Abstract
Epidemiological studies show that inhalation of cigarette smoke is a risk factor in cardiovascular disease (CVD) (The Health Consequences of Smoking, 1975). It is generally accepted that CVD is mainly caused by arteriosclerosis (AS) of the coronary vessels. Cigarette smoke consists of a mixture of several hundred compounds and theoretically every one of them may have an influence on the development of AS. To consider the question which compound in tobacco smoke is responsible for the action as a risk factor the most pharmacological active compounds have to be investigated. We can assume that AS needs a relatively long time to develop, and is a result of disturbed fat metabolism, so only long time effects of tobacco smoke components have to be considered.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Astrup, P. (1976): Studies on carbon monoxide and nicotine. In “Proc. 3rd World Conference on Smoking and Health, Vol. I. Modifying the Risk for the Smoker” (E. L. Wynder, D. Hoffmann, G. B. Gori, eds.), pp. 331–341, U.S. Govt. Printing Office, Washington, D.C.
Astrup, P., Kjeldsen, K., and Wanstrup, J. (1966): Enhancing influence of carbon monoxide on the development of atheromatosis in cholesterol-fed rabbits. J. Atheroscler. Res. 7, 343–354.
Gainer, J. L., and Chisolm, C. M. (1974): Oxygen diffusion and atherosclerosis. Atherosclerosis 19, 135–138.
Gudbjarnason, S. (1968): The effect of chronic nicotine administration on cholesterol metabolism of liver, serum, heart and brain. J. Pharmacol. exper. Thera p. 161, 47–54.
Hjermann, I., Helgeland, A., Holme, I., Lund-Larsen, P. G., and Leren, P. (1976): The intercorrelation of serum cholesterol, cigarette smoking and body weight. Acta Med. Scand. 200, 479–485.
Kjeldsen, K. (1969): Smoking and atherosclerosis. Munksgaard, Copenhagen.
Schievelbein, H., Londong; V., Londong, W., Grumbach, H., and Remplik, V. (1970): Nicotine and arteriosclerosis. An experimental contribution to the influence of nicotine on fat metabolism. Z. klirr. Chem. u. klirr. Biochem. 8, 190–196.
Schröder, J. (1968): Kohlenmonoxydgehalt des Blutes bei Rauchern. In “Nikotin-Pharmakologie und Toxikologie des Tabakrauches” (H. Schievelbein, ed.), pp. 278–284, G. Thieme-Verlag, Stuttgart.
The health consequences of smoking (1975): U.S. Department of Health, Education, and Welfare, Atlanta, Georgia, USA.
Timm, J. (1974): Trendanalysen zum Problem des Verbrauches an Nikotin und Rauchkondensat in der Bundesrepublik Deutschland für die Jahre 1961 bis 1972. Beiträge zur Tabakforschung 7, 206–211.
Wenzel, D. G., and Beckloff, G. L. (1958): The effect of nicotine on experimental hypercholesterolemia in the rabbit. J. Amer. pharm. Assoc. 47, 338–343.
Westfall, T. C., and Watts, D. T. (1964): Catecholamine excretion in smokers and nonsmokers. J. Appl. Physiol. 19, 40–42.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1978 Springer Fachmedien Wiesbaden
About this chapter
Cite this chapter
Schievelbein, H., Heinemann, G. (1978). Tobacco Smoke as a Risk Factor in the Etiology of Arteriosclerosis. In: International Symposium State of Prevention and Therapy in Human Arteriosclerosis and in Animal Models. Abhandlungen der Rheinisch-Westfälischen Akademie der Wissenschaften. VS Verlag für Sozialwissenschaften, Wiesbaden. https://doi.org/10.1007/978-3-663-06754-2_47
Download citation
DOI: https://doi.org/10.1007/978-3-663-06754-2_47
Publisher Name: VS Verlag für Sozialwissenschaften, Wiesbaden
Print ISBN: 978-3-531-05077-5
Online ISBN: 978-3-663-06754-2
eBook Packages: Springer Book Archive