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Diagnostik der endogenen Schmerzhemmkapazität und der Schmerzempfindlichkeit

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Schmerztherapie ohne Medikamente
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Zusammenfassung

Die Schmerzhemmung kann mit quantitativen sensorischen Tests und speziell mit dem psychophysiologischen Paradigma „conditioned pain modulation“ (CPM) geprüft werden. Ein konditionierender Reiz aktiviert die Schmerzhemmung, und ein sensorischer Testreiz prüft das Ausmaß. Unter dem „cold pressure test“ liefern Druck- und Hitzetestreize die sichersten Ergebnisse. Gut erkennbare Einflussfaktoren sind zu beachten. Das Risiko bzw. der Stand der Chronifizierung und der Therapieverlauf sind mit der Schmerzempfindlichkeit und -toleranz, der CPM und der „exercise induced hypoalgesia“ einschätzbar. Bei Gesunden sind die Schmerzschwellen und die -toleranz hoch, und physische Belastungen sorgen für eine „exercise induced hypoalgesia“. Schmerzsensibilisierung senkt die Wahrnehmungsgrenze. Physische Belastungen lösen noch eine geringere Hypoalgesie oder eine paradoxe Reaktion aus. Die Offset-Analgesie, die zeitliche Summation von Hitzereizen und der nozizeptive R-III-Reflex sind weitere diagnostische Werkzeuge.

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Literatur

  • Aloisi AM. Gonadal hormones and sex differences in pain reactivity. Clin J Pain. 2003;19(3):168–74.

    PubMed  Google Scholar 

  • Bannister K, Patel R, Goncalves L, Townson L, Dickenson AH. Diffuse noxious inhibitory controls and nerve injury: restoring an imbalance between descending monoamine inhibitions and facilitations. Pain. 2015;156(9):1803–11. https://doi.org/10.1097/j.pain.0000000000000240. PMID 26010460.

    Article  CAS  PubMed  Google Scholar 

  • Bijker L, Sleijser-Koehorst MLS, Coppieters MW, Cuijpers P, Scholten-Peeters GGM. Preferred self-administered questionnaires to assess depression, anxiety and somatization in people with musculoskeletal pain – a modified delphi study. J Pain. 2020;21(3–4):409–17.

    CAS  PubMed  Google Scholar 

  • Bitar N, Marchand S, Potvin S. Pleasant pain relief and inhibitory conditioned pain modulation: a psychophysical study. Pain Res Manag. 2018;2018:1935056. eCollection 2018.

    PubMed  PubMed Central  Google Scholar 

  • Biurrun Manresa JA, Fritsche R, Vuilleumier PH, Oehler C, Mørch CD, Arendt-Nielsen L, Andersen OK, Curatolo M. Is the conditioned pain modulation paradigm reliable? a test-retest assessment using the nociceptive withdrawal reflex. PLoS One. 2014;9(6):e100241. https://doi.org/10.1371/journal.pone.0100241. eCollection 2014.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cathcart S, Winefield AH, Rolan P, Lushington K. Reliability of temporal summation and diffuse noxious inhibitory control. Pain Res Manag. 2009;14:433–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Choy EHS. The role of sleep in pain and fibromyalgia. Nat Rev Rheumatol. 2015;11(9):513–20.

    PubMed  Google Scholar 

  • Choi JC, Park YH, Park SK, Lee JS, Kim J, Choi JI, Yoon KB, Lee S, Lim DE, Choi JY, Kim MH, Park G, Choi SS, Lee JM. Testosterone effects on pain and brain activation patterns. Acta Anaesthesiol Scand. 2017;61(6):668–75. https://doi.org/10.1111/aas.12908.

    Article  CAS  PubMed  Google Scholar 

  • Da Silva JT, Zhang Y, Asgar J, Ro JY, Seminowicz DA. Diffuse noxious inhibitory controls and brain networks are modulated in a testosterone-dependent manner in Sprague Dawley rats. Behav Brain Res. 2018;349:91–7.

    PubMed  PubMed Central  Google Scholar 

  • Dapunt U, Gantz S, Zhuk A, Gather K, Wang H, Schiltenwolf M. Quantitative sensory testing in physically active individuals and patients who underwent multidisciplinary pain therapy in the longitudinal course. J Pain Res. 2018;11:2323–30. https://doi.org/10.2147/JPR.S173000. eCollection 2018.

    Article  PubMed  PubMed Central  Google Scholar 

  • Dave AJ, Selzer F, Losina E, Klara KM, Collins JE, Usiskin I, Band P, Dalury DF, Iorio R, Kindsfater K, Jeffrey N, Katz JN. Is there an association between whole-body pain with osteoarthritis-related knee pain, pain catastrophizing, and mental health? Clin Orthop Relat Res. 2015;473(12):3894–902.

    PubMed  PubMed Central  Google Scholar 

  • Derbyshire SW, Osborn J. Enhancement of offset analgesia during sequential testing. Eur J Pain. 2008;12:980–9.

    CAS  PubMed  Google Scholar 

  • Edwards RR, Ness TJ, Weigent DA, Fillingim RB. Individual differences in diffuse noxious inhibitory controls (DNIC): association with clinical variables. Pain. 2003;106(3):427–37. https://doi.org/10.1016/j.pain.2003.09.005. PMID 14659526.

    Article  PubMed  Google Scholar 

  • Ellingson LD, Koltyn KF, Kim JS, Cook DB. Does exercise induce hypoalgesia through conditioned pain modulation? Psychophysiology. 2014;51(3):267–76. https://doi.org/10.1111/psyp.12168. Epub 2013 Dec 20.

    Article  PubMed  Google Scholar 

  • Ellingson LD, Stegner AJ, Schwabacher IJ, Lindheimer JB, Cook DB. Catastrophizing interferes with cognitive modulation of pain in women with fibromyalgia. Pain Med. 2018;19(12):2408–22.

    PubMed  PubMed Central  Google Scholar 

  • Fillingim RB, King CD, Ribeiro-Dasilva MC, Rahim-Williams B, Riley JL 3rd. Sex, gender, and pain: a review of recent clinical and experimental findings. J Pain. 2009;10(5):447–85.

    PubMed  PubMed Central  Google Scholar 

  • Fingleton C, Smart K, Doody C. Exercise-induced hypoalgesia in people with knee osteoarthritis with normal and abnormal conditioned pain modulation. Clin J Pain. 2017;33:395–404.

    PubMed  Google Scholar 

  • Flood A, Waddington G, Thompson K, Cathcart S. Increased conditioned pain modulation in athletes. J Sports Sci. 2017a;35(11):1066–72. https://doi.org/10.1080/02640414.2016.1210196. Epub 2016 Jul 25.

    Article  PubMed  Google Scholar 

  • Flood A, Waddington G, Cathcart S. Examining the relationship between endogenous pain modulation capacity and endurance exercise performance. Res Sports Med. 2017b;25(3):300–12. https://doi.org/10.1080/15438627.2017.1314291. Epub 2017a Apr 10.

    Article  PubMed  Google Scholar 

  • Flood A, Waddington G, Keegan RJ, Thompson KG, Cathcart S. The effects of elevated pain inhibition on endurance exercise performance. PeerJ. 2017c;5:e3028. https://doi.org/10.7717/peerj.3028. eCollection 2017.

    Article  PubMed  PubMed Central  Google Scholar 

  • Freeman R, Baron R, Bouhassira D, Cabrera J, Emir B. Sensory profiles of patients with neuropathic pain based on the neuropathic pain symptoms and signs. Pain. 2014;155(2):367–76. https://doi.org/10.1016/j.pain.2013.10.023. Epub 2013 Oct 25.

    Article  PubMed  Google Scholar 

  • Freidl M, Berger P, Topitz A, Katschnig H, Williams J, Zsuzsa L, Sibitz I. Pain symptoms as predictors of depressive or anxiety disorders in patients with physical illness. Psychiatr Prax. 2016;43(5):273–8.

    PubMed  Google Scholar 

  • Gibson SJ, Farrell M. A review of age differences in the neurophysiology of nociception and the perceptual experience of pain. Clin J Pain. 2004;20:227–39.

    PubMed  Google Scholar 

  • Goffaux P, Redmond WJ, Rainville P, Marchand S. Descending analgesia – when the spine echoes what the brain expects. Pain. 2007;130:137–43.

    PubMed  Google Scholar 

  • Gracely RH. Studies of pain in human subjects. In: Wall & Melzack’s textbook of pain. Philadelphia, PA: Elsevier Health Sciences; 2013. S. 283–300.

    Google Scholar 

  • Graven-Nielsen T, Mense S, Arendt-Nielsen L. Painful and non-painful pressure sensations from human skeletal muscle. Exp Brain Res. 2004;159:273–83.

    PubMed  Google Scholar 

  • Graven-Nielsen T, Vaegter HB, Finocchietti S, Handberg G, Arendt-Nielsen L. Assessment of musculoskeletal pain sensitivity and temporal summation by cuff pressure algometry: a reliability study. Pain. 2015;156:2193–202.

    PubMed  Google Scholar 

  • Greenspan JD, Craft RM, LeResche L, Arendt-Nielsen L, Berkley KJ, Fillingim RB, Gold MS, Holdcroft A, Lautenbacher S, Mayer EA, Mogil JS, Murphy AZ, Traub RJ. Studying sex and gender differences in pain and analgesia: a consensus report. Pain. 2007;132(Suppl. 1):S26–45.

    PubMed  PubMed Central  Google Scholar 

  • Grill JD, Coghill RC. Transient analgesia evoked by noxious stimulus offset. J Neurophysiol. 2002;87:2205–8. [PubMed: 11929939].

    PubMed  Google Scholar 

  • Guasti L, Merlo B, Verga R, Cattaneo R, Gaudio G, Bianchi L, Zanzi P, Grandi AM, Bossi PM, Venco A. Effects of arithmetic mental stress test on hypertension-related hypalgesia. J Hypertens. 1995;13(12 Pt 2):1631–5.

    CAS  PubMed  Google Scholar 

  • Hermans L, Calders P, Van Oosterwijck J, Verschelde E, Bertel E, Meeus M. An overview of offset analgesia and the comparison with conditioned pain modulation: a systematic literature review. Pain Physician. 2016;19(6):307–26.

    PubMed  Google Scholar 

  • Herrero JF, Laird JM, Lopez-Garcia JA. Wind-up of spinal cord neurones and pain sensation: much ado about something? Prog Neurobiol. 2000;61:169–203. [PubMed: 10704997].

    CAS  PubMed  Google Scholar 

  • Höffken O, Özgul ÖS, Enax-Krumova EK, Tegenthoff M, Maier C. Evoked potentials after painful cutaneous electrical stimulation depict pain relief during a conditioned pain modulation. BMC Neurol. 2017;17(1):167. https://doi.org/10.1186/s12883-017-0946-7. [PubMed: 28851323].

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hu L, Cai MM, Xiao P, Luo F, Iannetti GD. Human brain responses to concomitant stimulation of a-delta and C nociceptors. J Neurosci. 2014;34:11439–51. https://doi.org/10.1523/JNEUROSCI.1355-14.2014.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Imai Y, Petersen KK, Morch CD, Arendt Nielsen L. Comparing test-retest reliability and magnitude of conditioned pain modulation using different combinations of test and conditioning stimuli. Somatosens Mot Res. 2016a;33:169–77.

    CAS  PubMed  Google Scholar 

  • Imai Y, Petersen KK, Morch CD, Arendt Nielsen L. Comparing test-retest reliability and magnitude of conditioned pain modulation using different combinations of test and conditioning stimuli. Somatosens Mot Res. 2016b;33:1–9.

    Google Scholar 

  • Jones MD, Nuzzo JL, Taylor JL, Barry BK. Aerobic exercise reduces pressure more than heat pain sensitivity in healthy adults. Pain Med. 2019;20(8):1534–46. https://doi.org/10.1093/pm/pny289.

    Article  PubMed  Google Scholar 

  • Jurth C, Rehberg B, von Dincklage F. Reliability of subjective pain ratings and nociceptive flexion reflex responses as measures of conditioned pain modulation. Pain Res Manag. 2014;19(2):93–6. Epub 2014 Feb 19.

    PubMed  PubMed Central  Google Scholar 

  • Karmann AJ, Kundermann B, Lautenbacher S. Schlafentzug und Schmerz: Ein Review der neuesten Literatur. Schmerz. 2014;28(2):141–6. https://doi.org/10.1007/s00482-014-1394-6.

    Article  CAS  PubMed  Google Scholar 

  • Kennedy DL, Kemp HI, Ridout D, Yarnitsky D, Rice AS. Reliability of conditioned pain modulation: a systematic review. Pain. 2016;157(11):2410–9.

    PubMed  PubMed Central  Google Scholar 

  • Khan J, Korczeniewska O, Benoliel R, Kalladka M, Eliav E, Nasri-Heir C. Age and gender differences in mechanically induced intraoral temporal summation and conditioned pain modulation in healthy subjects. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;126(2):134–41. https://doi.org/10.1016/j.oooo.2018.03.021. Epub 2018 Apr 13.

    Article  PubMed  Google Scholar 

  • Kunz M, Mohammadian P, Renner B, Roscher S, Kobal G, Lautenbacher S. Chemo-somatosensory evoked potentials: a sensitive tool to assess conditioned pain modulation? Somatosens Mot Res. 2014;31(2):100–10. https://doi.org/10.3109/08990220.2014.887562. Epub 2014 Feb 25.

    Article  PubMed  Google Scholar 

  • Kurata J. Neural mechanisms of offset analgesia. Adv Exp Med Biol. 2018;1099:141–6.

    CAS  PubMed  Google Scholar 

  • Laube W. Muskelaktivität: Prägung des ZNS und endokrine Funktion – somatische oder degenerativ-nozizeptive Körperstruktur. Man Med. 2013;51:141–50. https://doi.org/10.1007/s00337-012-0989-1.

    Article  Google Scholar 

  • Lautenbacher S, Peters JH, Heesen M, Scheel J, Kunz M. Age changes in pain perception: a systematic-review and meta-analysis of age effects on pain and tolerance thresholds. Neurosci Biobehav Rev. 2017;75:104–13.

    PubMed  Google Scholar 

  • Leknes S, Brooks JCW, Wiech K, Tracey I. Pain relief as an opponent process: a psychophysical investigation. Eur J Neurosci. 2008;28(4):794–801.

    PubMed  Google Scholar 

  • Lewis GN, Rice DA, McNair PJ. Conditioned pain modulation in populations with chronic pain: a systematic review and metaanalysis. J Pain. 2012a;13:936–44.

    PubMed  Google Scholar 

  • Lewis GN, Heales L, Rice DA, Rome K, McNair PJ. Reliability of the conditioned pain modulation paradigm to assess endogenous inhibitory pain pathways. Pain Res Manag. 2012b;17(2):98–102.

    PubMed  PubMed Central  Google Scholar 

  • Lewis GN, Rice DA, Jourdain K, McNair PJ. Influence of stimulation location and posture on the reliability and comfort of the nociceptive flexion reflex. Pain Res Manag. 2012c;17:110–4.

    PubMed  PubMed Central  Google Scholar 

  • Lie MU, Petriu E, Matre D, Hansson P, Andersen OK, Zwart JA, Nilsen KB. Psychophysical or spinal reflex measures when assessing conditioned pain modulation? Eur J Pain. 2019;23(10):1879–89. https://doi.org/10.1002/ejp.1462. Epub 2019 Jul 29.

    Article  PubMed  Google Scholar 

  • Ligato D, Petersen KK, Mørch CD, Arendt-Nielsen L. Offset analgesia: the role of peripheral and central mechanisms. Eur J Pain. 2018;22(1):142–9.

    CAS  PubMed  Google Scholar 

  • Lindskou TA, Christensen SW, Graven-Nielsen T. Cuff algometry for estimation of hyperalgesia and pain summation. Pain Med. 2017;18(3):468–76. https://doi.org/10.1093/pm/pnw168.

    Article  PubMed  Google Scholar 

  • Manafi Khanian B, Arendt-Nielsen L, Kjaer Petersen K, Samani A, Graven-Nielsen T. Interface pressure behavior during painful cuff algometry. Pain Med. 2016;17:915–23.

    PubMed  Google Scholar 

  • Manafi-Khanian B, Arendt-Nielsen L, Frokjaer JB, Graven-Nielsen T. Deformation and pressure propagation in deep somatic tissue during painful cuff algometry. Eur J Pain. 2015;19:1456–66.

    CAS  PubMed  Google Scholar 

  • Marouf R, Piché M, Rainville P. Is temporal summation of pain and spinal nociception altered during normal aging? Pain. 2015;156(10):1945–53.

    PubMed  PubMed Central  Google Scholar 

  • Mauderli AP, Vierck CJ, Cannon RL, Rodrigues A, Shen C. Relationships between skin temperature and temporal summation of heat and cold pain. J Neurophysiol. 2003;90:100–9. [PubMed: 12843304].

    PubMed  Google Scholar 

  • McPhee M, Graven-Nielsen T. Alterations in temporal summation of pain and conditioned pain modulation across an episode of experimental exercise-induced low back pain. J Pain. 2019;20(3):264–76.

    PubMed  Google Scholar 

  • Moont R, Crispel Y, Lev R, Pud D, Yarnitsky D. Temporal changes in cortical activation during conditioned pain modulation (CPM), a LORETA study. Pain. 2011;152(7):1469–77. Epub 2011 Feb 19.

    PubMed  Google Scholar 

  • Moont R, Crispel Y, Lev R, Pud D, Yarnitsky D. Temporal changes in cortical activation during distraction from pain: a comparative LORETA study with conditioned pain modulation. Brain Res. 2012;30(1435):105–17. https://doi.org/10.1016/j.brainres.2011.11.056. Epub 2011 Dec 6.

    Article  CAS  Google Scholar 

  • Nahman-Averbuch H, Yarnitzky D, Granovsky Y, Gerber E, Dagul P, Granot M. The role of stimulation parameters on the conditioned pain modulation response. Scand J Pain. 2013a;4:10–4.

    PubMed  Google Scholar 

  • Nahman-Averbuch H, Granovsky Y, Coghill RC, Yarnitsky D, Sprecher E, Weissman-Fogel I. Waning of ‘conditioned pain modulation’: a novel expression of subtle pronociception in migraine. Headache. 2013b;53(7):1104–15.

    PubMed  Google Scholar 

  • Nahman-Averbuch H, Martucci KT, Granovsky Y, Weissman-Fogel I, Yarnitsky D, Coghill RC. Distinct brain mechanisms support spatial vs temporal filtering of nociceptive information. Pain. 2014;155(12):2491–501. https://doi.org/10.1016/j.pain.2014.07.008. Epub 2014 Jul 15.

    Article  PubMed  PubMed Central  Google Scholar 

  • Naugle KM, Fillingim RB, Riley JL 3rd. A meta-analytic review of the hypoalgesic effects of exercise. J Pain. 2012;13(12):1139–50. [PubMed: 23141188].

    PubMed  PubMed Central  Google Scholar 

  • Niesters M, Proto PL, Aarts L, Sarton EY, Drewes AM, Dahan A. Tapentadol potentiates descending pain inhibition in chronic pain patients with diabetic polyneuropathy. Br J Anaesth. 2014;113(1):148–56. https://doi.org/10.1093/bja/aeu056. PMID 24713310.

    Article  CAS  PubMed  Google Scholar 

  • Nir RR, Yarnitsky D. Conditioned pain modulation. Curr Opin Support Palliat Care. 2015;9(2):131–7. https://doi.org/10.1097/SPC.0000000000000126.

    Article  PubMed  Google Scholar 

  • Nissen TD, Mørch CD, Arendt-Nielsen L, Drewes AM, Olesen AE. Offset analgesia is not affected by cold pressor induced analgesia. Scand J Pain. 2018;18(4):695–701. https://doi.org/10.1515/sjpain-2018-0082.

    Article  PubMed  Google Scholar 

  • Olesen SS, Van Goor H, Bouwense SAW, Wilder-Smith OHG, Drewes AM. Reliability of static and dynamic quantitative sensory testing in patients with painful chronic pancreatitis. Reg Anesth Pain Med. 2012;37(5):530–36.

    Google Scholar 

  • Pud D, Granovsky Y, Yarnitsky D. The methodology of experimentally induced diffuse noxious inhibitory control (DNIC)-like effect in humans. Pain. 2009;144(1-2):16–9. https://doi.org/10.1016/j.pain.2009.02.015. Epub 2009 Apr 8.

    Article  PubMed  Google Scholar 

  • Rosa C, Vignocchi G, Panattoni E, Rossi B, Ghione S. Relationship between increased blood pressure and hypoalgesia: additional evidence for the existence of an abnormality of pain perception in arterial hypertension in humans. J Hum Hypertens. 1994;8(2):119–26.

    CAS  PubMed  Google Scholar 

  • Roy M, Lebuis A, Peretz I, Rainville P. The modulation of pain by attention and emotion: a dissociation of perceptual and spinal nociceptive processes. Eur J Pain. 2011;15(641):e1–10.

    Google Scholar 

  • Sandrini G, Serrao M, Rossi P, Romaniello A, Cruccu G, Willer JC. The lower limb flexion reflex in humans. Prog Neurobiol. 2005;77:353–95. [PubMed: 16386347].

    PubMed  Google Scholar 

  • Schertzinger M, Wesson-Sides K, Parkitny L, Younger J. Daily fluctuations of progesterone and testosterone are associated with fibromyalgia pain severity. J Pain. 2018;19(4):410–7. https://doi.org/10.1016/j.jpain.2017.11.013. Epub 2017 Dec 14.

    Article  CAS  PubMed  Google Scholar 

  • Skyt I, Moslemi K, Baastrup C, Grosen K, Svensson P, Jensen TS, et al. Does conditioned pain modulation predict the magnitude ofplacebo effects in patients with neuropathic pain? Eur J Pain (London, England). 2018;22(4):784–92. https://doi.org/10.1002/ejp.1164.

    Article  CAS  Google Scholar 

  • Sleijser-Koehorst MLS, Bijker L, Cuijpers P, Scholten-Peeters GGM, Coppieters MW. Preferred self-administered questionnaires to assess fear of movement, coping, self-efficacy, and catastrophizing in patients with musculoskeletal pain – a modified Delphi study. Pain. 2019;160(3):600–6.

    PubMed  Google Scholar 

  • Staud R, Craggs JG, Robinson ME, Perlstein WM, Price DD. Brain activity related to temporal summation of C-fiber evoked pain. Pain. 2007;129(1–2):130–42.

    PubMed  Google Scholar 

  • Stolzman S, Danduran M, Hunter SK, Bement MH. Pain response after maximal aerobic exercise in adolescents across weight status. Med Sci Sports Exerc. 2015;47(11):2431–40. [PubMed:25856681].

    PubMed  PubMed Central  Google Scholar 

  • Street LM, Harris L, Curry RS, Eisenach JC. Capsaicin-induced Pain and Sensitisation in the Postpartum Period. Br J Anaesth. 2019;122(1):103–10. https://doi.org/10.1016/j.bja.2018.09.026. Epub 2018 Nov 16.

    Article  CAS  PubMed  Google Scholar 

  • Stroemel-Scheder C, Karmann AJ, Ziegler E, Heesen M, Knippenberg-Bigge K, Lang PM, Lautenbacher S. Sleep, experimental pain and clinical pain in patients with chronic musculoskeletal pain and healthy controls. J Pain Res. 2019;12:3381–93. eCollection 2019.

    PubMed  PubMed Central  Google Scholar 

  • Szikszay TM, Adamczyk WM, Luedtke K. The magnitude of offset analgesia as a measure of endogenous pain modulation in healthy participants and patients with chronic pain: a systematic review and meta-analysis. Clin J Pain. 2019;35(2):189–204. https://doi.org/10.1097/AJP.0000000000000657.

    Article  PubMed  Google Scholar 

  • Umeda M, Newcomb LW, Ellingson LD, Koltyn KF. Examination of the dose-response relationship between pain perception and blood pressure elevations induced by isometric exercise in men and women. Biol Psychol. 2010;85:90–6.

    PubMed  Google Scholar 

  • Vaegter HB, Handberg G, Graven-Nielsen T. Similarities between exercise-induced hypoalgesia and conditioned pain modulation in humans. Pain. 2014;155(1):158–67.

    PubMed  Google Scholar 

  • Vaegter HB, Handberg G, Jorgensen MN, Kinly A, Graven-Nielsen T. Aerobic exercise and cold pressor test induce hypoalgesia in active and inactive men and women. Pain Med. 2015;16:923–33.

    PubMed  Google Scholar 

  • Vaegter HB, Handberg G, Graven-Nielsen T. Hypoalgesia after exercise and the cold pressor test is reduced in chronic musculoskeletal pain patients with high pain sensitivity. Clin J Pain. 2016;32(1):58–69.

    PubMed  Google Scholar 

  • Valencia C, Kindler LL, Fillingim RB, George SZ. Investigation of central pain processing in shoulder pain: converging results from two musculoskeletal pain models. J Pain. 2012;13(1):81–9.

    PubMed  PubMed Central  Google Scholar 

  • Valencia C, Fillingim RB, Bishop M, Wu SS, Wright TW, Moser M, Farmer K, George SZ. Investigation of central pain processing in post-operative shoulder pain and disability. Clin J Pain. 2014;30(9):775–86.

    PubMed  PubMed Central  Google Scholar 

  • Valeriani M, Pazzaglia C, Cruccu G, Truini A. Clinical usefulness of laser evoked potentials. Neurophysiol Clin. 2012;42:345–53. https://doi.org/10.1016/j.neucli.2012.05.002.

    Article  CAS  PubMed  Google Scholar 

  • Vierck CJ, Mauderli AP, Riley JL III. Relationships between the intensity and duration of Peltier heat stimulation and pain magnitude. Exp Brain Res. 2013;225:339–48. [PubMed: 23423165].

    PubMed  Google Scholar 

  • Viggiano A, Zagaria N, Passavanti MB, Pace MC, Paladini A, Aurilio C, Tedesco MA, Natale F, Calabrò R, Monda M, De Luca E. New and low-cost auto-algometry for screening hypertension-associated hypoalgesia. Pain Pract. 2009;9(4):260–5. https://doi.org/10.1111/j.1533-2500.2009.00287.x. Epub 2009 May 15.

    Article  PubMed  Google Scholar 

  • White HD, Robinson TD. A novel use for testosterone to treat central sensitization of chronic pain in fibromyalgia patients. Int Immunopharmacol. 2015;27(2):244–8. https://doi.org/10.1016/j.intimp.2015.05.020. Epub 2015 May 21.

    Article  CAS  PubMed  Google Scholar 

  • Willer JC, Roby A, Le Bars D. Psychophysical and electrophysiological approaches to the pain-relieving effects of heterotopic nociceptive stimuli. Brain. 1984;107:1095–112.

    PubMed  Google Scholar 

  • Williams AE, Miller MM, Bartley EJ, McCabe KM, Kerr KL, Rhudy JL. Impairment of inhibition of trigeminal nociception via conditioned pain modulation in persons with migraine headaches. Pain Med. 2019;20(8):1600–10. https://doi.org/10.1093/pm/pny305.

    Article  PubMed  PubMed Central  Google Scholar 

  • Woolf CJ. What to call the amplification of nociceptive signals in the central nervous system that contribute to widespread pain? Pain. 2014;155:1911–2.

    PubMed  Google Scholar 

  • Yarnitsky D. Conditioned pain modulation (the diffuse noxious inhibitory control-like effect): its relevance for acute and chronic pain states. Curr Opin Anaesthesiol. 2010;23(5):611–5. [PubMed: 20543676].

    PubMed  Google Scholar 

  • Yarnitsky D, Crispel Y, Eisenberg E, Granovsky Y, Ben-Nun A, Sprecher E, Best LA, Granot M. Prediction of chronic post-operative pain: preoperative DNIC testing identifies patients at risk. Pain. 2008;138(1):22–8.

    PubMed  Google Scholar 

  • Yarnitsky D, Arendt-Nielsen L, Bouhassira D, Edwards RR, Fillingim RB, Granot M, Hansson P, Lautenbacher S, Marchand S, Wilder-Smith O. Recommendations on terminology and practice of psychophysical DNIC testing. Eur J Pain. 2010;14(4):339. https://doi.org/10.1016/j.ejpain.2010.02.004. Epub 2010 Mar 12.

    Article  PubMed  Google Scholar 

  • Yarnitsky D, Granot M, Nahman-Averbuch H, Khamaisi M, Granovsky Y. Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy. Pain. 2012;153(6):1193–8. https://doi.org/10.1016/j.pain.2012.02.021. PMID 22480803.

    Article  CAS  PubMed  Google Scholar 

  • Yarnitsky D, Bouhassira D, Drewes AM, Fillingim RB, Granot M, Hansson P, et al. Recommendations on practice of conditioned pain modulation (CPM) testing. Eur J Pain. 2015;19(6):805–6.

    CAS  PubMed  Google Scholar 

  • Yelle MD, Rogers JM, Coghill RC. Offset analgesia: a temporal contrast mechanism for nociceptive information. Pain. 2008;134:174–86. [PubMed: 17533118].

    PubMed  Google Scholar 

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Laube, W. (2022). Diagnostik der endogenen Schmerzhemmkapazität und der Schmerzempfindlichkeit. In: Schmerztherapie ohne Medikamente. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-63846-0_7

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