58:1054–65.

    Article  PubMed  Google Scholar 

  20. Wong GK, Chan MT, Boet R, Poon WS, Gin T. Intravenous magnesium sulfate after aneurysmal subarachnoid hemorrhage: a prospective randomized pilot study. J Neurosurg Anesthesiol. 2006;18:142–8.

    Article  PubMed  Google Scholar 

  21. Suzuki Y, Shibuya M, Satoh S, Sugiyama H, Seto M, Takakura K. Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study. Neurol Med Chir (Tokyo). 2008;48:241–7.

    Article  Google Scholar 

  22. Suzuki Y, Shibuya M, Satoh S, Sugimoto Y, Takakura K. A postmarketing surveillance study of fasudil treatment after aneurysmal subarachnoid hemorrhage. Surg Neurol. 2007;68:126–31.

    Article  PubMed  Google Scholar 

  23. Iwabuchi S, Yokouchi T, Hayashi M, Uehara H, Ueda M, Samejima H. Intra-arterial administration of fasudil hydrochloride for vasospasm following subarachnoid hemorrhage – analysis of time-density curve with digital subtraction angiography. Neurol Med Chir (Tokyo). 2006;46:535–9.

    Article  Google Scholar 

  24. Zhao J, Zhou D, Guo J, Ren Z, Zhou L, Wang S, et al. Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage. Neurol Med Chir (Tokyo). 2006;46:421–8.

    Article  Google Scholar 

  25. Haque R, Kellner CP, Komotar RJ, Connolly ES, Lavine SD, Solomon RA, et al. Mechanical treatment of vasospasm. Neurol Res. 2009;31:638–43.

    Article  PubMed  Google Scholar 

  26. Hanggi D, Liersch J, Turowski B, Yong M, Steiger HJ. The effect of lumboventricular lavage and simultaneous low-frequency head-motion therapy after severe subarachnoid hemorrhage: results of a single center prospective Phase II trial. J Neurosurg. 2008;108:1192–9.

    Article  PubMed  Google Scholar 

  27. Mura J, Rojas-Zalazar D, Ruiz A, Vintimilla LC, Marengo JJ. Improved outcome in high-grade aneurysmal subarachnoid hemorrhage by enhancement of endogenous clearance of cisternal blood clots: a prospective study that demonstrates the role of lamina terminalis fenestration combined with modern microsurgical cisternal blood evacuation. Minim Invasive Neurosurg. 2007;50:355–62.

    Article  PubMed  CAS  Google Scholar 

  28. Otawara Y, Ogasawara K, Kubo Y, Sasoh M, Ogawa A. Effect of continuous cisternal cerebrospinal fluid drainage for patients with thin subarachnoid hemorrhage. Vasc Health Risk Manag. 2007;3:401–4.

    PubMed  Google Scholar 

  29. Macdonald RL, Kassell NF, Mayer S, Ruefenacht D, Schmiedek P, Weidauer S, et al. Clazosentan to overcome neurological ischemia and infarction occurring after subarachnoid hemorrhage (CONSCIOUS-1): randomized, double-blind, placebo-controlled phase 2 dose-finding trial. Stroke 2008;39:3015–21.

    Article  PubMed  CAS  Google Scholar 

  30. Yoshimoto T, Shirasaka T, Fujimoto S, Yoshidumi T, Yamauchi T, Tokuda K, et al. Cilostazol may prevent cerebral vasospasm following subarachnoid hemorrhage. Neurol Med Chir (Tokyo). 2009;49:235–40.

    Article  Google Scholar 

  31. Koskinen LO, Olivecrona M, Rodling-Wahlstrom M, Naredi S. Prostacyclin treatment normalises the MCA flow velocity in nimodipine-resistant cerebral vasospasm after aneurysmal subarachnoid haemorrhage: a pilot study. Acta Neurochir (Wien). 2009;151:595–9.

    Article  Google Scholar 

  32. Tseng MY, Hutchinson PJ, Richards HK, Czosnyka M, Pickard JD, Erber WN, et al. Acute systemic erythropoietin therapy to reduce delayed ischemic deficits following aneurysmal subarachnoid hemorrhage: a Phase II randomized, double-blind, placebo-controlled trial. Clinical article. J Neurosurg. 2009;111:171–80.

    Article  PubMed  CAS  Google Scholar 

  33. Agrawal A, Patir R, Kato Y, Chopra S, Sano H, Kanno T. Role of intraventricular sodium nitroprusside in vasospasm secondary to aneurysmal subarachnoid haemorrhage: a 5-year prospective study with review of the literature. Minim Invasive Neurosurg. 2009;52:5–8.

    Article  PubMed  CAS  Google Scholar 

  34. Munakata A, Ohkuma H, Nakano T, Shimamura N, Asano K, Naraoka M. Effect of a free radical scavenger, edaravone, in the treatment of patients with aneurysmal subarachnoid hemorrhage. Neurosurgery 2009;64:423–8.

    Article  PubMed  Google Scholar 

  35. Fraticelli AT, Cholley BP, Losser MR, Saint Maurice JP, Payen D. Milrinone for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Stroke 2008;39:893–8.

    Article  PubMed  Google Scholar 

  36. Yoneda H, Shirao S, Kurokawa T, Fujisawa H, Kato S, Suzuki M. Does eicosapentaenoic acid (EPA) inhibit cerebral vasospasm in patients after aneurysmal subarachnoid hemorrhage? Acta Neurol Scand. 2008;118:54–9.

    Article  PubMed  CAS  Google Scholar 

  37. Fergusen S, Macdonald RL. Predictors of cerebral infarction in patients with aneurysmal subarachnoid hemorrhage. Neurosurgery 2007;60:658–67.

    Article  PubMed  Google Scholar 

  38. Jang YG, Ilodigwe D, Macdonald RL. Metaanalysis of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2009;10:141–7.

    Article  PubMed  CAS  Google Scholar 

  39. Hanggi D, Turowski B, Beseoglu K, Yong M, Steiger HJ. Intra-arterial nimodipine for severe cerebral vasospasm after aneurysmal subarachnoid hemorrhage: influence on clinical course and cerebral perfusion. AJNR Am J Neuroradiol. 2008;29:1053–60.

    Article  PubMed  CAS  Google Scholar 

  40. Kronvall E, Undren P, Romner B, Saveland H, Cronqvist M, Nilsson OG. Nimodipine in aneurysmal subarachnoid hemorrhage: a randomized study of intravenous or peroral administration. J Neurosurg. 2009;110:58–63.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery, University of Occupational and Environmental Health, Japan 1-1, Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan

    Takumi Sozen

  2. Department of Neurosurgery, University of Occupational and Environmental Health, Japan

    Takumi Sozen & Shigeru Nishizawa

  3. Department of Physiology, Loma Linda University of Medicine, Loma Linda, CA, 92350, USA

    Reiko Tsuchiyama, Yu Hasegawa, Hidenori Suzuki, Vikram Jadhav & John H. Zhang

  4. Department of Neurosurgery, Loma Linda University of Medicine, Loma Linda, CA, 92350, USA

    John H. Zhang

Authors
  1. Takumi Sozen
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  2. Reiko Tsuchiyama
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  3. Yu Hasegawa
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  4. Hidenori Suzuki
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  5. Vikram Jadhav
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  6. Shigeru Nishizawa
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  7. John H. Zhang
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Corresponding author

Correspondence to Takumi Sozen .

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Editors and Affiliations

  1. Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Gaotanyan 30, Chongqing, 400038, China

    H.-J. Steiger  & Hua Feng  & 

  2. Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China

    Ying Mao

  3. Departments of Physiology and Neurosurgery, Loma Linda University School of Medicine, Risley Hall, Room 223, 92354, Loma Linda, California, USA

    John H. Zhang

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Sozen, T. et al. (2011). Advances in Treatment of Cerebral Vasospasm: an Update. In: Feng, H., Mao, Y., Zhang, J.H. (eds) Early Brain Injury or Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 110/1. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0353-1_4

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  • DOI: https://doi.org/10.1007/978-3-7091-0353-1_4

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-0352-4

  • Online ISBN: 978-3-7091-0353-1

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