Summary
Concentrations of theophylline in plasma und saliva of 84 chronic asthmatic children were determined by means of high-performance liquid chromatography. The dose of theophylline (given as dragee) varied between 12 and 28 mg/kg/die. Plasma/saliva ratios of theophylline ranged from 0.43 to 3.05 (mean value 1.39). In 16 patients measurements of theophylline in plasma and saliva were repeated. The correlation between the first and second determination of the theophylline plasma/saliva ratio was rather low (r = 0.66). Although the variation of plasma/ saliva ratios is high, the determination of theophylline levels in saliva seems to be a helpful tool to monitor the initial theophylline therapy: When a saliva concentration of 7 mg/1 theophylline was reached, 86 % of the patients were within the therapeutic range of theophylline (10–20 mg/1) in plasma. Consequently a determination of theophylline in plasma seems to be useful, if theophylline levels in saliva are above 7 mg/l. Therefore venous puncture, which is more reliable for the establishment of precise dosis regimens for theophylline, needs to be performed less frequently when premeasurements on saliva are carried out. The main goal is to standardize the collecting procedure for saliva samples so as to improve their usefulness in the prediction of serum theophylline levels.
Mit Unterstützung der Stiftung Volkswagenwerk
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Ellis, E. F., Koysooko, R., Levy, G.: Pharmacokinetics of theophylline in children with asthma. Pediatrics 58, 542–547 (1976).
Ahrens, J.: Theophylline blood levels with theophylline ethylene diamine. Pneumonologie Supp. 00, 275–277 (1976).
Ginchansky, E., Weinberger, M.: Relationship of theophylline clearance to oral dosage in children with chronic asthma. J. Pediatr. 91, 655–660 (1977).
Sarrazin, E., Hendeles, L., Weinberger, M., Muir, K., Riegelman, S.: Dose dependent kinetics for theophylline: observations among ambulatory asthmatic children. J. Pediatr. 97, 825–828 (1980).
Weinberger, M., Hendeles, L., Ahrens, R.: Clinical pharmacology of drugs used for asthma. Pediat. Clin. N. Am. 28, 47–135 (1981).
Wemhöner, S., Oellerich, M., Sybrecht, G.: Optimierung der Therapie mit Theophyllin-Präparaten bei obstruktiven Ventilationsstörungen. 1. Bioverfügbarkeit und Pharmakokinetik verschiedener Theophyllin-Präparate. Prax. Pneumol. 35, 36–41 (1981).
Wemhöner, S., Oellerich, M, Sybrecht, G.: Optimierung der Therapie mit Theophyllin-Präparaten bei obstruktiven Ventilationsstörungen. 2. Anwendung von Theophyllin-retard-Präparaten in der Dauertherapie bei Nichtrauchern mit und ohne Herzinsuffizienz. Prax. Pneumol. 35, 42–46 (1981).
Galant, S. P., Gillman, S. A., Camumins, L. H., Kozak, P. P., Orcutt, J. J.: Reliability of salivary theophylline as a guide to plasma theophylline levels. Am. J. Dis. Child. 131, 970–972 (1977).
Danhof, M., Breimer, D. D.: Therapeutic drug monitoring in saliva. Clinical Pharmacokinetics 3, 39–57 (1978).
Jenne, J. W., Wyze, E., Rood, F. S., MacDonald, F. M.: Pharmacokinetics of theophylline. Application to adjustment of the clinical dose of aminophylline. Clin. Pharmacol. Ther. 13, 349–360 (1972).
Weinberger, M., Bronsky, E. A.: Evaluation of oral bronchodilator therapy in asthmatic children. J. Pediat. 84, 421–427 (1974).
Pollock, J., Kiechel, F., Cooper, D., Weinberger, M.: Relationship of serum theophylline concentration to inhibition of exercise-induced bronchospasm and comparison with cromolyn. Pediatrics 60, 840–844 (1977).
Boobis, S., Trembath, P. W.: Plasma-saliva ratio of theophylline following oral theophylline derivatives. Brit. J. Clin. Pharmacol. 6, 456–457 (1978).
Nicholson, D. P., Chick, T. W.: A re-evaluation of parenteral aminophylline. Am. Rev. Resp. Dis. 108, 241–247 (1973).
Koysooko, R., Ellis, E. F., Levy, G.: Relationship between theophylline concentration in plasma and saliva of man. Clin. Pharmacol. Ther. 15, 454–460 (1974).
De Blaey, C. J., de Boer, A. G.: Kwaliteitsbeheersing van aminofyllinezetpillen. Pharm. Weekbl. 111, 1216–1221 (1976).
Eney, R. D., Goldstein, E. O.: Compliance of chronic asthmatics with oral administration or theophylline as measured by serum and salivary levels. Pediatrics 57, 513–517 (1976).
Hendeles, L., Burkey, S., Bighley, L., Richardson, R.: Unpredictability of theophylline saliva measurements in chronic obstructive pulmonary disease. J. Allergy Clin. Immunol. 60, 335–338 (1977).
Gillmann, S. A., Galant, S. P., Cummins, L. H., Kozak, P. O., Groncy, C., Orcutt, J. J.: Reliability of salivary theophylline as a guide to plasma theophylline levels. Ann. Allergy 38, 439 (1977).
Levy, G., Ellis, E. F., Koysooko, R.: Indirect plasma-theophylline monitoring in asthmatic children by determination of theophylline concentration in saliva. Pediatrics 53, 873 (1974).
Johnson, G.F., Dechtiaruk, W. A., Solomon, H. M.: Gas-chromatographic determination of theophylline in human serum and saliva. Clin. Chem. 21, 144–147 (1975).
Knop, H. J., Kalafusz, R., Knols, A. J. F., van der Kleijn, E.: Preliminary report on the saliva/ plasma ratio of theophylline after administration of theophylline derivatives in suppositories. Pharm. Weekl. 110, 1297–1299 (1975).
Hendeles, L., Weinberger, M., Johnson, G.: Monitoring serum theophylline levels. Clinical Pharmacokinetics 3, 294–312 (1978).
Rylance, G. W., Moreland, T. A.: Drug level monitoring in paediatric practice. Arch Dis. Childh. 55, 89–98 (1980).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH, Braunschweig
About this chapter
Cite this chapter
Lindemann, H., Schwandt, HJ. (1982). Zur Überwachung der Theophyllin-Therapie über die Saliva-Konzentration bei Kindern mit Asthma bronchiale. In: Rietbrock, N., Woodcock, B.G., Staib, A.H. (eds) Theophylline and other Methylxanthines / Theophyllin und andere Methylxanthine. Methods in Clinical Pharmacology, vol 3. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-05268-5_33
Download citation
DOI: https://doi.org/10.1007/978-3-663-05268-5_33
Publisher Name: Vieweg+Teubner Verlag, Wiesbaden
Print ISBN: 978-3-663-05269-2
Online ISBN: 978-3-663-05268-5
eBook Packages: Springer Book Archive