Abstract
Immunological processes mediated by cytokines are assumed to play an important role in atherogenesis. Besides monocytes, endothelial cells and T-cells, also vascular smooth muscle cells (SMC) are able to synthezise and release various cytokines and growth factors. IL-6, an important T-cell differentiation factor, is quantitatively one of the main secretory products of SMC and can be secreted in large amounts in response to IL-1 and other growth factors.
Zusammenfassung
I mmunologischen, zytokinvermittelten Prozessen wird eine wichtige Rolle bei der Atherogenese zugeordnet. Neben Makrophagen, Endothelzellen und T-Lymphozyten sind auch glatte Gefäßmuskelzellen in der Lage, zahlreiche Zytokine und Wachstumsfaktoren zu synthetisieren und freizusetzen. Interleukin 6 (IL-6), ein bedeutsamer Differenzierungsfaktor für T-Lymphozyten, gehört zu den quantitativ am häufigsten von glatten Gefäßmuskelzellen sezernierten Interleukinen und wird insbesondere nach Stimulation mit IL-1 und anderen Wachstumsfaktoren freigesetzt.
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© 1993 Springer Fachmedien Wiesbaden
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Hautmann, M., von Hodenberg, E., Hebbecker, C., Pestel, E., Kübler, W., Thiery, J. (1993). Release of interleukin-6 (IL-6) from human vascular smooth muscle cells. In: Heinle, H., Schulte, H., Schaefer, H.E. (eds) Diätetik und Arteriosklerose. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-01942-8_61
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DOI: https://doi.org/10.1007/978-3-663-01942-8_61
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