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Therapie: Bewegung

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Nicht-alkoholische Fettlebererkrankung
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Zusammenfassung

Bei der Behandlung der nicht-alkoholischen Fettlebererkrankung (NAFLD) spielt Sport eine zentrale Rolle, was sich auch in aktuellen Leitlinien widerspiegelt. Studien demonstrieren, dass mit steigender körperlicher Aktivität das Risiko einer NAFLD sinkt. Außerdem konnte gezeigt werden, dass durch körperliches Training der Fettgehalt der Leber reduziert und die Körperfettzusammensetzung günstig beeinflusst werden, und zwar unabhängig von einer Gewichtreduktion; zudem wird die Insulinresistenz vermindert. Dies unterstreicht die Bedeutung von körperlicher Aktivität in der Therapie der NAFLD, wobei Kraft- und Ausdauertraining vergleichbare Effekte zu haben scheinen. Hierbei besteht vermutlich eine Art Dosis-Wirkungs-Beziehung, da sowohl eine höhere Intensität als auch eine längere Dauer der Aktivität zu besseren Ergebnissen führen. Gelingt es den Patienten, zusätzlich ihr Körpergewicht zu reduzieren, potenzieren sich die positiven Effekte. Dies konnte auch histologisch gezeigt werden. Daten zur optimalen Gestaltung des Trainings fehlen bisher.

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Literatur

  • Ainsworth BE et al (2011) Compendium of physical activities: a second update of codes and MET value. Med Sci Sports Exerc 43:1575–1581

    Article  Google Scholar 

  • Arias-Loste MT et al (2014) Irisin, a link among fatty liver disease, physical inactivity and insulin resistance. Int J Mol Sci 15:23163–23178

    Google Scholar 

  • Bacchi E et al (2013) Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 randomized trial). Hepatology 58:1287–1295

    Google Scholar 

  • Bae JC et al (2012) Regular Exercise is associated with a reduction in the risk of NAFLD and decreased liver enzymes in individuals with NAFLD independent of obesity in Korean adults. PLoS One 7:e46819

    Google Scholar 

  • Begriche K et al (2006) Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. In: Mitochondrion 6:1–28

    Google Scholar 

  • Berzigotti A et al (2014) Lifestyle intervention by a 16-week programme of supervised diet and physical exercise ameliorates portal hypertension in patients with cirrhosis and obesity: the SportDiet study. Hepatology 60(Suppl):253A

    Google Scholar 

  • Chalasani N et al (2018) The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the study of liver diseases. Hepatology 67:328–357

    Google Scholar 

  • Ciolac EG et al (2016) Resistance training as a tool for preventing and treating musculoskeletal disorders. Sports Med 46:1239–1248

    Google Scholar 

  • Cuthbertson DJ et al (2016) Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease. Clin Sci (Lond) 130:93–104

    Google Scholar 

  • Dyson J et al (2014) Treatment of non-alcoholic fatty liver disease. Dig Dis Sci 32:597–604

    Google Scholar 

  • EASL (2016) EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J Hepatol 64:1388–1402

    Google Scholar 

  • Goncalves IO et al (2014) Exercise alters liver mitochondria phospholipidomic profile and mitochondrial activity in non-alcoholic steatohepatitis. Int J Biochem Cell Biol 54:163–173

    Google Scholar 

  • Grøntved A, Hu FB (2011) Television viewing and risk of type 2 diabetes, cardiovascular disease, and all-cause mortality: a meta-analysis. JAMA 305:2448–2455

    Article  Google Scholar 

  • Hallsworth K et al (2011) Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Gut 60:1278–1283

    Google Scholar 

  • Hallsworth K et al (2015) Modified high-intensity interval training reduces liver fat and improves cardiac function in non-alcoholic fatty liver disease: a randomized controlled trial. Clin Sci (Lond) 129:1097–1105

    Google Scholar 

  • Haus JM et al (2013) Improved hepatic lipid composition following short-term exercise in nonalcoholic fatty liver disease. J Clin Endocrinol Metab 98:E1181–E1188

    Google Scholar 

  • Johnson NA et al (2009) Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss. Hepatology 50:1105–1112

    Google Scholar 

  • Johnson NA et al (2010) Fitness versus fatness: moving beyond weight loss in nonalcoholic fatty liver disease. Hepatology 52:370–381

    Google Scholar 

  • Kistler KD et al, The NASH CRN Research Group (2011) Physical activity recommendations, exercise intensity and histological severity of nonalcoholic fatty liver disease. Am J Gastroenterol 106:460–468

    Google Scholar 

  • Kwak MS et al (2015) Role of physical activity in nonalcoholic fatty liver disease in terms of visceral obesity and insulin resistance. Liver Int 35:944–952

    Google Scholar 

  • Lancaster GI et al (2014) The immunomodulating role of exercise in metabolic disease. Trends Immunol 35:262–269

    Google Scholar 

  • Lazo M et al (2010) Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes. Diabetes Care 33:2156–2163

    Google Scholar 

  • Lee SJ et al (2012) Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys. A randomized, controlled trial. Diabetes 61:2787–2795

    Google Scholar 

  • Montesi L et al (2013) Physical activity for the prevention and treatment of metabolic disorders. Intern Emerg Med 8:655–666

    Google Scholar 

  • Nseir W et al (2014) Role of diet and lifestyle changes in nonalcoholic fatty liver disease. World J Gastroenterol 20:9338–9344

    Google Scholar 

  • Oh S et al (2014a) Regular exercise coupled to diet regimen accelerates reduction of hepatic steatosis and associated pathological conditions in nonalcoholic fatty liver disease. Metab Syndr Relat Disord 12:290–298

    Google Scholar 

  • Oh S et al (2014b) Moderate to vigorous physical activity volume is an important factor for managing non-alcoholic fatty liver disease: a retrospective study. Hepatology 61:1205–1215. doi: https://doi.org/10.1002/hep.27544 [Epub ahead of print]

  • Perseghin G et al (2007) Habitual physical activity is associated with intrahepatic fat content in humans. Diabetes Care 30:683–688

    Google Scholar 

  • Piano A et al (2012) Long-term effects of aerobic plus resistance training on the adipokines and neuropeptides in nonalcoholic fatty liver disease obese adolescents. Eur J Gastroenterol Hepatol 24:1313–1324

    Google Scholar 

  • Potenza MA et al (2017) Targeting endothelial metaflammation to counteract diabesity cardiovascular risk: current and perspective therapeutic options. Pharmacol Res 120:226–241

    Google Scholar 

  • Promrat K et al (2010) Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology 51:121–129

    Google Scholar 

  • Pugh CJA et al (2014) Exercise training reverses endothelial dysfunction in non-alcoholic fatty liver disease. Am J Physiol Heart Circ Physiol 307:H1298–H1306

    Google Scholar 

  • Roeb E et al (2015) S2k-Leitlinie nicht alkoholische Fettlebererkrankung. Z Gastroenterol 53: 668–723

    Google Scholar 

  • Romero-Gomez et al (2017) Treatment of NAFLD with diet, physical activity and exercise. J Hepatol 67:829–846

    Google Scholar 

  • Serviddio G et al (2011) Mitochondrial dysfunction in nonalcoholic steatohepatitis. Expert Rev Gastroenterol Hepatol 5:233–244

    Google Scholar 

  • Silva MAA et al (2012) Effects of swim training on liver carcinogenesis in male Wistar rats fed a low-fat or high-fat diet. Appl Physiol Nutr Metab 37:1101–1109

    Google Scholar 

  • Takahashi A et al (2015) Simple resistance exercise helps patients with non-alcoholic fatty liver disease. Int J Sports Med 36:848–852

    Google Scholar 

  • Watson K et al (2014) mTOR and the health benefits of exercise. Semin Cell Dev Biol 36:130–139

    Google Scholar 

  • Wilkins T et al (2013) Nonalcoholic fatty liver disease: diagnosis and management. Am Fam Phys 88:35–42

    Google Scholar 

  • Zelber-Sagi S et al (2008) Role of leisure-time physical activity in nonalcoholic fatty liver disease: a population-based study. Hepatology 48:1791–1798

    Google Scholar 

  • Zelber-Sagi S et al (2014) Effect of resistance training on non-alcoholic fatty-liver disease a randomized-clinical trial. World J Gastroenterol 2014(20):4382–4392

    Article  Google Scholar 

  • Zheng F, Cai Y (2019) Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-γ and genes involved in the beta-oxidation of fatty acids in ApoE-KO mice fed a high-fat diet. Lipids Health Dis 18:1–8. doi: https://doi.org/10.1186/s12944-018-0933-z

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Correspondence to Johannes Weiss .

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© 2022 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

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Weiss, J. (2022). Therapie: Bewegung. In: Geier, A., Canbay, A., Lammert, F. (eds) Nicht-alkoholische Fettlebererkrankung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-62484-5_18

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  • DOI: https://doi.org/10.1007/978-3-662-62484-5_18

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