Abstract
Theophylline is frequently used in patients with acute or chronic reversible airway disease. Its analysis in serum or plasma is required both for pharmacological studies and the individual control of drug therapy. Therapeutic drug monitoring is necessary because of wide individual variation of the liver capacity to metabolize the drug under various physiologic or pathologic circumstances. Five basic methods are recommended for the analysis of theophylline in serum or plasma, most of them in many variants:
-
1.
Extraction and UV-spectrophotometry (UV) [6, 18, 19]
-
2.
Radioimmunoassay (RIA) [2, 11)
-
3.
High pressure liquid chromatography (HPLC) [3, 10, 13, 14, 22, 23, 24]
-
4.
Homogeneous enzymeimmunoassay (EIA, EMIT®) [4, 5, 8, 12]
-
5.
Gaschromatography (GC) [7, 9, 15, 16, 20, 21]
We evaluated the methods 1–4 with regard to analytical reliability, reagent cost and practicability.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Averdunk, R., Borner, K.: Z. Kin. Chem. Klin. Biochem. 8, 263–268 (1970)
Cook, C. E., Twine, M. E., Myers, M., Amerson, E., Kepler, J. A., Tegler, G. F.: Res. Comm. Chem. Path. Pharm. 13, 497–505 (1976)
Evenson, M. A., Warren, B. L.: Clin. Chem. 22, 851–855 (1976)
Gushaw, J. B., HU, M. W., Singh, P., Miller, J. G., Schneider, R. S.: Clin. Chem. 23, 1144 (1977)
Ishizaki, T., Watanabe, M., Morishita, N.: Br. J. Clin. Pharmac. 7, 333–341 (1979)
Jatlow, P.: Clin. Chem. 21, 1518–1520 (1975)
Johnson, G. F., Dechtiaruk, W. A., Solomon, H. M.: Clin. Chem. 21, 144–147 (1975)
Koup, J. R., Brodsky, B.: Amer. Rev. Resp. Dis. 117, 1135–1138 (1978)
Least, C. J., Johnson, G. F., Solomon, H. M.: Clin. Chem. 22, 765–768 (1976)
Manion, C. V., Shoeman, D. W., Azarnoff, D. L.: J. Chromatogr. 101, 169–174 (1974)
Neese, A. L., Soyka, L. F.: Clin. Pharmacol. Ther. 21, 631–641 (1977)
Oellerich, M., Sybrecht, G. W., Haeckel, R.: J. Clin. Chem. Clin. Biochem. 17, 299–302 (1979)
Orcut, J. J., Kozak, P. P., Gillman, Sh. A., Cummins, L. H.: Clin. Chem. 23, 599–601 (1977)
Peng, G. W., Gadallah, M. A. F., Chiou, W. T.: Clin. Chem. 24, 357–360 (1978)
Perrier, D., Lear, E.: Clin. Chem. 22, 898–900 (1976)
Reid, R., Fareed, J., Bermes, E. W., Ivery, D., Messmore, H.: Clin. Chem. 22, 1166 (1976)
Sachs, L.: Angewandte Statistik. Springer-Verlag, Berlin, 1974
Schack, J. A., Waxier, S. H.: J. Pharmacol. Exper. Ther. 97, 283–291 (1949)
Schwerdtner, H. A., Wallace, J. E., Blum, K.: Clin. Chem. 24, 360–361 (1978)
Schwerdtner, H. A., Ludden, T. M., Wallace, J. E.: Clin. Chem. 22, 1167 (1976)
Sheehan, M., Hertel, R. H., Kelly, Ch. T.: Clin. Chem. 23, 64–68 (1977)
Sitar, D. S., Piafsky, K. M., Ragno, R. E., Ogilvie, R. I.: Clin. Chem. 21, 1774–1776 (1975)
Thompson, J. D., Nagasawa, H. T., Jenne, J. W.: J. Lab. Clin. Med. 84, 584–593 (1974)
Weinberger, M., Chidsey, Ch.: Clin. Chem. 21, 834–837 (1975)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Springer Fachmedien Wiesbaden
About this chapter
Cite this chapter
Borner, K., Staib, A.H., Schuppan, D., Molz, K.H., Lissner, R., Lichey, J. (1980). Analytical reliability of methods to determine theophylline in serum or plasma. In: Rietbrock, N., Woodcock, B.G., Neuhaus, G. (eds) Methods in Clinical Pharmacology. Methods in clinical pharmacology, vol 1. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-14027-6_37
Download citation
DOI: https://doi.org/10.1007/978-3-663-14027-6_37
Publisher Name: Vieweg+Teubner Verlag, Wiesbaden
Print ISBN: 978-3-528-07902-4
Online ISBN: 978-3-663-14027-6
eBook Packages: Springer Book Archive