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Enhancement of Release Profile of Antibiotic from Antibiotic-Loaded Poly(methyl methacrylate) Bone Cement for Anchoring of Total Joint Arthroplasties: A State-of-the-Art Review

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Essentials of Cemented Knee Arthroplasty

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Abstract

The consensus is that periprosthetic joint infection (PJI) is the most devastating and challenging complication of total joint arthroplasty. As such, many aspects of PJI have received much research attention and been the subject of myriad clinical investigations. Among these aspects is the role played by antibiotic-loaded poly(methyl methacrylate) bone cement (ALBC) in both the prevention of PJI and its management/treatment. In both of these capacities, the efficacy of the ALBC is intimately connected with its antibiotic release profile. Results presented in the very large volume of literature on antibiotic release from ALBCs have shown that the release profile is sub-optimal. The present work is a critical review of the growing body of literature on methods for enhancing the release profile, with these ranging from incorporation of a poragen in the cement powder to subjecting test specimens to ultrasound.

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Authors and Affiliations

  1. Department of Mechanical Engineering, The University of Memphis, Memphis, TN, USA

    Gladius Lewis

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  1. Gladius Lewis
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Correspondence to Gladius Lewis .

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Editors and Affiliations

  1. Department of Orthopaedic Surgery, University of California San Francisco UCSF, San Francisco, CA, USA

    Erik Hansen

  2. Department of Orthopedic Surgery, Medical University of Graz, Graz, Austria

    Klaus-Dieter Kühn

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Lewis, G. (2022). Enhancement of Release Profile of Antibiotic from Antibiotic-Loaded Poly(methyl methacrylate) Bone Cement for Anchoring of Total Joint Arthroplasties: A State-of-the-Art Review. In: Hansen, E., Kühn, KD. (eds) Essentials of Cemented Knee Arthroplasty. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-63113-3_48

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  • DOI: https://doi.org/10.1007/978-3-662-63113-3_48

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