Skip to main content

Entwicklungspsychopharmakologie

  • Chapter
  • First Online:
Neuro-/Psychopharmaka im Kindes- und Jugendalter

Zusammenfassung

Die Entwicklungspsychopharmakologie umfasst alle Fragestellungen der Anwendung von Neuro‑/Psychopharmaka einschließlich der Arzneimittelsicherheit und der Rahmenbedingungen bei einer medikamentösen Behandlung im Kindes- und Jugendalter. In diesem Kapitel werden die Einflüsse der alters- und geschlechtsabhängigen körperlichen und geistigen Reifung auf die Wirkung von Neuro‑/ Psychopharmaka besprochen, und das therapeutische Drug-Monitoring zur Optimierung des Therapieeffektes und als proaktives Instrument zur Förderung der Pharmakovigilanz wird erläutert.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 149.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Aichhorn W, Marksteiner J, Walch T et al. (2007) Age and gender effects of olanzapine and risperidone plasma concentrations in children and adolescents. J Child Adol Psychopharm 17:665–673

    Article  Google Scholar 

  • Andersen SL (2005) Stimulants and the developing brain. Trends Pharmcol Sci 26:237–243

    Article  CAS  Google Scholar 

  • Bai Y, Liu T, Xu A, Yang H, Gao K (2019) Comparison of common side effects from mood stabilizers and antipsychotics between pediatric and adult patients with bipolar disorder: a systematic review of randomized, double-blind, placebo-controlled trials. Exp Opin Drug Saf 18:703–717

    Article  Google Scholar 

  • Correll CU, Carlson HE (2006) Endocrine and metabolic adverse effects of psychotropic medications in children and adolescents. J Am Acad Child Adolesc Psychiatry 45:771–791

    Article  PubMed  Google Scholar 

  • De Hert M, Dobbelaere M, Sheridan EM et al. (2011) Metabolic and endocrine adverse effects of second generation antipsychotics in children and adolescents: a systematic review of randomized, placebo controlled trials and guidelines for clinical practice. Eur Psychiatry 26:144–158

    Article  PubMed  Google Scholar 

  • Dragioti E, Solmi M, Favaro A et al. (2019) Association of antidepressant use with adverse health outcomes: a systematic umbrella review. JAMA Psychiatry 76:1241–1255

    Article  PubMed  PubMed Central  Google Scholar 

  • Duijnhoven RG, Straus SM, Raine JM et al. (2013) Number of patients studied prior to approval of new medicines: a database analysis. PLoS Med 10(3):e1001407

    Article  PubMed  PubMed Central  Google Scholar 

  • Egberts K, Mehler-Wex C, Gerlach M (2011) Therapeutic drug monitoring in child and adolescent psychiatry. Pharmacopsychiatry 44:249–253

    Article  CAS  PubMed  Google Scholar 

  • Egberts K, Karwautz A, Plener PL et al. (2015) Pharmakovigilanz in der Kinder- und Jugendpsychiatrie. Z Kinder Jugendpsychiatr 43:21–28

    Article  Google Scholar 

  • Egberts K, Plener P, Malzhan U et al. (2020) Sicherheit von Psychopharmaka bei Kindern und Jugendlichen in der klinischen Praxis – Erkenntnisse einer prospektiven Studie. Bull Arzneimittelsicherh 3:4–10

    Google Scholar 

  • Egberts K, Fekete S, Taurines R et al. (2022a) Therapeutisches Drug Monitoring zur Optimierung der Psychopharmakotherapie von Kindern und Jugendlichen – Update und Leitfaden für die Praxis. Z Kinder Jugendpsychiatrie 50:133. https://doi.org/10.1024/1422-4917/a000845

    Article  Google Scholar 

  • Egberts K, Gerlach M, Correl C et al. (2022b) Serious adverse drug reactions in children and adolescents treated on- and off-label with antidepressants and antipsychotics in clinical practice. Pharmacopsychiatry 55:255. https://doi.org/10.1055/a-1716-1856

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fedorow H, Halliday GM, Rickert CH et al. (2006) Evidence for specific phases in the development of human neuromelanin. Neurobiol Aging 27:506–512

    Article  CAS  PubMed  Google Scholar 

  • Findling RL, Kauffman RE, Sallee FR et al. (2008) Tolerability and pharmacokinetics of aripiprazole in children and adolescents with psychiatric disorders. An open-label, dose-escalation study. J Clin Psychopharmacol 28:441–446

    Article  CAS  PubMed  Google Scholar 

  • Findling RL, Kauffman R, Sallee FR et al. (2009) An open-label study of aripiprazole. Pharmacokinetics, tolerability, and effectiveness in children and adolescents with conduct disorder. J Child Adolesc Psychopharmacol 19:431–439

    Article  PubMed  Google Scholar 

  • Fornaro M, Anastasia A, Valchera A et al. (2019) The FDA „Black Box“ warning on antidepressant suicide risk in young adults: more harm than benefits? Front Psychiatry 10:294

    Article  PubMed  PubMed Central  Google Scholar 

  • Franke C, Fegert JM, Krüger U, Kölch M (2016) Verordnungshäufigkeiten von Psychopharmaka bei Kindern und Jugendlichen mit psychischen Erkrankungen in Deutschland. Z Kinder Jugendpsychiatr Psychother 44:259–274

    Article  PubMed  Google Scholar 

  • Gerlach M, Wewetzer C (2008) Entwicklungspsychopharmakologie. In: Herpertz-Dahlmann B, Resch F, Schulte-Markwort M, Warnke A (Hrsg) Entwicklungspsychiatrie. Biopsychologische Grundlagen und die Entwicklung psychischer Störungen, 2. Aufl. Schattauer, Stuttgart, S 372–407

    Google Scholar 

  • Gerlach M, Warnke A (2016) Editorial. Medikamentöse Behandlung in der Kinder- und Jugendpsychiatrie in Deutschland zwischen ethischen, sozial- und haftungsrechtlichen Konflikten. Z Kinder Jugendpsychiatr Psychother 44:249–255

    Article  PubMed  Google Scholar 

  • Gerlach M, Egberts K, Dang S-Y et al. (2016) Therapeutic drug monitoring as a measure of proactive pharmacovigilance in child and adolescent psychiatry. Exp Opin Drug Saf 15:1477–1482

    Article  CAS  Google Scholar 

  • Gerlach M, Renner T, Romanos M (2023) Besonderheiten und Probleme der Psychopharmakologie im Kindes- und Jugendalter. Bundesgesundheitsblatt https://doi.org/10.1007/s00103-023-03718-z

  • Giedd JN, Vaituzis C, Hamburger SD et al. (1996) Quantitative MRI of the temporale lobe, amgydala, and hippocampus in normal human development: Ages 4–18 years. J Comp Neurol 366:223–230

    Article  CAS  PubMed  Google Scholar 

  • Giedd JN, Blumenthal J, Jeffries NO et al. (1999) Brain development during childhood and adolescence: a longitudenal MRI study. Nat Neurosci 2:861–863

    Article  CAS  PubMed  Google Scholar 

  • Häge A, Weymann L, Bliznak L et al. (2018) Non-adherence to psychotropic medication among adolescents – A systematic review of the literature. Z Kinder Jugendpsychiatr Psychother 46:69–78

    Article  PubMed  Google Scholar 

  • Hiemke C, Bergemann N, Clement HW et al. (2018) Consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology – Update 2017. Pharmacopsychiatry 51:9–62

    Article  CAS  PubMed  Google Scholar 

  • Huttenlocher PR (1990) Morphometric study of human cerebral cortex development. Neuropsychologia 28:517–527

    Article  CAS  PubMed  Google Scholar 

  • Karwautz A, Bangratz S, Huemer J (2011) Qualitätssicherung in der kinder- und jugendpsychiatrischen Psychopharmakotherapie – Einsatz von Therapeutic Drug Monitoring. Paediatr Paedolog 2:10–12

    Article  Google Scholar 

  • Kearns GL, Abdel-Rahman SM, Alander SW et al. (2003) Developmental pharmacology – drug disposition, action, and therapy in infants and children. N Engl J Med 349:1157–1167

    Article  CAS  PubMed  Google Scholar 

  • Kloosterboer SM, Vierhout D, Stojanova J et al. (2020) Psychotropic drug concentrations and clinical outcomes in children and adolescents: a systematic review. Exp Opin Drug Saf. https://doi.org/10.1080/14740338.2020.1770224

    Article  Google Scholar 

  • Konradi Ch, Kornhuber J, Sofic E et al. (1992) Variations of monoamines and their metabolites in the human putamen. Brain Res 579:285–290

    Article  CAS  PubMed  Google Scholar 

  • Kornhuber J, Konradi Ch, Mack-Burkhardt F et al. (1989) Ontogenesis of monoamine oxidase-A and -B in the human brain frontal cortex. Brain Res 499:81–86

    Article  CAS  PubMed  Google Scholar 

  • Kryzhanovskaya LA, Xu W, Millen BA et al. (2012) Comparison of long-term (at least 24 weeks) weight gain and metabolic changes between adolescents and adults treated with olanzapine. J Child Adolesc Psychopharmacol 22:157–165

    Article  CAS  PubMed  Google Scholar 

  • Lasser KE, Allen PD, Woolhandler SJ et al. (2002) Timing of new black box warnings and withdrawals for prescription medications. JAMA 287:2215–2220

    Article  PubMed  Google Scholar 

  • Lehmkuhl G, Schubert I (2014) Psychotropic medication in children and adolescents. Dtsch Arztebl Int 111:23–24

    PubMed  PubMed Central  Google Scholar 

  • Morselli PL, Cuche H, Zarifian E (1978) Pharmacokinetics of psychotropic drugs in the pediatric patient. In: Mendlewicz J, van Praag HM (Hrsg) Childhood psychopharmacology: Current concepts. Advances in Biological Psychiatry. Karger, Basel, S 70–86

    Google Scholar 

  • Patel MX, Bowskill S, Couchman L et al. (2011) Plasma olanzapine in relation to prescribed dose and other factors. Data from a therapeutic drug monitoring service, 1999–2009. J Clin Psychopharmacol 31:411–417

    Article  CAS  PubMed  Google Scholar 

  • Paulzen M, Liebe C, Gründer G (2021) Labormonitoring vor und während Psychopharmakotherapie – Schritt für Schritt. PSYCHup2date 15:187–196

    Google Scholar 

  • Smogur M, Onesanu A, Plessen KJ, Eap CB, Anermot N (2022) Psychotropic drug prescription in children and adolescents: approved medications in European countries and the United States. J Child Adol Psychopharmacol. https://doi.org/10.1089/cap.2021.0027

    Article  Google Scholar 

  • Retz W, Kornhuber J, Riederer P (1996) Neurotransmission and the ontology of human brain. J Neural Transm 103:403–419

    Article  CAS  PubMed  Google Scholar 

  • Rivera-Calimlin L, Griesbach PH, Perlmutter R (1979) Plasma chlorpromazine concentrations in children with behavioral disorders and mental illness. Clin Pharmacol Ther 26:114–121

    Article  Google Scholar 

  • Rogers AS (1994) A research agenda for the study of therapeutic agents in adolescents. J Adolesc Health 15:672–678

    Article  CAS  PubMed  Google Scholar 

  • Sammons HM, Gray C, Hudson H, Cherrill J, Choonara I (2008) Safety in paediatric clinical trial – a 7-year review. Acta Paediatr 97:474–477

    Article  CAS  PubMed  Google Scholar 

  • Seeman P, Bzowej NH, Guan H-C et al. (1987) Human-brain dopamine-receptors in children and aging adults. Synapse 1:399–404

    Article  CAS  PubMed  Google Scholar 

  • Taurines R, Burger R, Wewetzer Ch et al. (2013) The relation between dosage, serum concentrations and clinical outcome in children and adolescents treated with sertraline: a naturalistic study. Ther Drug Monit 35:84–91

    Article  CAS  PubMed  Google Scholar 

  • Tini E, Smigielski L, Romanos M et al. (2021) Therapeutic drug monitoring of sertraline in children and adolescents: a naturalistic study with insights into the clinical response and treatment of obsessive-compulsive disorder. Compreh Psychiatry. https://doi.org/10.1016/j.comppsych.2022.152301

    Article  Google Scholar 

  • Thompson PM, Gieddi JN, Woods RP et al. (2000) Growth patterns in the developing brain detected by using continuum mechanical tensor maps. Nature 404:190–193

    Article  CAS  PubMed  Google Scholar 

  • Zito JM, Derivan AT, Kratochvil C et al. (2008) Off-label psychopharmacologic prescribing for children: history supports close clinical monitoring. Child Adolesc Psychiatry Ment Health 2:24

    Article  PubMed  PubMed Central  Google Scholar 

Quellen und weiterführende Literatur

  • Egberts K, Fekete S, Häge A et al. (2022) Therapeutisches Drug Monitoring in der Kinder- und Jugendpsychiatrie – Update und Leitfaden für die Praxis. Z Kinder-jugendpsychiatr Psychother. https://doi.org/10.1024/1422-4917/a000845

    Article  Google Scholar 

  • Gerlach M, Egberts K, Dang S-Y et al. (2016) Therapeutic drug monitoring as a measure of proactive pharmacovigilance in child and adolescent psychiatry. Exp Opin Drug Saf 15:1477–1482

    Article  CAS  Google Scholar 

  • Hiemke C, Bergemann N, Clement HW et al. (2018) Consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology – Update 2017. Pharmacopsychiatry 51:9–62

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Manfred Gerlach .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 Der/die Autor(en), exklusiv lizenziert an Springer-Verlag GmbH, DE, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Gerlach, M., Egberts, K., Taurines, R., Mehler-Wex, C. (2023). Entwicklungspsychopharmakologie. In: Gerlach, M., Mehler-Wex, C., Romanos, M., Walitza, S., Wewetzer, C. (eds) Neuro-/Psychopharmaka im Kindes- und Jugendalter. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-65267-1_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-65267-1_2

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-65266-4

  • Online ISBN: 978-3-662-65267-1

  • eBook Packages: Psychology (German Language)

Publish with us

Policies and ethics