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Cannabinoide

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Pädiatrische Palliativversorgung – Schmerzbehandlung und Symptomkontrolle

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Zusammenfassung

Mit dem im Januar 2017 vom deutschen Bundestag beschlossenen Gesetz zur Änderung betäubungsmittelrechtlicher und anderer Vorschriften wurde die Möglichkeit zur Verwendung von Cannabisarzneimitteln deutlich erweitert. Bereits zugelassene Cannabisarzneimittel können im Einzelfall außerhalb der zugelassenen Indikation zu Lasten der gesetzlichen Krankenkasse verschrieben werden. Auch für die nicht arzneimittelrechtlich zugelassenen Cannabisblüten und -extrakte sowie Dronabinol (THC) werden auf Antrag die Kosten übernommen. Grund genug, diese neue Therapieoption näher kennenzulernen. Das Kapitel stellt die wichtigsten Cannabinoide vor und gibt einen detaillierten Überblick über deren Anwendungsgebiete und Wirkungsweisen.

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Literatur

  • Anderson VA, Anderson P, Northam E et al (2001) Development of executive functions through late childhood and adolescence in an Australian sample. Dev Neuropsychol 20(1):385–406

    Article  CAS  PubMed  Google Scholar 

  • Arellano AL, Papaseit E, Romaguera A et al (2017) Neuropsychiatric and general interactions of natural and synthetic cannabinoids with drugs of abuse and medicines. CNS Neurol Disord Drug Targets 16(5):554–566

    Article  CAS  PubMed  Google Scholar 

  • Arseneault L, Cannon M, Poulton R et al (2002) Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study. Br Med J 325(7374):1212–1213

    Article  Google Scholar 

  • Barchel D, Stolar O, De-Haan T et al (2019) Oral cannabidiol use in children with autism spectrum disorder to treat related symptoms and co-morbidities. Front Pharmacol 9:1521

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bechtold J, Hipwell A, Lewis DA et al (2016) Concurrent and sustained cumulative effects of adolescent marijuana use on subclinical psychotic symptoms. Am J Psychiatry 173(8):781–789

    Article  PubMed  PubMed Central  Google Scholar 

  • Blakemore S-J (2013) Teenage kicks: cannabis and the adolescent brain. Lancet 9870(381):888–889

    Article  Google Scholar 

  • Bundesministerium der Justiz und für Verbraucherschutz, Bundesamt für Justiz (2019) „Das Fünfte Buch Sozialgesetzbuch – Gesetzliche Krankenversicherung – (Artikel 1 des Gesetzes vom 20. Dezember 1988, BGBl. I S. 2477, 2482), das zuletzt durch Artikel 1 des Gesetzes vom 21. Dezember 2019 (BGBl. I S. 2913) geändert worden ist“. https://www.gesetze-im-internet.de/sgb_5/BJNR024820988.html. Zugegriffen am 01.02.2020

  • Burns HD, Van Laere K, Sanabria-Bohórquez S et al (2007) [18F] MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor. Proc Natl Acad Sci USA 104(23):9800–9805

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chan HS, Correia JA, MacLeod SM (1987) Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children: a double-blind, crossover trial. Pediatrics 79(6):946–952

    CAS  PubMed  Google Scholar 

  • Claudet I, Le Breton M, Bréhin C et al (2017) A 10-year review of cannabis exposure in children under 3-years of age: do we need a more global approach? Eur J Pediatr 176(4):553–556

    Article  PubMed  Google Scholar 

  • Cremer-Schaeffer P, Schmidt-Wolf G, Broich K (2019) Cannabisarzneimittel in der Schmerztherapie. Schmerz 33(5):415–423

    Article  CAS  PubMed  Google Scholar 

  • Dalzell A, Bartlett H, Lilleyman J (1986) Nabilone: an alternative antiemetic for cancer chemotherapy. Arch Dis Child 61(5):502–505

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Devinsky O, Cross JH, Laux L et al (2017) Trial of cannabidiol for drug-resistant seizures in the Dravet syndrome. N Engl J Med 376(21):2011–2020

    Article  CAS  PubMed  Google Scholar 

  • Ekert H, Waters K, Jurk I et al (1979) Amelioration of cancer hemotherapyinduced nausea and vomiting by delta-9-tetrahydrocannabinol. Med J Austral 2(12):657–659

    Article  CAS  PubMed  Google Scholar 

  • Elder JJ, Knoderer HM (2015) Characterization of dronabinol usage in a pediatric oncology population. J Pediatr Pharmacol Ther 20(6):462–467

    PubMed  PubMed Central  Google Scholar 

  • Elliott J, DeJean D, Clifford T et al (2019) Cannabis-based products for pediatric epilepsy: a systematic review. Epilepsia 60(1):6–19

    Article  PubMed  Google Scholar 

  • George T, Vaccarino F (2015) Substance abuse in Canada: the effects of cannabis use during adolescence. https://www.ccsa.ca/sites/default/files/2019-04/CCSA-Effects-of-Cannabis-Use-during-Adolescence-Report-2015-en.pdf. Zugegriffen am 01.02.2020

  • Giedd JN, Blumenthal J, Jeffries NO et al (1999) Brain development during childhood and adolescence: a longitudinal MRI study. Nat Neurosci 2(10):861–863

    Article  CAS  PubMed  Google Scholar 

  • Gilman JM, Kuster JK, Lee S et al (2014) Cannabis use is quantitatively associated with nucleus accumbens and amygdala abnormalities in young adult recreational users. J Neurosci 34(16):5529–5538

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hadland SE, Harris SK (2014) Youth marijuana use: state of the science for the practicing clinician. Curr Opin Pediatr 26(4):420–427

    Article  PubMed  PubMed Central  Google Scholar 

  • Hasan A, Rothenberger A, Münchau A et al (2010) Oral Δ9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: a case report. J Clin Psychopharmacol 30(2):190–192

    Article  PubMed  Google Scholar 

  • Häuser W, Welsch P, Klose P et al (2019) Efficacy, tolerability and safety of cannabis-based medicines for cancer pain. Schmerz 33(5):424–436

    Article  PubMed  Google Scholar 

  • Hoch E, Friemel CM, Schneider M (2019) Cannabis: Potenzial und Risiko- Eine wissenschaftliche Bestandsaufnahme. https://www.bundesgesundheitsministerium.de/fileadmin/Dateien/5_Publikationen/Drogen_und_Sucht/Berichte/Hoch_et_al_Cannabis_Potential_u_Risiko_SS.pdf. Zugegriffen am 01.02.2020

  • Hurd YL, Michaelides M, Miller ML et al (2014) Trajectory of adolescent cannabis use on addiction vulnerability. Neuropharmacology 76:416–424

    Article  CAS  PubMed  Google Scholar 

  • Jacobsen LK, Mencl WE, Westerveld M et al (2004) Impact of cannabis use on brain function in adolescents. Ann N Y Acad Sci 1021(1):384–390

    Article  PubMed  Google Scholar 

  • Jacobsen LK, Pugh KR, Constable RT et al (2007) Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent cannabis users. Biol Psychiatry 61(1):31–40

    Article  CAS  PubMed  Google Scholar 

  • Kuhlen M, Hoell JI, Gagnon G et al (2016) Effective treatment of spasticity using dronabinol in pediatric palliative care. Eur J Paediatr Neurol 20(6):898–903

    Article  PubMed  Google Scholar 

  • Lenroot RK, Giedd JN (2006) Brain development in children and adolescents: insights from anatomical magnetic resonance imaging. Neurosci Biobehav Rev 30(6):718–729

    Article  PubMed  Google Scholar 

  • Lisdahl KM, Wright NE, Medina-Kirchner C et al (2014) Considering cannabis: the effects of regular cannabis use on neurocognition in adolescents and young adults. Curr Addict Rep 1(2):144–156

    Article  PubMed  PubMed Central  Google Scholar 

  • Mechoulam R, Parker LA (2013) The endocannabinoid system and the brain. Annu Rev Psychol 64(1):21–47

    Article  PubMed  Google Scholar 

  • Medina KL, McQueeny T, Nagel BJ et al (2009) Prefrontal cortex morphometry in abstinent adolescent marijuana users: subtle gender effects. Addict Biol 14(4):457–468

    Article  PubMed  PubMed Central  Google Scholar 

  • Mendiguren A, Aostri E, Pineda J (2018) Regulation of noradrenergic and serotonergic systems by cannabinoids: relevance to cannabinoid-induced effects. Life Sci 192:115–127

    Article  CAS  PubMed  Google Scholar 

  • Mücke M, Phillips T, Radbruch L et al. (2018a) Cannabis-based medicines for chronic neuropathic pain in adults (Review). Cochrane Database Syst Rev (3):Cd012182

    Google Scholar 

  • Mücke M, Weier M, Carter C et al (2018b) Systematic review and meta-analysis of cannabinoids in palliative medicine. J Cachexia Sarcopenia Muscle 9(2):220–234

    Article  PubMed  PubMed Central  Google Scholar 

  • Nguyen-Louie TT, Castro N, Matt GE et al (2015) Effects of emerging alcohol and marijuana use behaviors on adolescents’ neuropsychological functioning over four years. J Stud Alcohol Drugs 76(5):738–748

    Article  PubMed  PubMed Central  Google Scholar 

  • Nielsen S, Murnion B, Campbell G et al (2019) Cannabinoids for the treatment of spasticity. Dev Med Child Neurol 61(6):631–638

    Article  PubMed  Google Scholar 

  • Petzke F, Karst M, Gastmeier K et al (2019) Ein Positionspapier zu medizinischem Cannabis und cannabisbasierten Medikamenten in der Schmerzmedizin. Schmerz 33(5):449–465

    Article  PubMed  Google Scholar 

  • Piazza PV, Cota D, Marsicano G (2017) The CB1 receptor as the cornerstone of exostasis. Neuron 93(6):1252–1274

    Article  CAS  PubMed  Google Scholar 

  • Shannon S, Opila-Lehman J (2016) Effectiveness of cannabidiol oil for pediatric anxiety and insomnia as part of posttraumatic stress disorder: a case report. Perm J 20(4):16–005

    Article  PubMed  PubMed Central  Google Scholar 

  • Smith LA, Azariah F, Lavender VT et al. (2015) Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy. Cochrane Database Syst Rev (11):CD009464.pub2

    Google Scholar 

  • Solowij N, Jones KA, Rozman ME et al (2011) Verbal learning and memory in adolescent cannabis users, alcohol users and non-users. Psychopharmacology 216(1):131–144

    Article  CAS  PubMed  Google Scholar 

  • Stockings E, Campbell G, Hall WD et al (2018) Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta-analysis of controlled and observational studies. Pain 159(10):1932–1954

    Article  CAS  PubMed  Google Scholar 

  • Stout SM, Cimino NM (2014) Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review. Drug Metab Rev 46(1):86–95

    Article  CAS  PubMed  Google Scholar 

  • Tapert SF, Granholm E, Leedy NG et al (2002) Substance use and withdrawal: neuropsychological functioning over 8 years in youth. J Int Neuropsychol Soc 8(7):873–883

    Article  PubMed  Google Scholar 

  • Torres-Moreno MC, Papaseit E, Torrens M et al (2018) Assessment of efficacy and tolerability of medicinal cannabinoids in patients with multiple sclerosis: a systematic review and meta-analysis. JAMA network open 1(6):e183485-e

    Article  Google Scholar 

  • Tortoriello G, Morris CV, Alpar A et al (2014) Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway. EMBO J 33(7):668–685

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wong SS, Wilens TE (2017) Medical cannabinoids in children and adolescents: a systematic review. Pediatrics 140(5):e20171818

    Article  PubMed  Google Scholar 

  • Zalesky A, Solowij N, Yücel M et al (2012) Effect of long-term cannabis use on axonal fibre connectivity. Brain 135(7):2245–2255

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Kinderpalliativzentrum, Vestische Kinder- und Jugendklinik - Universität Witten/Herdecke, Datteln, Deutschland

    Stephanie Pieper

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  1. Stephanie Pieper
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Editors and Affiliations

  1. Vestische Kinder- und Jugendklinik, Datteln, Universität Witten/Herdecke, Kinderpalliativzentrum Deutsches Kinderschmerzzentrum, Datteln, Deutschland

    Boris Zernikow

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© 2022 Der/die Autor(en), exklusiv lizenziert durch Springer-Verlag GmbH, DE, ein Teil von Springer Nature

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Pieper, S. (2022). Cannabinoide. In: Zernikow, B. (eds) Pädiatrische Palliativversorgung – Schmerzbehandlung und Symptomkontrolle . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-63148-5_14

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  • DOI: https://doi.org/10.1007/978-3-662-63148-5_14

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  • Print ISBN: 978-3-662-63147-8

  • Online ISBN: 978-3-662-63148-5

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