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Die aktiven Bausteine der Regulativen Schmerzbehandlung – langfristige anti-nozizeptive periphere und zentrale Reorganisation mit integrierter Qualifizierung der Schmerztoleranz und Schmerzhemmung

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Schmerztherapie ohne Medikamente

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Zusammenfassung

Ermüdende Belastungen sind wichtige Elemente der Schmerztherapie. Die „exercise induced hypoalgesia“ ist ein Therapiereiz. Bei chronischen Schmerzen kann sie gemindert, nicht vorhanden oder paradox sein. Belastungschmerzen haben einen maladaptiven Hintergrund, und gesundes Altern ist keine Schmerzursache.

Die Muskulatur prägt die Körperhomöostase, den Stoffwechsel, das Gehirn und die Schmerzen. Schmerzen verändern die kognitiv-mentalen Funktionen wie die Compliance und Resilienz. Jede Belastungsform ist auch Therapie des Gehirns. Training steht sowohl für Schmerzprävention als auch für Schmerztherapie! Der Muskelstatus ist Marker des Gesundheitsstaus und der Schmerzhemmung und -toleranz.

Die pathophysiologischen und sozialen Faktoren chronischer Schmerzen prägen die Therapie. Das „nozizeptive Gehirn“ muss gefordert werden. Die Wechselbeziehungen zwischen Erkrankung, Schmerzen, Ernährung und Belastungen sind vielfältig. Dosis-Wirkungsbeziehungen der Ernährung sind zz. nicht ableitbar.

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Literatur

  • Adkins DL, Boychuk J, Remple MS, Kleim JA. Motor training induces experience-specific patterns of plasticity across motor cortex and spinal cord. J Appl Physiol. 2006;101(6):1776–82. Epub 2006 Sep 7.

    PubMed  Google Scholar 

  • Ageberg E, Roos EM. Neuromuscular exercise as treatment of degenerative knee disease. Exerc Sport Sci Rev. 2015;43(1):14–22.

    PubMed  Google Scholar 

  • Ageberg E, Link A, Roos EM. Feasibility of neuromuscular training in patients with severe hip or knee OA: the individualized goal-based NEMEX-TJR training program. BMC Musculoskelet Disord. 2010;11:126.

    PubMed  PubMed Central  Google Scholar 

  • Aguilar-Aguilar E, Marcos-Pasero H, Ikonomopoulou MP, Loria-Kohen V. Food Implications in Central Sensitization Syndromes. J Clin Med. 2020;9(12):4106. https://doi.org/10.3390/jcm9124106.

    Article  CAS  PubMed Central  Google Scholar 

  • Aizawa K, Iemitsu M, Maeda S, Mesaki N, Ushida T, Akimoto T. Endurance exercise training enhances local sex steroidogenesis in skeletal muscle. Med Sci Sports Exerc. 2011;43(11):2072–80. https://doi.org/10.1249/MSS.0b013e31821e9d74.

    Article  CAS  PubMed  Google Scholar 

  • Alwarith J, Kahleova H, Rembert E, Yonas W, Dort S, Calcagno M, Burgess N, Crosby L, Barnard ND. Nutrition interventions in rheumatoid arthritis: the potential use of plant-based diets. A review. Front Nutr. 2019;6:141. https://doi.org/10.3389/fnut.2019.00141. eCollection 2019.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ambrose KR, Golightly YM. Physical Exercise as Non-Pharmacological Treatment of Chronic Pain: Why and When. Best Pract Res Clin Rheumatol. 2015;29(1):120–30. https://doi.org/10.1016/j.berh.2015.04.022. Epub 2015 May 23.

  • Andrade A, de Azevedo Klumb Steffens R, Sieczkowska SM, Peyré Tartaruga LA, Torres Vilarino G. A systematic review of the effects of strength training in patients with fibromyalgia: clinical outcomes and design considerations. Adv Rheumatol. 2018;58(1):36. https://doi.org/10.1186/s42358-018-0033-9.

    Article  PubMed  Google Scholar 

  • Andrade A, De Azevedo Klumb Steffens R, Mendes Sieczkowska S, Reis Coimbra D, Torres Vilarino G. Acute effect of strength training on mood of patients with fibromyalgia syndrome. Reumatismo. 2019;71(3):141–7. https://doi.org/10.4081/reumatismo.2019.1169.

    Article  CAS  PubMed  Google Scholar 

  • Angevaren M, Aufdemkampe G, Verhaar HJ, Aleman A, Vanhees L. Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst Rev. 2008;3:CD005381.

    Google Scholar 

  • Anwer S, Alghadir A, Brismée JM. Effect of home exercise program in patients with knee osteoarthritis: a systematic review and meta-analysis. J Geriatr Phys Ther. 2016;39(1):38–48. https://doi.org/10.1519/JPT.0000000000000045.

  • Aosaki T, Tsubokawa H, Ishida A, Watanabe K, Graybiel AM, Kimura M. Responses of tonically active neurons in the primate’ts striatum undergo systematic changes during behavioral sensorimotor conditioning. J Neurosci. 1994;14(6):3969–84.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Beltran-Carrillo VJ, Tortosa-Martinez J, Jennings G, Sanchez ES. Contributions of a group-based exercise program for coping with fibromyalgia: a qualitative study giving voice to female patients. Women Health. 2013;53:612–29.

    PubMed  Google Scholar 

  • Bergamin A, Mantzioris E, Cross G, Deo P, Garg S, Hill AM. Nutraceuticals: reviewing their role in chronic disease prevention and management. Pharmaceut Med. 2019;33(4):291–309. https://doi.org/10.1007/s40290-019-00289-w.

    Article  CAS  PubMed  Google Scholar 

  • Bjørklund G, Dadar M, Chirumbolo S, Aaseth J. Fibromyalgia and nutrition: therapeutic possibilities? Biomed Pharmacother. 2018;103:531–8. https://doi.org/10.1016/j.biopha.2018.04.056. Epub 2018 Apr 24.

    Article  CAS  PubMed  Google Scholar 

  • Bjørklund G, Aaseth J, Doşa MD, Pivina L, Dadar M, Pen JJ, Chirumbolo S. Does diet play a role in reducing nociception related to inflammation and chronic pain? Nutrition. 2019;66:153–65. https://doi.org/10.1016/j.nut.2019.04.007. Epub 2019 Apr 26.

    Article  CAS  PubMed  Google Scholar 

  • Bonkowski MS, Rocha JS, Masternak MM, Al Regaiey KA, Bartke A. Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc Natl Acad Sci U S A. 2006;103(20):7901–5. https://doi.org/10.1073/pnas.0600161103. Epub 2006 May 8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Borenstein DG, Hassett AL, Pisetsky D. Pain management in rheumatology research, training, and practice. Clin Exp Rheumatol. 2017;35(Suppl 107(5)):2–7. Epub 2017 Sep 28.

    PubMed  Google Scholar 

  • Bottini G, Karnath HO, Vallar G, Sterzi R, Frith CD, Frackowiak RS, Paulesu E. Cerebral representations for egocentric space: functional-anatomical evidence from caloric vestibular stimulation and neck vibration. Brain. 2001;124:1182–96.

    CAS  PubMed  Google Scholar 

  • Bove M, Diverio M, Pozzo T, Schieppati M. Neck muscle vibration disrupts steering of locomotion. J Appl Physiol. 2001;91:581–8.

    CAS  PubMed  Google Scholar 

  • Branstrom H, Fahlstrom M. Kinesiophobia in patients with chronic musculoskeletal pain: differences between men and women. J Rehabil Med. 2008;40:375–80.

    PubMed  Google Scholar 

  • Campbell KL, Kam JWY, Neil-Sztramko SE, Liu Ambrose T, Handy TC, Lim HJ, Hayden S, Hsu L, Kirkham AA, Gotay CC, McKenzie DC, Boyd LA. Effect of aerobic exercise on cancer-associated cognitive impairment: a proof-of-concept RCT. Psychooncology. 2018;27(1):53–60. https://doi.org/10.1002/pon.4370. Epub 2017 Feb 10.

    Article  CAS  PubMed  Google Scholar 

  • Ceballos-Laita L, Estébanez-de-Miguel E, Martín-Nieto G, Bueno-Gracia E, Fortún-Agúd M, Jiménez-Del-Barrio S. Effects of non-pharmacological conservative treatment on pain, range of motion and physical function in patients with mild to moderate hip osteoarthritis. A systematic review. Complement Ther Med. 2019;42:214–22. https://doi.org/10.1016/j.ctim.2018.11.021. Epub 2018 Nov 27.

    Article  PubMed  Google Scholar 

  • Cheng JOS, Cheng ST. Effectiveness of physical and cognitive-behavioural intervention programmes for chronic musculoskeletal pain in adults: a systematic review and meta-analysis of randomised controlled trials. PLoS One. 2019;14(10):e0223367. https://doi.org/10.1371/journal.pone.0223367. eCollection 2019.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cook DB, Stegner AJ, Ellingson LD. Exercise alters pain sensitivity in Gulf War veterans with chronic musculoskeletal pain. J Pain. 2010;11:764–72.

    PubMed  Google Scholar 

  • Cope TC, Sokoloff AJ. Orderly recruitment among motoneurons supplying different muscles. J Physiol. 1999;93:81–5.

    CAS  Google Scholar 

  • Coxon JP, Van Impe A, Wenderoth N, Swinnen SP. Aging and inhibitory control of action: cortico-subthalamic connection strength predicts stopping performance. J Neurosci. 2012;32(24):8401–12. https://doi.org/10.1523/JNEUROSCI.6360-11.2012.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Crane JD, Macneil LG, Tarnopolsky MA. Long-term aerobic exercise is associated with greater muscle strength throughout the life span. J Gerontol A Biol Sci Med Sci. 2013;68(6):631–8. https://doi.org/10.1093/gerona/gls237. Epub 2012 Dec 3.J Gerontol A Biol Sci Med Sci. 2013. PMID: 23213030.

    Article  PubMed  Google Scholar 

  • Crist RE, Kapadia MK, Westheimer G, Gilbert CD. Perceptual learning of spatial localization: specificity for orientation, position, and context. J Neurophysiol. 1997;78:2889–94.

    CAS  PubMed  Google Scholar 

  • Desmedt JE, Godaux E. Ballistic contractions in man: characteristic recruitment pattern of single motor units of the tibialis anterior muscle. J Physiol. 1977;264:673–93.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Desmedt JE, Godaux E. Ballistic contractions in fast or slow human muscles: discharge patterns of single motor units. J Physiol. 1978;285:185–96.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Dikalov SI, Dikalova AE. Contribution of mitochondrial oxidative stress to hypertension. Curr Opin Nephrol Hypertens. 2016;25(2):73–80. https://doi.org/10.1097/MNH.0000000000000198.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain—United States, 2016. J Am Med Assoc. 2016;315:1624–45.

    CAS  Google Scholar 

  • Dragan S, Șerban MC, Damian G, Buleu F, Valcovici M, Christodorescu R. Dietary patterns and interventions to alleviate chronic pain. Nutrients. 2020;12(9):2510. https://doi.org/10.3390/nu12092510.

    Article  CAS  PubMed Central  Google Scholar 

  • Du C, Smith A, Avalos M, South S, Crabtree K, Wang W, Kwon YH, Vijayagopal P, Juma S. Blueberries improve pain, gait performance, and inflammation in individuals with symptomatic knee osteoarthritis. Nutrients. 2019;11(2):290. https://doi.org/10.3390/nu11020290.

    Article  CAS  PubMed Central  Google Scholar 

  • Eccleston C, Crombez G. Pain demands attention: a cognitiveaffective model of the interruptive function of pain. Psychol Bull. 1999;125:356–66.

    CAS  PubMed  Google Scholar 

  • Ellingson LD, Koltyn KF, Kim JS, Cook DB. Does exercise induce hypoalgesia through conditioned pain modulation? Psychophysiology. 2014;51(3):267–76. https://doi.org/10.1111/psyp.12168. Epub 2013 Dec 20.

  • Elma Ö, Yilmaz ST, Deliens T, Clarys P, Nijs J, Coppieters I, Polli A, Malfliet A. Chronic musculoskeletal pain and nutrition: where are we and where are we heading? PMR. 2020a;12(12):1268–78. https://doi.org/10.1002/pmrj.12346. Epub 2020 Mar 20.

    Article  Google Scholar 

  • Elma Ö, Yilmaz ST, Deliens T, Coppieters I, Clarys P, Nijs J, Malfliet A. Do nutritional factors interact with chronic musculoskeletal pain? A systematic review. J Clin Med. 2020b;9(3):702. https://doi.org/10.3390/jcm9030702.

    Article  PubMed Central  Google Scholar 

  • Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci USA. 2011;108:3017–22. https://doi.org/10.1073/pnas.1015950108.

    Article  PubMed  PubMed Central  Google Scholar 

  • Fetz EE, Baker MA. Operantly conditioned patterns on precentral unit activity and correlated responses in adjacent cells and contralateral muscles. J Neurophysiol. 1973;36(2):179–204.

    CAS  PubMed  Google Scholar 

  • Fingleton C, Smart K, Doody C. Exercise-induced hypoalgesia in people with knee osteoarthritis with normal and abnormal conditioned pain modulation. Clin J Pain. 2017;33:395–404.

    PubMed  Google Scholar 

  • Firth J, Stubbs B, Vancampfort D, Schuch F, Lagopoulos J, Rosenbaum S, et al. Effect of aerobic exercise on hippocampal volume in humans: a systematic review and meta-analysis. NeuroImage. 2018;166:230–8. https://doi.org/10.1016/j.neuroimage.2017.11.007.

    Article  PubMed  Google Scholar 

  • Fjell AM, Westlye LT, Amlien I, Espeseth T, Reinvang I, Raz N, Agartz I, Salat DH, Greve DN, Fischl B, Dale AM, Walhovd KB. High consistency of regional cortical thinning in aging acros multiple samples. Cereb Cortex. 2009;19:2001–12.

    PubMed  PubMed Central  Google Scholar 

  • Fridén C, Thoors U, Glenmark B, Kosek E, Nordmark B, Lundberg IE, Opava CH. Higher pain sensitivity and lower muscle strength in postmenonpausal women with early rheumatoid arthritis compared with age-matched healthy women--a pilot study. Disabil Rehabil. 2013;35(16):1350–6. https://doi.org/10.3109/09638288.2012.731469. Epub 2013 Jan 18.

    Article  PubMed  Google Scholar 

  • Frontera WR, Meredith CN, O’Reilly KP, Evans WJ. Strength training and determinants of VO2max in older men. J Appl Physiol. 1990;68(1):329–33.

    CAS  PubMed  Google Scholar 

  • Frost H. A chondral modeling theory. Calcif Tissue Int. 1979;28(1):181–200.

    CAS  PubMed  Google Scholar 

  • Frost HM. Pathogenesis of congenital hip dysplasia (CDH). A proposal. Vet Comp Orthop Traumatol. 1989;1:1–10.

    Google Scholar 

  • Frost HM. Skeletal structural adaptations to mechanical usage (SATMU): 3. The hyaline cartilage modeling problem. Anat Rec. 1990;226(4):423–32. https://doi.org/10.1002/ar.1092260404.

    Article  CAS  PubMed  Google Scholar 

  • Frost HM. Biomechanical control of knee alignment: some insights from a new paradigm. Clin Orthop Relat Res. 1997;335:335–42.

    Google Scholar 

  • Frost HM. Joint anatomy, design, and arthroses: insights of the Utah paradigm. Anat Rec. 1999;255(2):162–74. https://doi.org/10.1002/(SICI)1097-0185(19990601)255:2<162::AID-AR6>3.0.CO;2-1.

    Article  CAS  PubMed  Google Scholar 

  • Frost HM. The Utah paradigm of skeletal physiology: an overview of its insights for bone, cartilage and collagenous tissue organs. J Bone Miner Metab. 2000;18:305–16.

    CAS  PubMed  Google Scholar 

  • Frost HM. From Wolff’s law to the Utah paradigm: insights about bone physiology and its clinical applications. Anat Rec. 2001;262:398–419.

    CAS  PubMed  Google Scholar 

  • Frost HM. Bone’s Mechanostat: a 2003 update. Anat Rec. 2003;275A:1081–101.

    Google Scholar 

  • Fuchs J, Prütz F. Prävalenz von Gelenkschmerzen in Deutschland. J Health Monito. 2017;2(3). https://doi.org/10.17886/RKI-GBE-2017-056.

  • Gajsar H, Titze C, Konietzny K, Meyer M, Vaegter HB, Hasenbring MI. Cognitive inhibition correlates with exercise-induced hypoalgesia after aerobic bicycling in pain-free participants. J Pain Res. 2020;13:847–58. https://doi.org/10.2147/JPR.S238718. eCollection 2020.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gallagher B, Tjoumakaris FP, Harwood MI, Good RP, Ciccotti MG, Freedman KB. Chondroprotection and the prevention of osteoarthritis progression of the knee: a systematic review of treatment agents. Am J Sports Med. 2015;43(3):734–44. https://doi.org/10.1177/0363546514533777. Epub 2014 May 27.

    Article  PubMed  Google Scholar 

  • Gay C, Chabaud A, Guilley E, Coudeyre E. Educating patients about the benefits of physical activity and exercise for their hip and knee osteoarthritis. Systematic literature review. Ann Phys Rehabil Med. 2016;59(3):174–83. https://doi.org/10.1016/j.rehab.2016.02.005. Epub 2016 Apr 1.

    Article  CAS  PubMed  Google Scholar 

  • Gdowski GT, McCrea RA. Neck propriorezeptive inputs to primate vestibular nucleus neurons. Exp Brain Res. 2000;135(4):511–26.

    CAS  PubMed  Google Scholar 

  • Geneen LJ, Moore RA, Clarke C, Martin D, Colvin LA, Smith BH. Physical activity and exercise for chronic pain in adults: an overview of Cochrane reviews. Cochrane Database Syst Rev. 2017;4:Cd011279.

    PubMed  Google Scholar 

  • Genel F, Kale M, Pavlovic N, Flood VM, Naylor JM, Adie S. Health effects of a low-inflammatory diet in adults with arthritis: a systematic review and meta-analysis. J Nutr Sci. 2020;9:e37. https://doi.org/10.1017/jns.2020.31. eCollection 2020.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gómez-Cabello A, Ara I, González-Agüero A, Casajús JA, Vicente-Rodríguez G. Effects of training on bone mass in older adults: a systematic review. Sports Med. 2012;42(4):301–25. https://doi.org/10.2165/11597670-000000000-00000.

    Article  PubMed  Google Scholar 

  • Gottliebsen M, Shiguetomi-Medina JM, Rahbek O, Møller-Madsen B. Guided growth: mechanism and reversibility of modulation. J Child Orthop. 2016;10(6):471–7. https://doi.org/10.1007/s11832-016-0778-9. Epub 2016 Nov 8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Guiney H, Machado L. Benefits of regular aerobic exercise for executive functioning in healthy populations. Psychon Bull Rev. 2013;20(1):73–86. https://doi.org/10.3758/s13423-012-0345-4.

    Article  PubMed  Google Scholar 

  • Gunton JE, Girgis CM, Baldock PA, Lips P. Bone muscle interactions and vitamin D. Bone. 2015;80:89–94. https://doi.org/10.1016/j.bone.2015.02.029. Epub 2015 Mar 6.

    Article  CAS  PubMed  Google Scholar 

  • Guo XZ, Shan C, Hou YF, Zhu G, Tao B, Sun LH, Zhao HY, Ning G, Li ST, Liu JM. Osteocalcin ameliorates motor dysfunction in a 6-hydroxydopamine-induced Parkinson’s disease rat model through AKT/GSK3β signaling. Front Mol Neurosci. 2018;11:343. https://doi.org/10.3389/fnmol.2018.00343. eCollection 2018.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hackett J, Naugle KE, Naugle KM. The decline of endogenous pain modulation with aging: a meta-analysis of temporal summation and conditioned pain modulation. J Pain. 2020;21(5–6):514–28. https://doi.org/10.1016/j.jpain.2019.09.005. Epub 2019 Sep 25.

    Article  PubMed  Google Scholar 

  • Hansen S, Vaegter HB, Petersen KK. Pretreatment exercise-induced hypoalgesia is associated with change in pain and function after standardized exercise therapy in painful knee osteoarthritis. Clin J Pain. 2020;36(1):16–24.

    PubMed  Google Scholar 

  • Hartman SJ, Nelson SH, Myers E, Natarajan L, Sears DD, Palmer BW, Weiner LS, Parker BA, Patterson RE. Randomized controlled trial of increasing physical activity on objectively measured and self-reported cognitive functioning among breast cancer survivors: the memory & motion study. Cancer. 2018;124(1):192–202. https://doi.org/10.1002/cncr.30987. Epub 2017 Sep 19.

    Article  PubMed  Google Scholar 

  • Hassett AL, Williams DA. Non-pharmacological treatment of chronic widespread musculoskeletal pain. Best Pract Res Clin Rheumatol. 2011;25:299–309.

    PubMed  Google Scholar 

  • Hawkins S, Wiswell R. Rate and mechanism of maximal oxygen consumption decline with aging: implications for exercise training. Sports Med. 2003;33(12):877–88.

    PubMed  Google Scholar 

  • Henneman E. Relation between size of neurons and their susceptibility to discharge. Science. 1957;126:1345–7.

    Google Scholar 

  • Henneman E, Sojmen G, Carpenter DO. Functional significance of cell size in spinal motoneurones. J Neurophysiol. 1965;28:560–80.

    Google Scholar 

  • Hepple RT, Mackinnon SL, Goodman JM, Thomas SG, Plyley MJ. Resistance and aerobic training in older men: effects on VO2peak and the capillary supply to skeletal muscle. J Appl Physiol. 1997;82(4):1305–10.

    CAS  PubMed  Google Scholar 

  • Herbert RD, Balnave RJ. The effect of position of immobilisation on resting length, resting stiffness, and weight of the soleus muscle of the rabbit. J Orthop Res. 1993;11(3):358–66. https://doi.org/10.1002/jor.1100110307.

    Article  CAS  PubMed  Google Scholar 

  • Herbert RD, Crosbie J. Rest length and compliance of non-immobilised and immobilised rabbit soleus muscle and tendon. Eur J Appl Physiol Occup Physiol. 1997;76(5):472–9. https://doi.org/10.1007/s004210050277.

    Article  CAS  PubMed  Google Scholar 

  • Higgins SC, Adams J, Hughes R. Measuring hand grip strength in rheumatoid arthritis. Rheumatol Int. 2018;38(5):707–14. https://doi.org/10.1007/s00296-018-4024-2. Epub 2018 Apr 6.

    Article  PubMed  Google Scholar 

  • Hodson-Tole EF, Wakeling JM. Motor unit recruitment for dynamic tasks: current understanding and future directions. J Comp Physiol B. 2009;179:57–66.

    PubMed  Google Scholar 

  • Hollands MA, Sorensen KL, Patla AE. Effects of head immobilization on the coordination and control of head and body reorientation and translation during steering. Exp Brain Res. 2001;140(2):223–33.

    CAS  PubMed  Google Scholar 

  • Häkkinen K, Pakarinen A, Kyröläinen H, Cheng S, Kim DH, Komi PV. Neuromuscular adaptations and serum hormones in femals during prolonged power training. Int J Sports Med. 1990;11:91–8.

    Google Scholar 

  • Häkkinen K, Newton RU, Gordon SE, McCormick M, Volek JS, Nidl BC, Gotshalk LA, Cambell WW, Evans WJ, Häkkinen A, Humphries BJ, Kraemer W. Changes in muscle morphology, electromyographic activity, and force production characteristics during progressive strength training in young and older men. J Gerontol A Biol Sci Med Sci. 1998;53:B415–23.

    Google Scholar 

  • Izquierdo M, Häkkinen K, Ibanez J, Garrues M, Antòn A, Zùniga A, Larriòn JL, Gorostiaga EM. Effects of strength training on muscle power and serum hormones in middle-aged and older men. J Appl Physiol. 2001;90:1497–507.

    CAS  PubMed  Google Scholar 

  • Jackson MJ. Redox regulation of adaptive responses in skeletal muscle to contractile activity. Free Radic Biol Med. 2009;47(9):1267–75. Epub 2009 Sep 11.

    CAS  PubMed  Google Scholar 

  • Jähn K, Lara-Castillo N, Brotto L, Mo CL, Johnson ML, Brotto M, Bonewald LF. Skeletal muscle secreted factors prevent glucocorticoid-induced osteocyte apoptosis through activation of β-catenin. Eur Cell Mater. 2012;24:197–209; discussion 209-10. https://doi.org/10.22203/ecm.v024a14.

    Article  PubMed  PubMed Central  Google Scholar 

  • Järvinen M. Immobilization effect on the tensile properties of striated muscle: an experimental study in the rat. Arch Phys Med Rehabil. 1977;58(3):123–7.

    PubMed  Google Scholar 

  • Järvinen MJ, Einola SA, Virtanen EO. Effect of the position of immobilization upon the tensile properties of the rat gastrocnemius muscle. Arch Phys Med Rehabil. 1992;73(3):253–7.

    PubMed  Google Scholar 

  • Järvinen TA, Józsa L, Kannus P, Järvinen TL, Järvinen M. Organization and distribution of intramuscular connective tissue in normal and immobilized skeletal muscles. An immunohistochemical, polarization and scanning electron microscopic study. J Muscle Res Cell Motil. 2002;23(3):245–54. https://doi.org/10.1023/a:1020904518336.

    Article  PubMed  Google Scholar 

  • Kadetoff D, Kosek E. The effects of static muscular contraction on blood pressure, heart rate, pain ratings and pressure pain thresholds in healthy individuals and patients with fibromyalgia. Eur J Pain. 2007;11:39–47.

    PubMed  Google Scholar 

  • Kanazawa I. Osteocalcin as a hormone regulating glucose metabolism. World J Diabetes. 2015;6(18):1345–54. https://doi.org/10.4239/wjd.v6.i18.1345.

    Article  PubMed  PubMed Central  Google Scholar 

  • Karsenty G. The mutual dependence between bone and gonads. J Endocrinol. 2012;213(2):107–14. https://doi.org/10.1530/JOE-11-0452. Epub 2012 Mar 9.

    Article  CAS  PubMed  Google Scholar 

  • Karst M. Chronische Schmerzen – ein Update. Anästh Intensivmed. 2014;55:190–7.

    Google Scholar 

  • Kaushik AS, Strath LJ, Sorge RE. Dietary interventions for treatment of chronic pain: oxidative stress and inflammation. Pain Ther. 2020;9(2):487–98. https://doi.org/10.1007/s40122-020-00200-5. Epub 2020 Oct 21.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kayo AH, Peccin MS, Sanches CM, Trevisani VF. Effectiveness of physical activity in reducing pain in patients with fibromyalgia: a blinded randomized clinical trial. Rheumatol Int. 2012;32:2285–92.

    PubMed  Google Scholar 

  • Keller A, Iriki A, Asanuma H. Identification of neurons producing long-term potentiation in the cat motor cortex: intracellular recordings and labeling. J Comp Neurol. 1990;300(1):47–60.

    CAS  PubMed  Google Scholar 

  • Kelley GA, Kelley KS, Hootman JM, Jones DL. Exercise and global well-being in communitydwelling adults with fibromyalgia: a systematic review with meta-analysis. BMC Public Health. 2010;10:198.

    PubMed  PubMed Central  Google Scholar 

  • Khrimian L, Obri A, Ramos-Brossier M, Rousseaud A, Moriceau S, Nicot AS, Mera P, Kosmidis S, Karnavas T, Saudou F, Gao XB, Oury F, Kandel E, Karsenty G. Gpr158 mediates osteocalcin’s regulation of cognition. J Exp Med. 2017;214(10):2859–73. https://doi.org/10.1084/jem.20171320.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kim DJ, Yu JH, Shin MS, Shin YW, Kim MS. Hyperglycemia reduces efficiency of brain networks in subjects with type 2 diabetes. PLoS One. 2016;11(6):e0157268. https://doi.org/10.1371/journal.pone.0157268. eCollection 2016.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kluding PM, Pasnoor M, Singh R, Jernigan S, Farmer K, Rucker J, Sharma NK, Wright DE. The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy. J Diabetes Complication. 2012;26(5):424–9. https://doi.org/10.1016/j.jdiacomp.2012.05.007. Epub 2012 Jun 18.

    Article  Google Scholar 

  • Kluding PM, Pasnoor M, Singh R, D’Silva LJ, Yoo M, Billinger SA, LeMaster JW, Dimachkie MM, Herbelin L, Wright DE. Safety of aerobic exercise in people with diabetic peripheral neuropathy: single-group clinical trial. Phys Ther. 2015;95(2):223–34. https://doi.org/10.2522/ptj.20140108. Epub 2014 Oct 2.

    Article  PubMed  Google Scholar 

  • Knauf MT, Koltyn KF. Exercise-induced modulation of pain in adults with and without painful diabetic neuropathy. J Pain. 2014;15(6):656–63. https://doi.org/10.1016/j.jpain.2014.02.008. Epub 2014 Mar 13.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kosek E, Ekholm J, Hansson P. Modulation of pressure pain thresholds during and following isometric contraction in patients with fibromyalgia and in healthy controls. Pain. 1996;64:415–23.

    PubMed  Google Scholar 

  • Koltyn KF, Brellenthin AG, Cook DB, Sehgal N, Hillard C. Mechanisms of exercise-induced hypoalgesia. J Pain. 2014;15(12):1294–304. https://doi.org/10.1016/j.jpain.2014.09.006.

  • Kraemer WJ, Gordon SE, Fleck SJ, Marchitelli LJ, Mello R, Dziados JE, Friedl K, Harman E, Maresh C, Fry AC. Endogenous anabolic hormonal and growth factor responses to heavy resistance exercise in males and females. Int J Sports Med. 1991;12:228–35.

    CAS  PubMed  Google Scholar 

  • Kraemer WJ, Käkkinen K, Triplett-McBride NT, Fry AC, Koziris LP, Ratamess NA, Bauer JE, Volek JS, McConnell T, Newton RU, Gordon SE, Cummings D, Hauth J, Pullo F, Lynch JM, Mazzetti SA, Knuttgen HG. Physiological changes with periodized resistance training in women tenis players. Med Sci Sports Exerc. 2003;35:157–68.

    CAS  PubMed  Google Scholar 

  • Kurtze N, Rangul V, Hustvedt BE, Flanders WD. Reliability and validity of selfreported physical activity in the Nord-Trondelag Health Study: HUNT 1. Scand J Public Health. 2008;36:52–61.

    PubMed  Google Scholar 

  • Landmark T, Romundstad P, Borchgrevink PC, Kaasa S, Dale O. Associations between recreational exercise and chronic pain in the general population: evidence from the HUNT 3 study. Pain. 2011;152(10):2241–7. https://doi.org/10.1016/j.pain.2011.04.029. Epub 2011 May 23.

    Article  PubMed  Google Scholar 

  • Langer N, Hänggi J, Müller NA, Simmen HP, Jäncke L. Effects of limb immobilization on brain plasticity. Neurology. 2012;17. https://doi.org/10.1212/WNL.0b013e31823fcd9c.

  • Lannersten L, Kosek E. Dysfunction of endogenous pain inhibition during exercise with painful muscles in patients with shoulder myalgia and fibromyalgia. Pain. 2010;151:77–86.

    PubMed  Google Scholar 

  • Larsson A, Palstam A, Bjersing J, Löfgren M, Ernberg M, Kosek E, Gerdle B, Mannerkorpi K. Controlled, cross-sectional, multi-center study of physical capacity and associated factors in women with fibromyalgia. BMC Musculoskelet Disord. 2018;19(1):121. https://doi.org/10.1186/s12891-018-2047-1.

    Article  PubMed  PubMed Central  Google Scholar 

  • Larun L, Brurberg KG, Odgaard-Jensen J, Price JR. Exercise therapy for chronic fatigue syndrome. Cochrane Database Syst Rev. 2017;4(4):CD003200. https://doi.org/10.1002/14651858.CD003200.pub7.

    Article  PubMed  Google Scholar 

  • Laube, W. Zur Rückführung des vegetativ-chronotropen Tonus, der Erholung im neuromuskulären System und den Wechselbeziehungen zwischen beiden Funktionssystemen nach Auslösung einer identischen anaeroben Stoffwechselsituation durch verschiedene Belastungsarten. Dissertation B (Dr. med. sc.), Humboldt-Universität zu Berlin, Bereich Medizin Charité, Physiologisches Institut. 1990.

    Google Scholar 

  • Laube W. Physiologie, Leistungsphysiologie, Pathophysiologie und Trainingslehre. In: Hütter-Becker A, Dölken M, Herausgeber. Biomechanik, Bewegungslehre, Leistungsphysiologie, Trainingslehre. Stuttgart/New York: Thieme; 2004. S. 127–319.

    Google Scholar 

  • Laube W, Herausgeber. Sensomotorisches System. Stuttgart/New York: Thieme;2009a.

    Google Scholar 

  • Laube W. Diagnostik der Leistungen des Sensomotorischen Systems: Koordination – Ausdauer – Kraft. In: Laube W, Herausgeber. Sensomotorisches System. Stuttgart/New York: Thieme; 2009b. S. 228–74.

    Google Scholar 

  • Laube W. Physiologie des Zyklus Belastung – Beanspruchung – Ermüdung – Erholung – Adapatation. In: Laube W, Herausgeber. Sensomotorisches System. Stuttgart/New York: Thieme; 2009c. S. 499–555.

    Google Scholar 

  • Laube W. Training der Sensomotorischen Hauptbeanspruchungsformen Koordination, Ausdauer und Kraft. In: Laube W, Herausgeber. Sensomotorisches System. Stuttgart/New York: Thieme; 2009d. S. 556–600. und 617–637.

    Google Scholar 

  • Laube W. Physiologie, Leistungsphysiologie, Pathophysiologie. In: Hütter-Becker A, Dölken M, Herausgeber. Biomechanik, Bewegungslehre, Leistungsphysiologie, Trainingslehre. Stuttgart/New York: Thieme; 2011. S. 129–308.

    Google Scholar 

  • Laube W. Muskelaktivität: Prägung des ZNS und endokrine Funktion – somatische oder degenerativ-nozizeptive Körperstruktur. Man Med. 2013;51:141–50. https://doi.org/10.1007/s00337-012-0989-1.

    Article  Google Scholar 

  • Laube W. Sensorik, sensomotorisches System und Alterungsprozess. in: van den Berg F, Wulf D: Angewandte Physiologie. Bd. 6 Alterungsprozesse und das Alter verstehen. Thieme, Stuttgart-New York, 2008;169–194.

    Google Scholar 

  • Laube W. Sensomotorik und Schmerz. Wechselwirkung von Bewegungsreizen und Schmerzempfinden. Berlin/Heidelberg: Springer;2020.

    Google Scholar 

  • Laube W, Kirste H-J, Jetter H. Fähigkeitsbezogene Funktionsdiagnostik in der orthopädischen Rehabilitation – indikationsgerechte Therapie und Qualitätssicherung. 10. Rehabilitationswissenschaftliches Kolloquium des VdR, Halle/S. DRV Schriften. 2001;26:296–7.

    Google Scholar 

  • Laube W, Kaune M, Pfaff G. Polyneuropathie, Schmerz und Diabetes mellitus Typ II (Teil 4). Orthopädieschuhtechnik – Zeitschrift für Prävention und Rehabilitation. Heft. 2019;3:26–30.

    Google Scholar 

  • Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130(3):456–69. https://doi.org/10.1016/j.cell.2007.05.047.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee JY, Park SJ, Han SA, Lee SH, Koh JM, Hamrick MW, Kim BJ. The effects of myokines on osteoclasts and osteoblasts. Biochem Biophys Res Commun. 2019;517(4):749–54. https://doi.org/10.1016/j.bbrc.2019.07.127. Epub 2019 Aug 5.

    Article  CAS  PubMed  Google Scholar 

  • Leenders M, Verdijk LB, van der Hoeven L, van Kranenburg J, Nilwik R, van Loon LJ. Elderly men and women benefit equally from prolonged resistance-type exercise training. J Gerontol A Biol Sci Med Sci. 2013;68(7):769–79. https://doi.org/10.1093/gerona/gls241. Epub 2012 Dec 7.J Gerontol A Biol Sci Med Sci. 2013. PMID: 23223011.

    Article  PubMed  Google Scholar 

  • Lemley KJ, Hunter SK, Bement MK. Conditioned pain modulation predicts exercise-induced hypoalgesia in healthy adults. Med Sci Sports Exerc. 2015;47(1):176–84. [PubMed: 24870571].

    Google Scholar 

  • Levinger I, Lin X, Zhang X, Brennan-Speranza TC, Volpato B, Hayes A, Jerums G, Seeman E, McConell G. The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo. Osteoporos Int. 2016;27(2):653–63. https://doi.org/10.1007/s00198-015-3273-0. Epub 2015 Aug 11.

    Article  CAS  PubMed  Google Scholar 

  • Lima LV, Abner TSS, Sluka KA. Does exercise increase or decrease pain? Central mechanisms underlying these two phenomena. J Physiol. 2017;595(13):4141–50. https://doi.org/10.1113/JP273355. Epub 2017 May 26.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu DM, Guo XZ, Tong HJ, Tao B, Sun LH, Zhao HY, Ning G, Liu JM. Association between osteocalcin and glucose metabolism: a meta-analysis. Osteoporos Int. 2015;26(12):2823–33. https://doi.org/10.1007/s00198-015-3197-8. Epub 2015 Jun 19.

    Article  CAS  PubMed  Google Scholar 

  • Liu JM, Rosen CJ, Ducy P, Kousteni S, Karsenty G. Regulation of glucose handling by the skeleton: insights from mouse and human studies. Diabetes. 2016;65(11):3225–32. https://doi.org/10.2337/db16-0053.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Löfgren M, Opava CH, Demmelmaier I, Fridén C, Lundberg IE, Nordgren B, Kosek E. Long-term, health-enhancing physical activity is associated with reduction of pain but not pain sensitivity or improved exercise-induced hypoalgesia in persons with rheumatoid arthritis. Arthritis Res Ther. 2018a;20(1):262. https://doi.org/10.1186/s13075-018-1758-x.

    Article  PubMed  PubMed Central  Google Scholar 

  • Löfgren M, Opava CH, Demmelmaier I, Fridén C, Lundberg IE, Nordgren B, Kosek E. Pain sensitivity at rest and during muscle contraction in persons with rheumatoid arthritis: a substudy within the Physical Activity in Rheumatoid Arthritis 2010 study. Arthritis Res Ther. 2018b;20(1):48. https://doi.org/10.1186/s13075-018-1513-3.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lundberg M, Larsson M, Ostlund H, Styf J. Kinesiophobia among patients with musculoskeletal pain in primary healthcare. J Rehabil Med. 2006;38:37–43.

    PubMed  Google Scholar 

  • Macfarlane GJ, Kronisch C, Dean LE, Atzeni F, Häuser W, Fluß E, Choy E, Kosek E, Amris K, Branco J, Dincer F, Leino-Arjas P, Longley K, McCarthy GM, Makri S, Perrot S, Sarzi-Puttini P, Taylor A, Jones GT. EULAR revised recommendations for the management of fibromyalgia. Ann Rheum Dis. 2017;76(2):318–28. https://doi.org/10.1136/annrheumdis-2016-209724. Epub 2016 Jul 4.

    Article  CAS  PubMed  Google Scholar 

  • Massera D, Biggs ML, Walker MD, Mukamal KJ, Ix JH, Djousse L, Valderrábano RJ, Siscovick DS, Tracy RP, Xue X, Kizer JR. Biochemical markers of bone turnover and risk of incident diabetes in older women: the cardiovascular health study. Diabetes Care. 2018;41(9):1901–8. https://doi.org/10.2337/dc18-0849. Epub 2018 Jul 12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mayr U, Kliegl R, Krampe R. Sequential and coordinative processing dynamics in figural transformation across the life span. Cognition. 1996;59:61–90.

    CAS  PubMed  Google Scholar 

  • Mayr U, Spieler DH, Kliegl R. Aging and executive control. New York: Routledge;2001.

    Google Scholar 

  • Meinel K, Schnabel G. Bewegungslehre – Sportmotorik: Abriß einer Theorie der sportlichen Motorik unter pädagogischem Aspekt. 9. Aufl. Berlin: Sportverlag;1998.

    Google Scholar 

  • Mendonça CR, Noll M, Castro MCR, Silveira EA. Effects of nutritional interventions in the control of musculoskeletal pain: an integrative review. Nutrients. 2020;12(10):3075. https://doi.org/10.3390/nu12103075.

    Article  CAS  PubMed Central  Google Scholar 

  • Mengshoel AM, Vollestad NK, Forre O. Pain and fatigue induced by exercise in fibromyalgia patients and sedentary healthy subjects. Clin Exp Rheumatol. 1995;13:477–82. [PubMed: 7586780].

    CAS  PubMed  Google Scholar 

  • Mera P, Laue K, Ferron M, Confavreux C, Wei J, Galán-Díez M, Lacampagne A, Mitchell SJ, Mattison JA, Chen Y, Bacchetta J, Szulc P, Kitsis RN, de Cabo R, Friedman RA, Torsitano C, McGraw TE, Puchowicz M, Kurland I, Karsenty G. Osteocalcin signaling in myofibers is necessary and sufficient for optimum adaptation to exercise. Cell Metab. 2016a;23(6):1078–92. https://doi.org/10.1016/j.cmet.2016.05.004.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mera P, Laue K, Wei J, Berger JM, Karsenty G. Osteocalcin is necessary and sufficient to maintain muscle mass in older mice. Mol Metab. 2016b;5(10):1042–7. https://doi.org/10.1016/j.molmet.2016.07.002. eCollection 2016 Oct.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Messina OD, Vidal Wilman M, Vidal Neira LF. Nutrition, osteoarthritis and cartilage metabolism. Aging Clin Exp Res. 2019;31(6):807–13. https://doi.org/10.1007/s40520-019-01191-w. Epub 2019 Apr 13.

    Article  PubMed  Google Scholar 

  • Mizokami A, Yasutake Y, Gao J, Matsuda M, Takahashi I, Takeuchi H, Hirata M. Osteocalcin induces release of glucagon-like peptide-1 and thereby stimulates insulin secretion in mice. PLoS One. 2013;8(2):e57375. https://doi.org/10.1371/journal.pone.0057375. Epub 2013 Feb 20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Moon HY, Becke A, Berron D, Becker B, Sah N, Benoni G, Janke E, Lubejko ST, Greig NH, Mattison JA, Duzel E, van Praag H. Running-induced systemic Cathepsin B secretion is associated with memory function. Cell Metab. 2016;24(2):332–40. https://doi.org/10.1016/j.cmet.2016.05.025. Epub 2016 Jun 23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Morse CI, Thom JM, Mian OS, Muirhead A, Birch KM, Narici MV. Muscle strength, volume and activation following 12-month resistance training in 70-year-old males. Eur J Appl Physiol. 2005;95:197–204.

    PubMed  Google Scholar 

  • Morton RW, Sato K, Gallaugher MPB, Oikawa SY, McNicholas PD, Fujita S, Phillips SM. Muscle androgen receptor content but not systemic hormones is associated with resistance training-induced skeletal muscle hypertrophy in healthy, Young Men. Front Physiol. 2018;9:1373. https://doi.org/10.3389/fphys.2018.01373. eCollection 2018.

    Article  PubMed  PubMed Central  Google Scholar 

  • Narici MV, Maganaris CN. Adaptability of elderly human muscles and tendons to increased loading. J Anat. 2006;208(4):433–43.

    PubMed  PubMed Central  Google Scholar 

  • Naugle KM, Fillingim RB, Riley JL 3rd. A meta-analytic review of the hypoalgesic effects of exercise. J Pain. 2012;13(12):1139–50. https://doi.org/10.1016/j.jpain.2012.09.006. Epub 2012 Nov 8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Naugle KM, Cruz-Almeida Y, Fillingim RB, Riley JL 3rd. Offset Analgesia Is Reduced in Older Adults. Pain. 2013;154(11):2381–7.

    Google Scholar 

  • Naugle KM, Naugle KE, Fillingim RB, Riley JL 3rd. Isometric exercise as a test of pain modulation: effects of experimental pain test, psychological variables, and sex. Pain Med. 2014;15(4):692–701.

    PubMed  Google Scholar 

  • Naugle KM, Cruz-Almeida Y, Vierck CJ, Mauderli AP, Riley JL 3rd. Age-related differences in conditioned pain modulation of sensitizing and desensitizing trends during response dependent stimulation. Behav Brain Res. 2015;289:61–8.

    PubMed  PubMed Central  Google Scholar 

  • Naugle KM, Naugle KE, Riley JL 3rd. Reduced modulation of pain in older adults after isometric and aerobic exercise. J Pain. 2016;17(6):719–28. https://doi.org/10.1016/j.jpain.2016.02.013. Epub 2016 Mar 15.

    Article  PubMed  PubMed Central  Google Scholar 

  • Naugle KM, Ohlman T, Wind B, Miller L. Test-retest instability of temporal summation and conditioned pain modulation measures in older adults. Pain Med. 2020;21(11):2863–76. https://doi.org/10.1093/pm/pnaa288. Online ahead of print.

    Article  PubMed  Google Scholar 

  • Newcomb LW, Koltyn KF, Morgan WP, Cook DB. Influence of preferred versus prescribed exercise on pain in fibromyalgia. Med Sci Sports Exerc. 2011;43:1106–13.

    PubMed  PubMed Central  Google Scholar 

  • Nindl BC, Pierce JR. Insulin-like growth factor I as a biomarker of health, fitness, and training status. Med Sci Sports Exerc. 2010;42:39–49. https://doi.org/10.1249/MSS.0b013e3181b07c4d.

    Article  CAS  PubMed  Google Scholar 

  • Nudo RJ, Williken GW, Jenkins WM, Merzenich MM. Use-dependent alterations of movement representations in primary motor cortex of adult squirrel monkeys. J Neurosci. 1996;15:785–807.

    Google Scholar 

  • OARSI (Osteoarthritis Research Society International). Non-surgical management of knee osteoarthritis, March 4, 2014 Patient Summary. https://oarsi.org/sites/default/files/library/2014/pdf/patientsumfinal.pdf.

  • Okita M, Yoshimura T, Nakano J, Motomura M, Eguchi K. Effects of reduced joint mobility on sarcomere length, collagen fibril arrangement in the endomysium, and hyaluronan in rat soleus muscle. J Muscle Res Cell Motil. 2004;25(2):159–66. https://doi.org/10.1023/b:jure.0000035851.12800.39.

    Article  CAS  PubMed  Google Scholar 

  • Oury F, Sumara G, Sumara O, Ferron M, Chang H, Smith CE, Hermo L, Suarez S, Roth BL, Ducy P, Karsenty G. Endocrine regulation of male fertility by the skeleton. Cell. 2011;144(5):796–809. https://doi.org/10.1016/j.cell.2011.02.004. Epub 2011 Feb 17.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Oury F, Ferron M, Huizhen W, Confavreux C, Xu L, Lacombe J, Srinivas P, Chamouni A, Lugani F, Lejeune H, Kumar TR, Plotton I, Karsenty G. Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. J Clin Invest. 2013a;123(6):2421–33.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Oury F, Khrimian L, Denny CA, Gardin A, Chamouni A, Goeden N, Huang YY, Lee H, Srinivas P, Gao XB, Suyama S, Langer T, Mann JJ, Horvath TL, Bonnin A, Karsenty G. Maternal and offspring pools of osteocalcin influence brain development and functions. Cell. 2013b;155(1):228–41. https://doi.org/10.1016/j.cell.2013.08.042.

    Article  CAS  PubMed  Google Scholar 

  • Parkhouse N, Le Quesne PM. Impaired neurogenic vascular response in patients with diabetic and neuropathic foot lesions. New Engl J Med. 1988;318:1306–9.

    CAS  PubMed  Google Scholar 

  • Pattwell DM, Jackson MJ. Contraction-induced oxidants as mediators of adaptation and damage in skeletal muscle. Exerc Sport Sci Rev. 2004;32(1):14–8.

    PubMed  Google Scholar 

  • Paulsen G, Mikkelsen UR, Raastad T, Peake JM. Leucocytes, cytokines and satellite cells: what role do they play in muscle, damage and regeneration following eccentric exercise? Exerc Immunol Rev. 2012;18:42–97.

    PubMed  Google Scholar 

  • Pedersen BK. The diseasome of physical inactivity and the role of myokines in muscle-fat cross talk. J Physiol. 2009;587:5559–68.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Pedersen BK. Physical activity and muscle-brain crosstalk. Nat Rev Endocrinol. 2019;15(7):383–92. https://doi.org/10.1038/s41574-019-0174-x.

    Article  PubMed  Google Scholar 

  • Pedersen BK, Saltin B. Exercise as medicine—evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports. 2015;25(suppl 3):1–72.

    PubMed  Google Scholar 

  • Petersson S, Philippou E, Rodomar C, Nikiphorou E. The Mediterranean diet, fish oil supplements and Rheumatoid arthritis outcomes: evidence from clinical trials. Autoimmun Rev. 2018;17(11):1105–14. https://doi.org/10.1016/j.autrev.2018.06.007. Epub 2018 Sep 10.

    Article  CAS  PubMed  Google Scholar 

  • Picavet HS, Hazes JM. Prevalence of self-reported musculoskeletal diseases is high. Ann Rheum Di. 2003;62:644–50.

    CAS  Google Scholar 

  • Pimentel AE, Gentile CL, Tanaka H, Seals DR, Gates PE. Greater rate of decline in maximal aerobic capacity with age in endurance-trained than in sedentary men. J Appl Physiol. 2003;94(6):2406–13. Epub 2003 Jan 17.

    PubMed  Google Scholar 

  • Pittas AG, Roberts SB, Das SK, Gilhooly CH, Saltzman E, Golden J, Stark PC, Greenberg AS. The effects of the dietary glycemic load on type 2 diabetes risk factors during weight loss. Obesity (Silver Spring). 2006;14(12):2200–9. https://doi.org/10.1038/oby.2006.258.

    Article  CAS  Google Scholar 

  • Poole CA, Flint MH, Beaumont BW. Chondrons in cartilage: ultrastructural analysis of the pericellular microenvironment in adult human articular cartilages. J Orthop Res. 1987;5(4):509–22. https://doi.org/10.1002/jor.1100050406.

    Article  CAS  PubMed  Google Scholar 

  • Powers SK, Kavazis AN, McClung JM. Oxidative stress and disuse muscle atrophy. J Appl Physiol. 2007;102(6):2389–97. Epub 2007 Feb 8.

    CAS  PubMed  Google Scholar 

  • Powers SK, Smuder AJ, Criswell DS. Mechanistic links between oxidative stress and disuse muscle atrophy. Antioxid Redox Signal. 2011;15(9):2519–28. https://doi.org/10.1089/ars.2011.3973. Epub 2011 Jun 17.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pritzlaff CJ, Wideman L, Weltman JY, Abbott RD, Gutgesell ME, Hartman ML, Veldhuis JD, Weltman A. Impact of acute exercise intensity on pulsatile growth hormone release in men. J Appl Physiol. 1999;87:498–504.

    CAS  PubMed  Google Scholar 

  • Rathore A, Lom B. The effects of chronic and acute physical activity on working memory performance in healthy participants: a systematic review with meta-analysis of randomized controlled trials. Syst Rev. 2017;6(1):124. https://doi.org/10.1186/s13643-017-0514-7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Reijmer YD, Leemans A, Brundel M, Kappelle LJ, Biessels GJ. Utrecht Vascular Cognitive Impairment Study Group: disruption of the cerebral white matter network is related to slowing of information processing speed in patients with type 2 diabetes. Diabetes. 2013;62(6):2112–5. https://doi.org/10.2337/db12-1644. Epub 2013 Jan 24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rice D, Nijs J, Kosek E, Wideman T, Hasenbring MI, Koltyn K, Graven-Nielsen T, Polli A. Exercise-induced hypoalgesia in pain-free and chronic pain populations: state of the art and future directions. J Pain. 2019;20(11):1249–66. https://doi.org/10.1016/j.jpain.2019.03.005. Epub 2019 Mar 21.

    Article  PubMed  Google Scholar 

  • Riley JL, King CD, Wong F, Fillingim RB, Mauderli AP. Lack of endogenous modulation and reduced decay of prolonged heat pain in older adults. Pain. 2010;150:153–60.

    PubMed  PubMed Central  Google Scholar 

  • Rioult-Pedotti MS, Friedman D, Donoghue JP. Learning induced LTP in neocortex. Science. 2000;290:533–6.

    CAS  PubMed  Google Scholar 

  • Rondanelli M, Faliva MA, Miccono A, Naso M, Nichetti M, Riva A, Guerriero F, De Gregori M, Peroni G, Perna S. Food pyramid for subjects with chronic pain: foods and dietary constituents as anti-inflammatory and antioxidant agents. Nutr Res Rev. 2018;31(1):131–51. https://doi.org/10.1017/S0954422417000270. Epub 2018 Apr 22.

    Article  CAS  PubMed  Google Scholar 

  • Rondanelli M, Miraglia N, Putignano P, Peroni G, Faliva MA, Naso M, Gasparri C, Infantino V, Nichetti M, Volpi N, Capitani F, Mantovani V, Perna S. Short- and long-term effectiveness of supplementation with non-animal chondroitin sulphate on inflammation, oxidative stress and functional status in obese subjects with moderate knee osteoarthritis before and after physical stress: a randomized, double-blind, Placebo-controlled trial. Antioxidants (Basel). 2020;9(12):1241. https://doi.org/10.3390/antiox9121241.

    Article  CAS  Google Scholar 

  • Safdar A, Hamadeh MJ, Kaczor JJ, Raha S, Debeer J, Tarnopolsky MA. Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults. PLoS One. 2010;5(5):e10778. https://doi.org/10.1371/journal.pone.0010778.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Salthouse TA. The processing-speed theory of adult age differences in cognition. Psychol Rev. 1996;103:403–28.

    CAS  PubMed  Google Scholar 

  • Sandal LF, Roos EM, Bøgesvang SJ, Thorlund JB. Pain trajectory and exercise-induced pain flares during 8 weeks of neuromuscular exercise in individuals with knee and hip pain. Osteoarthr Cartil. 2016;24(4):589–92. https://doi.org/10.1016/j.joca.2015.11.002. Epub 2015 Nov 10.

    Article  CAS  Google Scholar 

  • Santini A, Tenore GC, Novellino E. Nutraceuticals: a paradigm of proactive medicine. Eur J Pharm Sci. 2017;96:53–61.

    CAS  PubMed  Google Scholar 

  • Sato K, Iemitsu M. Exercise and sex steroid hormones in skeletal muscle. J Steroid Biochem Mol Biol. 2015;145:200–5. https://doi.org/10.1016/j.jsbmb.2014.03.009. Epub 2014 Apr 3.

    Article  CAS  PubMed  Google Scholar 

  • Scheele C, Nielsen S, Pedersen BK. ROS and myokines promote muscle adaptation to exercise. Trends Endocrinol Metab. 2009;20(3):95–9. Epub 2009 Mar 9.

    CAS  PubMed  Google Scholar 

  • Scudds RJ, McD Robertson J. Empirical evidence of the association between the presence of musculoskeletal pain and physical disability in community-dwelling senior citizens. Pain. 1998;75:229–35.

    CAS  PubMed  Google Scholar 

  • Seaman DR. The diet-induced proinflammatory state: a cause of chronic pain and other degenerative diseases? J Manipulative Physiol Ther. 2002;25:168–79.

    PubMed  Google Scholar 

  • Shan C, Ghosh A, Guo XZ, Wang SM, Hou YF, Li ST, Liu JM. Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders. Mol Brain. 2019;12(1):23. https://doi.org/10.1186/s13041-019-0444-5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shen J, Fox LE, Cheng J. Swim therapy reduces mechanical allodynia and thermal hyperalgesia induced by chronic constriction nerve injury in rats. Pain Med. 2013;14:516–25.

    PubMed  Google Scholar 

  • Shipton EA. Physical therapy approaches in the treatment of low back pain. Pain Ther. 2018;7(2):127–37. https://doi.org/10.1007/s40122-018-0105-x. Epub 2018 Sep 18.

    Article  PubMed  PubMed Central  Google Scholar 

  • Singh JA, Noorbaloochi S, MacDonald R, Maxwell LJ. Chondroitin for osteoarthritis. Cochrane Database Syst Rev. 2015;1:CD005614. https://doi.org/10.1002/14651858.CD005614.pub2.

    Article  PubMed  Google Scholar 

  • Skelly AC, Chou R, Dettori JR, Turner JA, Friedly JL, Rundell SD, Fu R, Brodt ED, Wasson N, Winter C, Ferguson AJR. Noninvasive nonpharmacological treatment for chronic pain: a systematic review [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2018 Jun. Report No.: 18-EHC013-EF. AHRQ Comparative Effectiveness Reviews.

    Google Scholar 

  • Skou ST, Roos EM, Laursen MB, Rathleff MS, Arendt-Nielsen L, Simonsen OH, Rasmussen S. Total knee replacement plus physical and medical therapy or treatment with physical and medical therapy alone: a randomised controlled trial in patients with knee osteoarthritis (The MEDIC-study). BMC Musculoskelet Disord. 2012;13:67.

    PubMed  PubMed Central  Google Scholar 

  • Skou ST, Roos EM, Laursen MB, Rathleff MS, Arendt-Nielsen L, Simonsen O, Rasmussen S. A randomized, controlled trial of total knee replacement. N Engl J Med. 2015;373:1597–606. https://doi.org/10.1056/NEJMoa1505467.

    Article  CAS  PubMed  Google Scholar 

  • Smilios I, Pilianidis T, Karamouzis M, Tokmakidis SP. Hormonal responses after various resistance exercise protocols. Med Sci Sports Exerc. 2003;35:644–54.

    CAS  PubMed  Google Scholar 

  • Smith PJ, Blumenthal JA, Hoffman BM, Cooper H, Strauman TA, Welsh-Bohmer K, Browndyke JN, Sherwood A. Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom Med. 2010;72(3):239–52. https://doi.org/10.1097/PSY.0b013e3181d14633. Epub 2010 Mar 11.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sohal RS, Forster MJ. Caloric restriction and the aging process: a critique. Free Radic Biol Med. 2014;73:366–82. https://doi.org/10.1016/j.freeradbiomed.2014.05.015. Epub 2014 Jun 2.

    Article  CAS  PubMed  Google Scholar 

  • Sokoloff AJ, Siegel SG, Cope TC. Recruitment order among motoneurons from different motor nuclei. J Neurophysiol. 1999;81:2485–92.

    CAS  PubMed  Google Scholar 

  • Srikuea R, Symons TB, Long DE, Lee JD, Shang Y, Chomentowski PJ, Yu G, Crofford LJ, Peterson CA. Association of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women. Arthritis Rheum. 2013;65(2):519–28. https://doi.org/10.1002/art.37763.

    Article  PubMed  PubMed Central  Google Scholar 

  • Stamatakis E, Hamer M, O’Donovan G, Batty GD, Kivimaki M. A non-exercise testing method for estimating cardiorespiratory fitness: associations with all-cause and cardiovascular mortality in a pooled analysis of eight population-based cohorts. Eur Heart J. 2013;34(10):750–8. https://doi.org/10.1093/eurheartj/ehs097. Epub 2012 May 3.

    Article  PubMed  Google Scholar 

  • Staud R, Robinson ME, Price DD. Isometric exercise has opposite effects on central pain mechanisms in fibromyalgia patients compared to normal controls. Pain. 2005;118:176–84.

    PubMed  Google Scholar 

  • Staud R, Robinson ME, Weyl EE, Price DD. Pain variability in fibromyalgia is related to activity and rest: role of peripheral tissue impulse input. J Pain. 2010;11(12):1376–83.

    PubMed  PubMed Central  Google Scholar 

  • Stavropoulos-Kalinoglou A, Metsios GS, Veldhuijzen van Zanten JJ, Nightingale P, Kitas GD, Koutedakis Y. Individualised aerobic and resistance exercise training improves cardiorespiratory fitness and reduces cardiovascular risk in patients with rheumatoid arthritis. Ann Rheum Dis. 2013;72(11):1819–25. https://doi.org/10.1136/annrheumdis-2012-202075. Epub 2012 Nov 15.Ann Rheum Dis. 2013. PMID: 23155222.

    Article  CAS  PubMed  Google Scholar 

  • Steinberg H, Sykes EA, Moss T, Lowery S, LeBoutillier N, Dewey A. Exercise enhances creativity independently of mood. Br J Sports Med. 1997;31(3):240–5. https://doi.org/10.1136/bjsm.31.3.240.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Suga N, Xiao Z, Ma X, Ji W. Plasticity and cortifugal modulation for hearing in adult animals. Neuron. 2002;36:9–18.

    CAS  PubMed  Google Scholar 

  • Sullivan EV, Pfefferbaum A. Diffusion tensor imaging and aging. Neurosci Biobehav Rev. 2006;30:749–61.

    PubMed  Google Scholar 

  • Swain DP, Abernathy KS, Smith CS, Lee SJ, Bunn SA. Target heart rates for the development of cardiorespiratory fitness. Med Sci Sports Exerc. 1994;26:112–6.

    CAS  PubMed  Google Scholar 

  • Swain RA, Harris AB, Wiener EC, Dutka MV, Morris HD, Theien BE, Konda S, Engberg K, Lauterbur PC, Greenough WT. Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat. Neuroscience. 2003;117:1037–46.

    CAS  PubMed  Google Scholar 

  • Tanaka H, Seals DR. Invited Review: Dynamic exercise performance in Masters athletes: insight into the effects of primary human aging on physiological functional capacity. J Appl Physiol. 2003;95(5):2152–62.

    PubMed  Google Scholar 

  • Tanaka H, Seals DR. Endurance exercise performance in Masters athletes: age-associated changes and underlying physiological mechanisms. J Physiol. 2008;586(1):55–63. Epub 2007 Aug 23.

    CAS  PubMed  Google Scholar 

  • Torebjork HE, Hallin RG. Identification of afferent C units in intact human skin nerves. Brain Res. 1974;67:387–403.

    CAS  PubMed  Google Scholar 

  • Tour J, Löfgren M, Mannerkorpi K, Gerdle B, Larsson A, Palstam A, Bileviciute-Ljungar I, Bjersing J, Martin I, Ernberg M, Schalling M, Kosek E. Gene-to-gene interactions regulate endogenous pain modulation in fibromyalgia patients and healthy controls-antagonistic effects between opioid and serotonin-related genes. Pain. Jul 2017;158(7):1194–203.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Tudor-Locke C, Bassett DR Jr. How many steps/day are enough? Preliminary pedometer indices for public health. Sports Med. 2004;34:1–8.

    PubMed  Google Scholar 

  • Turrina A, Martínez-González MA, Stecco C. The muscular force transmission system: role of the intramuscular connective tissue. J Bodyw Mov Ther. 2013;17(1):95–102. https://doi.org/10.1016/j.jbmt.2012.06.001. Epub 2012 Jul 4.

    Article  PubMed  Google Scholar 

  • Tweedie C, Romestaing C, Burelle Y, Safdar A, Tarnopolsky MA, Seadon S, Britton SL, Koch LG, Hepple RT. Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity. Am J Phys Regul Integr Comp Phys. 2011;300(3):R544–53. Epub 2010 Dec 9.

    CAS  Google Scholar 

  • Vaegter HB, Handberg G, Graven-Nielsen T. Hypoalgesia after exercise and the cold pressor test is reduced in chronic musculoskeletal pain patients with high pain sensitivity. Clin J Pain. 2016;32(1):58–69.

    PubMed  Google Scholar 

  • Vaegter HB, Handberg G, Emmeluth C, Graven-Nielsen T. Preoperative hypoalgesia after cold pressor test and aerobic exercise is associated with pain relief 6 months after total knee replacement. Clin J Pain. 2017;33(6):475–84. https://doi.org/10.1097/AJP.0000000000000428.

    Article  PubMed  Google Scholar 

  • Vaegter HB, Madsen AB, Handberg G, Graven-Nielsen T. Kinesiophobia is associated with pain intensity but not pain sensitivity before and after exercise: an explorative analysis. Physiotherapy. 2018;104(2):187–93.

    CAS  PubMed  Google Scholar 

  • Veldhuis JD, Iranmanesh A, Weltman A. Elements in the pathophysiology of diminished growth hormone (GH) secretion in aging humans. Endocrine. 1997;7(1):41–8.

    CAS  PubMed  Google Scholar 

  • Vierck CJ, Cannon RL, Fry G, Maixner W, Whitsel BL. Characteristics of temporal summation of second pain sensations elicited but brief contact of glaborous skin by a preheated probe. J Neurophysiol. 1997;78:992–1002. [PubMed: 9307129].

    PubMed  Google Scholar 

  • Vierck CJ, Whitsel BL, Favorov OV, Brown AW, Tommerdahl M. Role of primary somatosensory cortex in the coding of pain. Pain. 2013;154:334–44. [PubMed: 23245864].

    PubMed  Google Scholar 

  • Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo FM, Wyss-Coray T. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med. 2014;20(6):659–63. https://doi.org/10.1038/nm.3569. Epub 2014 May 4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vincent KR, Braith RW, Feldman RA, Magyari PM, Cutler RB, Persin SA, Lennon SL, Gabr AH, Lowenthal DT. Resistance exercise and physical performance in adults aged 60–83 years. J Am Geriatr Soc. 2002;50:1100–7.

    Google Scholar 

  • Vingren JL, Kraemer WJ, Hatfield DL, Anderson JM, Volek JS, Ratamess NA, Thomas GA, Ho JY, Fragala MS, Maresh CM. Effect of resistance exercise on muscle steroidogenesis. J Appl Physiol. 2008;105:1754–60. https://doi.org/10.1152/japplphysiol.91235.2008.

    Article  PubMed  Google Scholar 

  • Volkert D, Berner YN, Berry E, Cederholm T, Coti Bertrand P, Milne A, Palmblad J, Schneider S, Sobotka L, Stanga Z, DGEM (German Society for Nutritional Medicine), Lenzen-Grossimlinghaus R, Krys U, Pirlich M, Herbst B, Schütz T, Schröer W, Weinrebe W, Ockenga J, Lochs H, ESPEN (European Society for Parenteral and Enteral Nutrition). ESPEN guidelines on enteral nutrition: geriatrics. Clin Nutr. 2006;25(2):330–60. https://doi.org/10.1016/j.clnu.2006.01.012.

    Article  CAS  PubMed  Google Scholar 

  • Wei J, Karsenty G. An overview of the metabolic functions of osteocalcin. Rev Endocr Metab Disord. 2015;16:93–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  • West R. An application of prefrontal cortex function theory to cognitive aging. Psychol Bull. 1996;120:272–92.

    CAS  PubMed  Google Scholar 

  • Westcott WL. Resistance training is medicine: effects of strength training on health. Curr Sports Med Rep. 2012;11:209–16.

    PubMed  Google Scholar 

  • Wilder J. „Ausgangswert-Gesetz“ – Ein unbeachtetes Gesetz, seine Bedeutung für Forschung und Praxis. Klin Wschr. 1931;10:1189–94.

    Google Scholar 

  • Whitlock EL, Diaz-Ramirez LG, Glymour MM, Boscardin WJ, Covinsky KE, Smith AK. Association between persistent pain and memory decline and dementia in a longitudinal cohort of elders. JAMA Intern Med. 2017;177(8):1146–53. https://doi.org/10.1001/jamainternmed.2017.1622.

    Article  PubMed  PubMed Central  Google Scholar 

  • WHO. Diet, nutrition, and the prevention of chronic diseases: report of a joint WHO/FAO expert consultation, Bd. 916. Geneva, Switzerland: World Health Organization;2003.

    Google Scholar 

  • Wolff J. Das Gesetz der Transformation der Knochen. Berlin: Hirschwald;1892.

    Google Scholar 

  • World Health Organization. Global recommendations on physical activity for health. 1. Exercise. 2. Life style. 3. Health promotion. 4. Chronic disease – prevention and control. 5. National health programs. 2011.

    Google Scholar 

  • Wylde V, Dieppe P, Hewlett S, Learmonth ID. Total knee replacement: is it really an effective procedure for all? Knee. 2007;14(6):417–23.

    CAS  PubMed  Google Scholar 

  • Yeap BB, Alfonso H, Chubb SA, Gauci R, Byrnes E, Beilby JP, Ebeling PR, Handelsman DJ, Allan CA, Grossmann M, Norman PE, Flicker L. Higher serum undercarboxylated osteocalcin and other bone turnover markers are associated with reduced diabetes risk and lower estradiol concentrations in older men. J Clin Endocrinol Metab. 2015;100(1):63–71. https://doi.org/10.1210/jc.2014-3019.

    Article  CAS  PubMed  Google Scholar 

  • Yoo M, D’Silva LJ, Martin K, Sharma NK, Pasnoor M, LeMaster JW, Kluding PM. Pilot study of exercise therapy on painful diabetic peripheral neuropathy. Pain Med. 2015;16(8):1482–9. https://doi.org/10.1111/pme.12743. Epub 2015 Mar 20.

    Article  PubMed  Google Scholar 

  • Zaletel I, Filipović D, Puškaš N. Hippocampal BDNF in physiological conditions and social isolation. Rev Neurosci. 2017;28(6):675–92. https://doi.org/10.1515/revneuro-2016-0072.

    Article  CAS  PubMed  Google Scholar 

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  1. Department für Orthopädie, Unfall- und Wiederherstellungschirurgie, Martin-Luther-Universität Halle-Wittenberg, Halle-Wittenberg, Deutschland

    Wolfgang Laube

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Laube, W. (2022). Die aktiven Bausteine der Regulativen Schmerzbehandlung – langfristige anti-nozizeptive periphere und zentrale Reorganisation mit integrierter Qualifizierung der Schmerztoleranz und Schmerzhemmung. In: Schmerztherapie ohne Medikamente. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-63846-0_12

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