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SkinDot® als neues Vollhaut-Transplantationsverfahren

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Hauttransplantation

Zusammenfassung

Die Spalthauttransplantation ist das operative Standardverfahren im Rahmen der akuten und chronischen Wundversorgung, führt jedoch nicht zu einem Ersatz einer dermalen Schicht. Dermale Hautschichten sind als Verschiebeschicht und Träger der Hautanhangsgebilde wie Haare, Schweiß- und Talgdrüsen sowie Nervenrezeptoren für Druck, Vibration- und Temperaturempfinden und somit für die Qualität der transplantierten Haut unverzichtbar. Vollhauttransplantate können aufgrund des limitierten Spenderareals jedoch maximal 2–3 % der Körperoberfläche ersetzen. Kulturhautverfahren, die auf gezüchteten Hautzellen im Labor beruhen, können derzeit noch keinen Vollhautersatz erreichen. SkinDot® entwickelt ein neues Transplantationsverfahren mit korrespondierenden technischen Geräten (Devices), das eine sofortige autologe, intraoperative Wundversorgung ermöglicht und zu einem großflächigen Vollhautäquivalent führt.

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Literatur

  1. Rives JM, Sellam P, Karcenty B (1994) Cultured epithelial autografts (CEA) management and colonization control in extensive burn injuries: "Thoughts on local dressing", 9th Congress of the International Society for Burn, 1994.

    Google Scholar 

  2. Ottomann C, Gatz K, Buntrok G et al (2020) SkinDot: a modified full-skin transplantation technique. Ann Surg 229(5):151454

    Google Scholar 

  3. Ottomann C, Buntrock G, Wiegel M et al (2017) Feed motion resection force analysis of 1 mm and 2 mm biopsy punches ontempered human cadaver skin use for the acquisition of full skin islets for skin transplantation. Int J Biotechnol Bioeng 3(5):57–64

    Google Scholar 

  4. Ottomann C, Krziminski S, Buntrock G et al (2017) Development of an intraoperative procedure for producing an autologous full skin equivalent – prototype design and pilot resection force and tensile strength measurements. Int J Biotechnol Bioeng 3(5):65–70

    Google Scholar 

  5. Ottomann C, Kranz S, Weyers I et al (2017) Resection force analysis of 1 and 2 mm punch biospies combined with rotation on temperature-controlled cadaver skin use for the acquisition of full skin islets for skin transplantation. Int J Biotechnol Bioeng 3(5):57–62

    Google Scholar 

  6. Smolle C, Brinskelle P, Steiner A et al (2017) Skin graft fixation in severe burns: use of topical negative pressure. In: Recent clinical techniques, results, and research in wounds. Springer Medizin, Cham

    Google Scholar 

  7. Motamed S, Niazi F, Atarian S et al (2008) Post-burn head and neck reconstruction using tissue expanders. Burns 34(6):878–884

    Article  CAS  PubMed  Google Scholar 

  8. Guogiene I, Kievisas M, Varkalys K et al (2018) Split-thickness skin grafting using grafts of different thickness. Eur J Plast Surg 41:583–590

    Article  Google Scholar 

  9. Debels H, Hamdi M, Abberton K, Morrison W (2015) Dermal matrices and bioengineered skin substitutes: a critical review of current options. Plast Reconstr Surg Glob Open 3(1):e284

    Article  PubMed  PubMed Central  Google Scholar 

  10. Rheinwald JG, Green H (1975) Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma. Cell 6(3):317–330

    Article  CAS  PubMed  Google Scholar 

  11. Still JM, Orlet HK, Law EJ (1994) Use of cultured epidermal autografts in the treatment of large burns. Burns 20(6):539–541

    Article  PubMed  Google Scholar 

  12. Cuono C, Langdon R, McGuire J (1986) Use of cultured epidermal autografts and dermal allografts as skin replacement after burn injury. Lancet 327(8490):1123–1124

    Article  Google Scholar 

  13. Hartmann B, Ottomann C (2016) Tissue engineering der Haut. In: Lehnhardt M, Hartmann B, Reichert B (Hrsg) Verbrennungschirurgie. Springer, Berlin, Heidelberg

    Google Scholar 

  14. Atiyeh BS, Costagliola M (2007) Cultured epithelial autograft (CEA) in burn treatment: three decades later. Burns 33(4):405–413

    Article  PubMed  Google Scholar 

  15. Nyame T, Chiang HA, Abraham M (2015) Tissue-engineered skin substitutes. Plast Reconstr Surg 136(6):1279–1388

    Article  Google Scholar 

  16. Ehrenfied A (1909) Reverdin and other methods of skin-grafting. Boston Med Surg 161:911–917

    Article  Google Scholar 

  17. Davis JS (1914) The use of small deep skin grafts. JAMA LXIII(12):985–989

    Article  Google Scholar 

Download references

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Correspondence to Christian Ottomann .

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Ottomann, C., Gatz, K., Buntrock, G. (2022). SkinDot® als neues Vollhaut-Transplantationsverfahren. In: Ottomann, C., Hartmann, B. (eds) Hauttransplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-62060-1_22

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  • DOI: https://doi.org/10.1007/978-3-662-62060-1_22

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