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Laboruntersuchung in der pädiatrischen Rheumatologie

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Pädiatrische Rheumatologie

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Zusammenfassung

Bei den meisten rheumatischen Erkrankungen im Kindes- und Jugendalter handelt es sich um Autoimmunopathien, also um chronisch-inflammatorische Prozesse auf der Basis einer Reaktion des Immunsystems gegen Moleküle des eigenen Organismus. Dabei kommt es häufig zur Bildung diagnostisch relevanter Autoantikörper und zur Aktivierung von antigenspezifischen T-Zellen. Die Autoantikörper sind das augenscheinlichste Merkmal des Autoimmunprozesses; sie korrelieren bei einigen Autoimmunopathien mit der Krankheitsaktivität und können als Verlaufsparameter für den intraindividuellen Vergleich herangezogen werden. Die Diagnose von rheumatischen Erkrankungen ist immer eine Ausschlussdiagnose. Das „rheumatologische Basislabor“ umfasst neben einem Blutbild die Bestimmung von Entzündungsparametern wie die Blutkörperchensenkungsgeschwindigkeit, das C-reaktives Protein, Serumimmunglobuline, S100-Proteine und eine Komplementanalyse sowie die Bestimmung von Rheumafaktoren und Autoantikörpern wie Anticitrullin-Antikörper, antinukleäre Antikörper (ANA), ENA-Antikörper, und eventuell Antikörper gegen Doppelstrang-DNA (ds-DNA), Myositis-Antikörper und antineutrophile zytoplasmatische Antikörper (ANCA). Die molekulargenetischen Analysen sind bei den Autoinflammationserkrankungen („chronic autoinflammatory disorders“, periodische Fiebersyndrome) hilfreich.

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Authors and Affiliations

  1. Department Kinder- und Jugendheilkunde, Medizinische Universität Innsbruck, Innsbruck, Österreich

    Jürgen Brunner

  2. Labor Berlin – Charité Vivantes GmbH, Berlin, Deutschland

    José-Bernardino González-González

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  1. Jürgen Brunner
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Correspondence to Jürgen Brunner .

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Editors and Affiliations

  1. Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Aachen, Aachen, Deutschland

    Norbert Wagner

  2. Sektion Rheumatologie der Klinik für Pädiatrie m.S. Pneumologie, Immunologie und Intensivmedizin mit Bereich Rheumatologie, im Sozialpädiatrischen ZentrumCharité - Universitätsmedizin Berlin, Berlin, Deutschland

    Günther Dannecker

  3. Sektion Rheumatologie der Klinik für Pädiatrie m.S. Pneumologie, Immunologie und Intensivmedizin mit Bereich Rheumatologie, im Sozialpädiatrischen ZentrumCharité - Universitätsmedizin Berlin, Berlin, Deutschland

    Tilmann Kallinich

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Brunner, J., González-González, JB. (2022). Laboruntersuchung in der pädiatrischen Rheumatologie. In: Wagner, N., Dannecker, G., Kallinich, T. (eds) Pädiatrische Rheumatologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-60410-6_8

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