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Pathophysiologie: Lipidstoffwechsel

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Nicht-alkoholische Fettlebererkrankung

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Zusammenfassung

Die Leber gilt als das zentrale Stoffwechselorgan des menschlichen Körpers. Neben Proteinbiosynthese, Wärmeregulierung, Glukoseverwertung und Biotransformation sind die Hepatozyten vor allem der Hauptumschlagplatz des Lipidstoffwechsels. Die Leber spielt somit eine entscheidende Rolle in der Fettaufnahme- und Oxidierung, der Fettspeicherung, der Cholesterinsynthese und der Lipogenese. In diesem Kapitel soll auf die Physiologie der hepatischen Fettverdauung und die lipidassoziierte Pathophysiologie der Steatohepatitis eingegangen werden. Dies beinhaltet die Regulation zentraler Stoffwechselprozesse durch nukleäre Rezeptoren, die zentrale Rolle der Insulinresistenz, die Lipotoxizität sowie neue mechanistische Aspekte (z. B. Autophagie).

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Authors and Affiliations

  1. Medizinische Klinik der Ruhr-Universität Bochum, Universitätsklinikum Knappschaftskrankenhaus Bochum GmbH, Bochum, Deutschland

    Lars P. Bechmann & Ali Canbay

  2. Medizinische Klinik und Poliklinik II, Schwerpunkt Hepatologie, Universitätsklinikum Würzburg, Würzburg, Deutschland

    Andreas Geier

Authors
  1. Lars P. Bechmann
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  2. Andreas Geier
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  3. Ali Canbay
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Corresponding author

Correspondence to Lars P. Bechmann .

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Editors and Affiliations

  1. Medizinische Klinik u. Poliklinik II, Universititätsklinikum Würzburg, ZIM, Würzburg, Bayern, Deutschland

    Andreas Geier

  2. Medizinische Klinik, Universitätsklinikum Bochum GmbH, Bochum, Deutschland

    Ali Canbay

  3. Klinik für Innere Medizin II, Universitätsklinikum des Saarlandes, Homburg, Saarland, Deutschland

    Frank Lammert

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Bechmann, L.P., Geier, A., Canbay, A. (2022). Pathophysiologie: Lipidstoffwechsel. In: Geier, A., Canbay, A., Lammert, F. (eds) Nicht-alkoholische Fettlebererkrankung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-62484-5_5

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  • DOI: https://doi.org/10.1007/978-3-662-62484-5_5

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-62483-8

  • Online ISBN: 978-3-662-62484-5

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