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A Darwinian-Evolutionary Concept for Atherogenesis: The Role of Immunity to HSP60

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Book cover Inflammation and Atherosclerosis

Abstract

Studying the mechanisms operative in the very earliest stage of a given disease is a difficult, and often even impossible task in the human situation. At this stage, clinical symptoms are not yet manifest and the patients-to-be have not yet consulted a physician. Experiments and analyses even before microscopically or biochemically sizable pathologic hallmarks emerge can therefore only be carried out in animal models. When such animal models are developed they can then allow for a chronological monitoring of pathogenetic events from morphologically and clinically unapparent to fully blown, often lethal stages of the disease under study.

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Authors and Affiliations

  1. Laboratory of Autoimmunity, Division for Experimental Pathology and Immunology, Biocenter, Innsbruck Medical University, Peter-Mayr-Strasse 4a, A-6020, Innsbruck, Austria

    Georg Wick, Nicole Buhr & Cecilia Grundtman

  2. Department of Vascular Surgery, Innsbruck Medical University, Anichstrasse 35, A-6020, Innsbruck, Austria

    Gustav Fraedrich

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  1. Georg Wick
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  2. Nicole Buhr
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  3. Gustav Fraedrich
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  4. Cecilia Grundtman
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Correspondence to Georg Wick .

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  1. Medical University Innsbruck, Peter-Mayr-Strasse 4 a, Innsbruck, 6020, Austria

    Georg Wick

  2. Laboratory of Autoimmunity, Division of Experimental Pathophysiology, Biocenter, Innsbruck Medical University, Schöpfstraße 41, Innsbruck, 6020, Austria

    Cecilia Grundtman

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Wick, G., Buhr, N., Fraedrich, G., Grundtman, C. (2012). A Darwinian-Evolutionary Concept for Atherogenesis: The Role of Immunity to HSP60. In: Wick, G., Grundtman, C. (eds) Inflammation and Atherosclerosis. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0338-8_9

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