Abstract
In recent years, a steadily growing number of investigations has led to rapid progress in the understanding of the neurobiological basis of posttraumatic stress disorder (PTSD). Apart from the impressive clinical picture, the fascination that this disease holds for neurobiologically oriented researchers is certainly largely due to the fact that stress research and research into the neural, molecular-biological and pharmacological foundations of psychopathology complement and cross-fertilise each other. This is particularly evident in the areas of the influence of stress on learning and memory processes as well as in the field of emotion regulation. In this chapter, this interaction and its significance for the understanding of the disease and the therapy of PTSD will be illustrated with a few examples.
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Literature
Adamec, R. E., & Shallow, T. (1993). Lasting effects on rodent anxiety of a single exposure to a cat. Physiology and Behaviour, 54, 101–109.
Aerni, A., Traber, R., Hock, C., Roozendaal, B., Schelling, G., Papassotiropoulos, A., Nitsch, R. M., Schnyder, U., & de Quervain, D. J. F. (2004). Low-dose kortisol for symptoms of posttraumatic stress disorder. American Journal of Psychiatry, 161, 1488–1490.
Aisa, B., Tordera, R., Lasheras, B., Del Rio, J., & Ramirez, M. J. (2007). Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats. Psychoneuroendocrinology, 32, 256–266.
Andersen, S. L., et al. (2008). Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development. The Journal of Neuropsychiatry and Clinical Neurosciences, 20(3), 292–301.
Arborelius, L., Owens, M. J., Plotsky, P. M., & Nemeroff, C. B. (1999). The role of corticotropin-releasing factor in depression and anxiety disorders. Journal of Endocrinology, 160, 1–12.
Armony, J. L., Corbo, V., Clement, M. H., & Brunet, A. (2005). Amygdala response in patients with acute PTSD to masked and unmasked emotional facial expressions. American Journal of Psychiatry, 162, 1961–1963.
Asmundson, G. J., Coons, M. J., Taylor, S., & Katz, J. (2002). PTSD and the experience of pain: Research and clinical implications of shared vulnerability and mutual maintenance models. Canadian Journal of Psychiatry, 47, 930–937.
Badour, C. L., Bown, S., Adams, T. G., Bunaciu, L., & Feldner, M. T. (2012). Specificity of fear and disgust experienced during traumatic interpersonal victimization in predicting posttraumatic stress and contamination-based obsessive-compulsive symptoms. Journal of Anxiety Disorders, 26, 590–598.
Baker, D. B., West, S. A., Nicholson, W. E., Ekhator, N. N., Kasckow, J. W., Hill, K. K., Bruce, A. B., Orth, D. N., & Geracioti, T. D. (1999). Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder. American Journal of Psychiatry, 156, 585–588.
Barad, M., Gean, P. W., & Lutz, B. (2006). The role of the amygdala in the extinction of conditioned fear. Biological Psychiatry, 60, 322–328.
Bohus, M., Landwehrmeyer, G. B., Stiglmayr, C. E., Limberger, M. F., Boehme, R., & Schmahl, C. G. (1999). Naltrexone in the treatment of dissociative symptoms in patients with borderline personality disorder: An open-label trial. Journal of Clinical Psychiatry, 60, 598–603.
Bremner, J. D. (2002). Does stress damage the brain? Understanding trauma-related disorders from a mind-body perspective. Norton.
Bremner, J. D. (2003). Functional neuroanatomical correlates of traumatic stress revisited 7 years later, this time with data. Psychopharmacology Bulletin, 37, 6–25.
Bremner, J. D., Licinio, J., Darnell, A., Krystal, J. H., Owens, M., Southwick, S. M., Nemeroff, C. B., & Charney, D. S. (1997). Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. American Journal of Psychiatry, 154, 624–629.
Bremner, J. D., Mletzko, T., Welter, S., Siddiq, S., Reed, L., Williams, C., Heim, C. M., & Nemeroff, C. B. (2004). Treatment of posttraumatic stress disorder with phenytoin: An open label pilot study. Journal of Clinical Psychiatry, 65, 1559–1564.
Bremner, J. D., Randall, P., Scott, T. M., Bronen, R. A., Seibly, J. P., Southwick, S. M., Delaney, R. C., McCarthy, G., Charney, D. S., & Innis, R. B. (1995). MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. American Journal of Psychiatry, 154, 973–981.
Bremner, J. D., Mletzko, T., Welter, S., Quinn, S., Williams, C., Brummer, M., Siddiq, S., Reed, L., Heim, C. M., & Nemeroff, C. B. (2005a). Effects of phenytoin on memory, cognition and brain structure in posttraumatic stress disorder: A pilot study. Journal of Psychopharmacology, 19, 159–165.
Bremner, J. D., Vermetten, E., Schmahl, C., Vaccarino, L. V., Vythilingam, M., Afzal, N., Grillon, C., & Charney, D. S. (2005b). Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual abuse-related posttraumatic stress disorder. Psychological Medicine, 35, 791–806.
Bremner, J. D., Vythilingam, M., Vermetten, E., Adil, J., Khan, S., Nazeer, A., Afzal, N., McGlashan, T., Anderson, G., Heninger, G. R., Southwick, S. M., & Charney, D. S. (2003a). Kortisol response to a cognitive stress challenge in posttraumatic stress disorder (PTSD) related to childhood abuse. Psychoneuroendocrinology, 28, 733–750.
Bremner, J. D., Vythilingam, M., Vermetten, E., Southwick, S. M., McGlashan, T., Nazeer, A., Khan, S., Vaccarino, L. V., Soufer, R., Garg, P. K., Ng, C. K., Staib, L. H., Duncan, J. S., & Charney, D. S. (2003b). MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder. American Journal of Psychiatry, 160, 924–932.
Brewin, C. R., Dalgleish, T., & Joseph, S. (1996). A dual representation theory of posttraumatic stress disorder. Psychological Review, 103, 670–686.
Cabeza, R., & Nyberg, L. (2000). Imaging cognition II: An empirical review of 275 PET and fMRI studies. Journal of Cognitive Neuroscience, 12, 1–47.
Calem, M., Bromis, K., McGuire, P., Morgan, C., & Kempton, M. J. (2017). Meta-analysis of associations between childhood adversity and hippocampus and amygdala volume in non-clinical and general population samples. Neuroimage Clinical, 22(14), 471–479.
Cohen, H., Benjamin, J., Kaplan, Z., & Kotler, M. (2000). Administration of high-dose ketoconazole, an inhibitor of steroid synthesis, prevents posttraumatic anxiety in an animal model. European Neuropsychopharmacology, 10, 429–435.
Davis, M., Ressler, K., Rothbaum, B. O., & Richardson, R. (2006). Effects of D-cycloserine on extinction: Translation from preclinical to clinical work. Biological Psychiatry, 60, 369–375.
De Quervain, D. J. (2006). Glukokortikoid-induced inhibition of memory retrieval: Implications for posttraumatic stress disorder. The Annals of the New York Academy of Sciences, 1071, 216–220.
De Quervain, D. J., Henke, K., Aerni, A., Treyer, V., McGaugh, J. L., Berthold, T., Nitsch, R. M., Buck, A., Roozendaal, B., & Hock, C. (2003). Glukokortikoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe. European Journal of Neuroscience, 17, 1296–1302.
De Quervain, D. J., Roozendaal, B., & McGaugh, J. L. (1998). Stress and glucocorticoids impair retrieval of long-term spatial memory. Nature, 394, 787–790.
De Quervain, D. J., Roozendaal, B., Nitsch, R. M., McGaugh, J. L., & Hock, C. (2000). Acute cortisone administration impairs retrieval of long–term declarative memory in humans. Nature Neuroscience, 3, 313–314.
Elzinga, B. M., & Bremner, J. D. (2002). Are the neural substrates of memory the final common pathway in PTSD? Journal of Affective Disorders, 70, 1–17.
Elzinga, B. M., Schmahl, C. S., Vermetten, E., van Dyck, R., & Bremner, J. D. (2003). Higher kortisol levels following exposure to traumatic reminders in abuse-related PTSD. Neuropsychopharmacology, 28, 1656–1665.
Engelhard, I. M., Olatunji, B. O., & de Jong, P. J. (2011). Disgust and the development of posttraumatic stress among soldiers deployed to Afghanistan. Journal of Anxiety Disorders, 25, 58–63.
Etkin, A., & Wager, T. D. (2007). Functional neuroimaging of anxiety: A meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. American Journal of Psychiatry, 164, 1476–1488.
Frewen, P. A., & Lanius, R. A. (2006). Toward a psychobiology of posttraumatic self-dysregulation: Reexperiencing, hyperarousal, dissociation, and emotional numbing. The Annals of the New York Academy of Sciences, 1071, 110–124.
Geuze, E., Westenberg, H. G. M., Jochims, A., De Kloet, C. S., Bohus, M., Vermetten, E., & Schmahl, C. (2007). Altered pain processing in veterans with posttraumatic stress disorder. Archives of General Psychiatry, 64, 76–85.
Gilbertson, M. W., Shenton, M. E., Ciszewski, A., Kasai, K., Lasko, N. B., Orr, S. P., & Pitman, R. K. (2002). Smaller hippocampal volume predicts pathological vulnerability to psychological trauma. Nature Neuroscience, 5, 1242–1247.
Golub, Y., Kaltwasser, S. F., Mauch, C. P., Herrmann, L., Schmidt, U., Holsboer, F., Czisch, M., & Wotjak, C. T. (2011). Reduced hippocampus volume in the mouse model of posttraumatic stress disorder. Journal of Psychiatric Research, 45, 650–659.
Guastella, A. J., Dadds, M. R., Lovibond, P. F., Mitchell, P., & Richardson, R. (2007). A randomized controlled trial of the effect of D-cycloserine on exposure therapy for spider fear. Journal of Psychiatric Research, 41, 466–471.
Guastella, A. J., Richardson, R., Lovibond, P. F., Rapee, R. M., Gaston, J. E., Mitchell, P., & Dadds, M. R. (2008). A randomized controlled trial of D-cycloserine enhancement of exposure therapy for social anxiety disorder. Biological Psychiatry, 63, 544–549.
Gurvits, T. V., Shenton, M. E., Hokama, H., Ohta, H., Lasko, N. B., Gilbertson, M. W., Orr, S. P., Kikinis, R., Jolesz, F. A., McCarley, R. W., & Pitman, R. K. (1996). Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. Biological Psychiatry, 40, 1091–1099.
Hellhammer, D. H., & Wade, S. (1993). Endocrine correlates of stress vulnerability. Psychotherapy and Psychosomatics, 60, 8–17.
Herry, C., & Mons, N. (2004). Resistance to extinction is associated with impaired immediate early gene induction in medial prefrontal cortex and amygdala. European Journal of Neuroscience, 20, 781–790.
Hofmann, S. G., Meuret, A. E., Smits, J. A., et al. (2006). Augmentation of exposure therapy with D-cycloserine for social anxiety disorder. Archives of General Psychiatry, 63, 298–304.
Kasai, K., Yamasue, H., Gilbertson, M. W., Shenton, M. E., Rauch, S. L., & Pitman, R. K. (2008). Evidence for acquired pregenual anterior cingulated gray matter loss from a twin study of combat-related posttraumatic stress disorder. Biological Psychiatry, 63, 550–556.
Klaassens, E. R., Giltay, E. J., Cuijpers, P., van Veen, T., & Zitman, F. G. (2012). Adulthood trauma and HPA-axis functioning in healthy subjects and PTSD patients: A meta-analysis. Psychoneuroendocrinology, 37, 317–331.
Krause-Utz, A., Oei, N. Y., Niedtfeld, I., et al. (2012). Influence of emotional distraction on working memory performance in borderline personality disorder. Psychological Medicine, 42, 2181–2192.
Krause-Utz, A., Winter, D., Schriner, F., Chiu, C. D., Lis, S., Spinhoven, P., Bohus, M., Schmahl, C., & Elzinga, B. M. (2018). Reduced amygdala reactivity and impaired working memory during dissociation in borderline personality disorder. European Archives of Psychiatry and Clinical Neuroscience, 268(4), 401–415.
Krystal, J. H., Karper, L. P., Seibyl, J. P., Freeman, G. K., Delaney, R., Bremner, J. D., Heninger, G. R., Bowers, M. B., Jr., & Charney, D. S. (1994). Subanesthetic effects of the NMDA antagonist, ketamine, in humans: Psychotomimetic, perceptual, cognitive, and neuroendocrine effects. Archives of General Psychiatry, 51, 199–214.
Kushner, M. G., Kim, S. W., Donahue, C., Thuras, P., Adson, D., Kotlyar, M., McCabe, J., Peterson, J., & Foa, E. B. (2007). D-cycloserine augmented exposure therapy for obsessive-compulsive disorder. Biological Psychiatry, 62, 835–838.
Lanius, R. A., Hopper, J. W., & Menon, R. S. (2003). Individual differences in a husband and wife who developed PTSD after a motor vehicle accident: A functional MRI case study. American Journal of Psychiatry, 160, 667–669.
Lanius, R. A., Vermetten, E., Loewenstein, R. J., Brand, B., Schmahl, C., Bremner, J. D., & Spiegel, D. (2010). Emotion modulation in PTSD: Clinical and neurobiological evidence for a dissociative subtype. American Journal of Psychiatry, 167, 640–647.
Lanius, R. A., Williamson, P. C., Bluhm, R. L., Densmore, M., Boksman, K., Neufeld, R. W. J., Gati, J. S., & Menon, R. S. (2005). Functional connectivity of dissociative responses in posttraumatic stress disorder: A functional magnetic resonance imaging investigation. Biological Psychiatry, 57, 873–884.
Lanius, R. A., Williamson, P. C., Boksman, K., Densmore, M., Gupta, M., Neufeld, R. W. J., Gati, J. S., & Menon, R. S. (2002). Brain activation during script-driven imagery induced dissociative responses in PTSD: A functional magnetic resonance imaging investigation. Biological Psychiatry, 52, 305–311.
Lanius, R. A., Williamson, P. C., Densmore, M., Boksman, K., Gupta, M. A., Neufeld, R. W., Gati, J. S., & Menon, R. S. (2001). Neural correlates of traumatic memories in posttraumatic stress disorder: A functional MRI investigation. American Journal of Psychiatry, 158, 1920–1922.
Lippmann, M., Bress, A., Nemeroff, C. B., Plotsky, P. M., & Monteggia, L. M. (2007). Long-term behavioural and molecular alterations associated with maternal separation in rats. European Journal of Neuroscience, 25, 3091–3098.
Ludäscher, P., Schmahl, C., Feldmann, R. E., Kleindienst, N., Schneider, M., & Bohus, M. (2015). No evidence for differential dose effects of hydrocortisone on intrusive memories in female patients with complex posttraumatic stress disorder – A randomized, double-blind, placebo-controlled, crossover study. Journal of Psychopharmacology, 29, 1077–1084.
Ludäscher, P., Valerius, G., Stiglmayr, C., Mauchnik, J., Lanius, R., Bohus, M., & Schmahl, C. (2010). Pain sensitivity and neural processing during dissociative states in patients with borderline personality disorder with and without comorbid PTSD: A pilot study. Journal of Psychiatry and Neuroscience, 35, 177–184.
Mataix-Cols, D., Fernández de la Cruz, L., Monzani, B., Rosenfield, D., Andersson, E., Pérez-Vigil, A., Frumento, P., de Kleine, R. A., Difede, J., Dunlop, B. W., Farrell, L. J., Geller, D., Gerardi, M., Guastella, A. J., Hofmann, S. G., Hendriks, G. J., Kushner, M. G., Lee, F. S., Lenze, E. J., … Thuras, P. (2017). D-Cycloserine augmentation of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders: A systematic review and meta-analysis of individual participant data. JAMA Psychiatry, 74(5), 501–510.
McAllister-Williams, R. H., & Rugg, M. D. (2002). Effects of repeated cortisol administration on brain potential correlates of episodic memory retrieval. Psychopharmacology, 60, 74–83.
McLean, C. P., & Foa, E. B. (2017). Emotions and emotion regulation in posttraumatic stress disorder. Current Opinion in Psychology, 14, 72–77.
Meewisse, M.-L., Reitsma, J. B., De Vries, G.-J., Gersons, G. P. R., & Olff, M. (2007). Cortisol and posttraumatic stress disorder in adults. Systematic review and meta-analysis. British Journal of Psychiatry, 191, 387–392.
Milad, M. R., Pitman, R. K., Ellis, C. B., Gold, A. L., Shin, L. M., Lasko, N. B., Zeidan, M. A., Handwerger, K., Orr, S. P., & Rauch, S. L. (2009). Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder. Biological Psychiatry, 66, 1075–1082.
Morris, M. C., Compas, B. E., & Garber, J. (2012). Relations among posttraumatic stress disorder, comorbid major depression, and HPA function: A systematic review and meta-analysis. Clinical Psychology Review, 32, 301–315.
Newcomer, J. W., Farber, N. B., Jevtovic-Todorovic, V., Selke, G., Melson, A. K., Hershey, T., Craft, S., & Olney, J. W. (1998). Ketamine-induced NMDA receptor hypofunction as a model of memory impairment and psychosis. Neuropsychopharmacology, 20, 106–118.
Nicholson, A., Rabellino, D., Densmore, M., Frewen, P., Paret, C., Kluetsch, R., Schmahl, C., Theberge, J., Neufeld, R., McKinnon, M., Reiss, J., Jetly, R., & Lanius, R. (2017). The neurobiology of emotion regulation in posttraumatic stress disorder: Amygdala downregulation via real-time fMRI neurofeedback. Human Brain Mapping, 38, 541–560.
Nuller, Y. L., Morozova, M. G., Kushnir, O. N., & Hamper, N. (2001). Effect of naloxone therapy on depersonalization. Journal of Psychopharmacology, 15, 93–95.
Olatunji, B. O., Babson, K. A., Smith, R. C., Feldner, M. T., & Connolly, K. M. (2009). Gender as a moderator of the relation between PTSD and disgust: A laboratory test employing individualized script-driven imagery. Journal of Anxiety Disorders, 23, 1091–1097.
Ori, R., Amos, T., Bergman, H., Soares-Weiser, K., Ipser, J. C., & Stein, D. J. (2015). Augmentation of cognitive and behavioural therapies (CBT) with d-cycloserine for anxiety and related disorders. Cochrane Database of Systematic Reviews, 10(5), CD007803.
Oye, I., Paulsen, O., & Maurset, A. (1992). Effects of ketamine on sensory perception: Evidence for a role of N-methyl-D-aspartate receptors. Journal of Pharmacology and Experimental Therapeutics, 260, 1209–1213.
Paquette, V., Levesque, J., Mensour, B., Leroux, J. M., Beaudoin, G., Bourgouin, P., & Beauregard, M. (2003). “Change the mind and you change the brain”: Effects of cognitive behavioral therapy on the neural correlates of spider phobia. NeuroImage, 18, 401–409.
Pechtel, P., et al. (2014). Sensitive periods of amygdala development: The role of maltreatment in preadolescence. NeuroImage, 97, 236–244.
Phan, K. L., Britton, J. C., Taylor, S. F., Fig, L. M., & Liberzon, I. (2006). Corticolimbic blood flow during nontraumatic emotional processing in posttraumatic stress disorder. Archives of General Psychiatry, 63, 184–192.
Phelps, E. A., & LeDoux, J. E. (2005). Contributions of the amygdala to emotion processing: From animal models to human behavior. Neuron, 48, 175–187.
Philipsen, A., Schmahl, C., & Lieb, K. (2004). Naloxone in the treatment of acute dissociative states in female patients with borderline personality disorder. Pharmacopsychiatry, 37, 196–199.
Phillips, M. L., Williams, L. M., Heining, M., Herba, C. M., Russell, T., Andrew, C., Bullmore, E. T., Brammer, M. J., Williams, S. C., Morgan, M., Young, A. W., & Gray, J. A. (2004). Differential neural responses to overt and covert presentations of facial expressions of fear and disgust. NeuroImage, 21, 1484–1496.
Phillips, M. L., Young, A. W., Scott, S. K., Calder, A. J., Bullmore, E. T., Perrett, D. I., Rowland, D., Williams, S. C., Gray, J. A., & David, A. S. (1997). A specific neural substrate for perceiving facial expressions of disgust. Nature, 389, 495–498.
Pitman, R. K., van der Kolk, B. A., Orr, S. P., & Greenberg, M. S. (1990). Naloxone-reversible analgesic response to combat-related stimuli in posttraumatic stress disorder. A pilot study. Archives of General Psychiatry, 47, 541–544.
Rauch, S. L., Whalen, P. J., Shin, L. M., McInerney, S. C., Macklin, M. L., Lasko, N. B., Orr, S. P., & Pitman, R. K. (2000). Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: A functional MRI study. Biological Psychiatry, 47, 769–776.
Ressler, K. J., Rothbaum, B. O., Tannenbaum, L., Anderson, P., Graap, K., Zimand, E., Hodges, L., & Davis, M. (2004). Cognitive enhancers as adjuncts to psychotherapy: Use of D-cycloserine in phobic individuals to facilitate extinction of fear. Archives of General Psychiatry, 61, 1136–1144.
Richter-Levin, G. (1998). Acute and long-term behavioral correlates of underwater trauma-potential relevance to stress and post-stress syndromes. Psychiatry Research, 79, 73–83.
Rothbaum, B. O. (2008). Critical parameters for D-cycloserine enhancement of cognitive-behaviorial therapy for obsessive-compulsive disorder. American Journal of Psychiatry, 165, 293–296.
Rougemont-Bücking, A., Linnman, C., Zeffiro, T. A., Zeidan, M. A., Lebron-Milad, K., Rodriguez-Romaguera, J., Rauch, S. L., Pitman, R. K., & Milad, M. R. (2011). Altered processing of contextual information during fear extinction in PTSD: An fMRI study. CNS Neuroscience & Therapeutics, 17, 227–236.
Rüsch, N., Corrigan, P. W., Bohus, M., Kühler, T., Jacob, G. A., & Lieb, K. (2007). The impact of posttraumatic stress disorder on dysfunctional implicit and explicit emotions among women with borderline personality disorder. Journal of Nervous and Mental Disease, 195, 537–539.
Rüsch, N., Schulz, D., Valerius, G., Steil, R., Bohus, M., & Schmahl, C. (2011). Disgust and implicit self-concept in women with borderline personality disorder and posttraumatic stress disorder. European Archives of Psychiatry and Clinical Neuroscience, 261, 369–376.
Schiller, D., & Phelps, E. A. (2011). Does reconsolidation occur in humans? Frontiers in Behavioral Neuroscience, 17(5), 24.
Schmahl, C., Kleindienst, N., Limberger, M., Ludäscher, P., Mauchnik, J., Deibler, P., Brünen, S., Hiemke, C., Lieb, K., Herpertz, S., Reicherzer, M., Berger, M., & Bohus, M. (2012). Evaluation of naltrexone for dissociative symptoms in borderline personality disorder. International Clinical Psychopharmacology, 27, 61–68.
Schmahl, C., & Stiglmayr, C. (Eds.). (2009). Selbstverletzendes Verhalten bei stress-assoziierten Störungen. Kohlhammer.
Sheridan, M. A., & McLaughlin, K. A. (2014). Dimensions of early experience and neural development: Deprivation and threat. Trends in Cognitive Sciences, 18(11), 580–585.
Shin, L. M., Wright, C. I., Cannistraro, P. A., Wedig, M. M., McMullin, K., Martis, B., Macklin, M. L., Lasko, N. B., Cavanagh, S. R., Krangel, T. S., Orr, S. P., Pitman, R. K., Whalen, P. J., & Rauch, S. L. (2005). A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Archives of General Psychiatry, 62, 273–281.
Siegmund, A., & Wotjak, C. T. (2006). Toward an animal model of posttraumatic stress disorder. The Annals of the New York Academy of Sciences, 1071, 324–334.
Siegmund, A., & Wotjak, C. T. (2007). A mouse model of posttraumatic stress disorder that distinguishes between conditioned and sensitised fear. Journal of Psychiatric Research, 41, 848–860.
Sierra, M., Phillips, M. L., Lambert, M. V., Senior, C., David, A. S., & Krystal, J. H. (2001). Lamotrigine in the treatment of depersonalization disorder. Journal of Clinical Psychiatry, 62, 826–827.
Sippel, L. M., & Marshall, A. D. (2011). Posttraumatic stress disorder symptoms, intimate partner violence perpetration, and the mediating role of shame processing bias. Journal of Anxiety Disorders, 25(7), 903–910.
Stein, M. B., Koverola, C., Hanna, C., Torchia, M. G., & McClarty, B. (1997). Hippocampal volume in women victimized by childhood sexual abuse. Psychological Medicine, 27, 951–959.
Strigo, I. A., Simmons, A. N., Matthews, S. C., Grimes, E. M., & Allard, C. B. (2010). Neural correlates of altered pain response in women with posttraumatic stress disorder from intimate partner violence. Biological Psychiatry, 68, 442–450.
Tüscher, O., Protopopescu, X., Pan, H., Cloitre, M., Butler, T., Goldstein, M., Root, J. C., Engelien, A., Furman, D., Silverman, M., Yang, Y., Gorman, J., LeDoux, J., Silbersweig, D., & Stern, E. (2011). Differential activity of subgenual cingulate and brainstem in panic disorder and PTSD. Journal of Anxiety Disorder, 25, 251–257.
Walker, D. L., Ressler, K. J., Lu, K. T., & Davis, M. (2002). Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats. Journal of Neuroscience, 22, 2343–2351.
Walsh, S. L., Geter-Douglas, B., Strain, E. C., & Bigelow, G. E. (2001). Enadoline and butorphanol: Evaluation of κ-agonists on cocaine pharmacodynamics and cocaine self administration in humans. Journal of Pharmacology and Experimental Therapeutics, 299, 147–158.
Watanabe, Y. E., Gould, H., Cameron, D., Daniels, D., & McEwen, B. S. (1992). Phenytoin prevents stress and corticosterone induced atrophy of CA3 pyramidal neurons. Hippocampus, 2, 431–436.
Wicker, B., Keysers, C., Plailly, J., Royet, J. P., Gallese, V., & Rizzolatti, G. (2003). Both of us disgusted in my insula: The common neural basis of seeing and feeling disgust. Neuron, 40, 655–664.
Wilhelm, S., Buhlmann, U., Tolin, D. F., Meunier, S. A., Pearlson, G. D., Reese, H. E., Cannistraro, P., Jenike, M. A., & Rauch, S. L. (2008). Augmentation of behavior therapy with D-cycloserine for obsessive-compulsive disorder. American Journal of Psychiatry, 165, 335–341.
Williams, L. M., Das, P., Liddell, B., Olivieri, G., Peduto, A., Brammer, M. J., & Gordon, E. (2005). BOLD, sweat and fears: fMRI and skin conductance distinguish facial fear signals. Neuroreport, 16, 49–52.
Wingenfeld, K., Driessen, M., Terfehr, K., Schlosser, N., Carvalho Fernando, S., Otte, C., Beblo, T., Spitzer, C., Löwe, B., & Wolf, O. T. (2012). Cortisol has enhancing, rather than impairing effects on memory retrieval in PTSD. Psychoneuroendocrinology, 37, 1048–1056.
Wolf, E. J., Miller, M. W., Reardon, A. F., Ryabchenko, K. A., Castillo, D., & Freund, R. (2012). A latent class analysis of dissociation and posttraumatic stress disorder. Evidence for a dissociative subtype. Archives of General Psychiatry, 69, 698–705.
Woon, F. L., & Hedges, D. W. (2009). Amygdala volume in adults with posttraumatic stress disorder: A meta-analysis. Journal of Neuropsychiatry and Clinical Neuroscience, 21, 5–12.
Woon, F. L., & Hedges, D. W. (2011). Gender does not moderate hippocampal volume deficits in adults with posttraumatic stress disorder: A meta-analysis. Hippocampus, 21, 243–252.
Woon, F. L., Sood, S., & Hedges, D. W. (2010). Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: A meta-analysis. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34, 1181–1888.
Yehuda, R., Southwick, S. M., Nussbaum, E. L., Giller, E. L., & Mason, J. W. (1991). Low urinary cortisol in PTSD. Journal of Nervous and Mental Disease, 178, 366–369.
Yehuda, R., Teicher, M. H., Trestman, R. L., Levengood, R. A., & Siever, L. J. (1996). Cortisol regulation in posttraumatic stress disorder and major depression: A chronobiological analysis. Biological Psychiatry, 40, 79–88.
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Schmahl, C. (2022). Neurobiology. In: Maercker, A. (eds) Trauma Sequelae. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-64057-9_6
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