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Antiallergika

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Literatur

  • Abramson M, Puy R, Weiner J (2003) Allergen immunotherapy for asthma (Cochrane Review). Cochrane Libr. https://doi.org/10.1002/14651858.CD001186

    Article  Google Scholar 

  • Adkinson NF, Eggleston PA, Eney D, Goldstein EO, Schuberth KC et al (1997) A controlled trial of immunotherapy for asthma in allergic children. N Engl J Med 336:324–331

    CAS  PubMed  Google Scholar 

  • Arvidsson MB, Löwhagen O, Rak S (2002) Effect of 2-year placebo-controlled immunotherapy on airway symptoms and medication in patients with birch pollen allergy. J Allergy Clin Immunol 109:777–783

    CAS  PubMed  Google Scholar 

  • BKK Dachverband (2019) Stellungnahme des BKK Dachverbandes e.V. vom 04. April 2019 zum Entwurf eines Gesetzes für mehr Sicherheit in der Arzneimittelversorgung (GSAV) BT-Drs. 19/8753. https://www.bkk-dachverband.de/fileadmin/user_upload/20190404_BKK_DV_Stellungnahme_GE_GSAV.pdf

    Google Scholar 

  • Bousquet J, Hejjaoui A, Clauzel AM, Guerin B, Dhivert H, Skassa-Brociek W, Wichel FB (1988) Specific immunotherapy with a standardized Dermatophagoides pteronyssinus extract. II. Prediction of efficacy of immunotherapy. J Allergy Clin Immunol 82:971–977

    CAS  PubMed  Google Scholar 

  • Bousquet J, Scheinmann P, Guinnepain MT, Perrin-Fayolle M, Sauvaget J, Tonnel AB et al (1999) Sublingual-swallow immunotherapy (SLIT) in patients with asthma due to house-dust mites: a double-blind, placebo-controlled study. Allergy 54:249–260

    CAS  PubMed  Google Scholar 

  • Bundesministerin für Gesundheit (2008): Verordnung über die Ausdehnung der Vorschriften über die Zulassung der Arzneimittel auf Therapieallergene, die für einzelne Personen auf Grund einer Rezeptur hergestellt werden, sowie über Verfahrensregelungen der staatlichen Chargenprüfung (Therapieallergene-Verordnung) vom 7. November 2008. Bundesgesetzblatt 2008 Teil I Nr. 51, Bonn 13. November 2008, Seite 2177–2178. Internet: www.bgbl.de/Xaver/start.xav?startbk=Bundesanzeiger_BGBl

  • Calderon MA, Alves B, Jacobson M, Hurwitz B, Sheikh A, Durham S (2007) Allergen injection immunotherapy for seasonal allergic rhinitis. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD001936.pub2

    Article  PubMed  PubMed Central  Google Scholar 

  • Calderon M, Mösges R, Hellmich M, Demoly P (2010) Towards evidence-based medicine in specific grass pollen immunotherapy. Allergy 65:420–434

    CAS  PubMed  Google Scholar 

  • Dahl R, Kapp A, Colombo G, de Monchy JG, Rak S, Emminger W, Rivas MF, Ribel M, Durham SR (2006) Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol 118:434–440

    CAS  PubMed  Google Scholar 

  • Dahl R, Kapp A, Colombo G, de Monchy JG, Rak S, Emminger W, Riis B, Grønager PM, Durham SR (2008) Sublingual grass allergen tablet immunotherapy provides sustained clinical benefit with progressive immunologic changes over 2 years. J Allergy Clin Immunol 121:512–518

    CAS  PubMed  Google Scholar 

  • DAZ-Online (2016) Epipen in den USA − Lebenswichtiges Arzneimittel wird unbezahlbar. https://www.deutsche-apotheker-zeitung.de/news/artikel/2016/08/31/lebenswichtiges-arzneimittel-wird-unbezahlbar

    Google Scholar 

  • Demoly P, Emminger W, Rehm D, Backer V, Tommerup L, Kleine-Tebbe J (2016) Effective treatment of house dust mite-induced allergic rhinitis with 2 doses of the SQ HDM SLIT-tablet: Results from a randomized, double-blind, placebo-controlled phase III trial. J Allergy Clin Immunol 137:444–451

    CAS  PubMed  Google Scholar 

  • Devillier P, Dreyfus JF, Demoly P, Calderón MA (2014) A meta-analysis of sublingual allergen immunotherapy and pharmacotherapy in pollen-induced seasonal allergic rhinoconjunctivitis. BMC Med 12:71. https://doi.org/10.1186/1741-7015-12-71

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dhami S, Kakourou A, Asamoah F, Agache I, Lau S, Jutel M, Muraro A, Roberts G, Akdis CA, Bonini M, Cavkaytar O, Flood B, Gajdanowicz P, Izuhara K, Kalayci Ö, Mosges R, Palomares O, Pfaar O, Smolinska S, Sokolowska M, Asaria M, Netuveli G, Zaman H, Akhlaq A, Sheikh A (2017a) Allergen immunotherapy for allergic asthma: a systematic review and meta-analysis. Allergy 72:1825–1848

    CAS  PubMed  Google Scholar 

  • Dhami S, Zaman H, Varga EM, Sturm GJ, Muraro A, Akdis CA, Antolín-Amérigo D, Bilò MB, Bokanovic D, Calderon MA, Cichocka-Jarosz E, Oude Elberink JN, Gawlik R, Jakob T, Kosnik M, Lange J, Mingomataj E, Mitsias DI, Mosbech H, Ollert M, Pfaar O, Pitsios C, Pravettoni V, Roberts G, Ruëff F, Sin BA, Asaria M, Netuveli G, Sheikh A (2017b) Allergen immunotherapy for insect venom allergy: a systematic review and meta-analysis. Allergy 72:342–365

    CAS  PubMed  Google Scholar 

  • Didier A, Malling HJ, Worm M, Horak F, Jäger S, Montagut A, Andre C, de Beaumont O, Melac M (2007) Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5-grasspollen tablet for seasonal allergic rhinitis. J Allergy Clin Immunol 120:1338–1345

    CAS  PubMed  Google Scholar 

  • Durham SR, Walker SM, Varga EM, Jacobson MR, O’Brian F, Noble W et al (1999) Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med 341:468–475

    CAS  PubMed  Google Scholar 

  • Englert L, May S, Kaul S, Vieths S (2012) Die Therapieallergene-Verordnung – Hintergrund und Auswirkungen. Bundesgesundheitsbl 55:351–357

    CAS  Google Scholar 

  • Guez S, Vatrinet C, Fadel R, Andre C (2000) House-dust-mite sublingual-swallow immunotherapy (SLIT) in perennial rhinitis: a double-blind, placebo-controlled study. Allergy 55:369–375

    CAS  PubMed  Google Scholar 

  • Hoff M, Krail M, Kästner M, Haustein D, Vieths S (2002) Fusarium culmorum causes strong degradation of pollen allergens in extract mixtures. J Allergy Clin Immunol 109:96–101

    PubMed  Google Scholar 

  • James C, Bernstein DI (2017) Allergen immunotherapy: an updated review of safety. Curr Opin Allergy Clin Immunol 17:55–59

    CAS  PubMed  PubMed Central  Google Scholar 

  • Jutel M, Agache I, Bonini S, Burks AW, Calderon M, Canonica W, Cox L, Demoly P, Frew AJ, O’Hehir R, Kleine-Tebbe J, Muraro A, Lack G, Larenas D, Levin M, Nelson H, Pawankar R, Pfaar O, van Ree R, Sampson H, Santos AF, Du Toit G, Werfel T, Gerth van Wijk R, Zhang L, Akdis CA (2015) International consensus on allergy immunotherapy. J Allergy Clin Immunol 136:556–568

    PubMed  Google Scholar 

  • Kassenärztliche Vereinigung Baden-Württemberg (2015) SCIT und SLIT: Neue S2k-Leitlinie nimmt Präparate in den Fokus. Verordnungsforum 34, S 8–15

    Google Scholar 

  • Kiel MA, Röder E, Gerth van Wijk R, Al MJ, Hop WC, Rutten-van Mölken MP (2013) Real-life compliance and persistence among users of subcutaneous and sublingual allergen immunotherapy. J Allergy Clin Immunol 132:353–360

    PubMed  Google Scholar 

  • Klimek I, Vogelberg C, Hamelmann E (2015) Allergenspezifische Immuntherapie: interessante Bewertungen und korrekturbedürftige Fehleinschätzungen. Allergo J 24:68–71

    Google Scholar 

  • Larenas-Linnemann D (2016) How does the efficacy and safety of Oralair® compare to other products on the market? Ther Clin Risk Manag 12:831–850

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lüderitz-Püchel U, Keller-Stanislawski B, Haustein D (2001) Neubewertung des Risikos von Test- und Therapieallergenen. Eine Analyse der UAW-Meldungen von 1991 bis 2000. Bundesgesunheitsbl – Gesundheitsforsch – Gesundheitsschutz 44:709–718

    Google Scholar 

  • Meadows A, Kaambwa B, Novielli N, Huissoon A, Fry-Smith A, Meads C, Barton P, Dretzke J (2013) A systematic review and economic evaluation of subcutaneous and sublingual allergen immunotherapy in adults and children with seasonal allergic rhinitis. Health Technol Assess 17:1–322

    Google Scholar 

  • Mellerup MT, Hahn GW, Poulsen LK, Malling HJ (2000) Safety of allergen-specific immunotherapy. Relation between dosage regimen, allergen extract, disease and systemic side-effects during induction treatment. Clin Exp Allergy 30:1423–1429

    CAS  PubMed  Google Scholar 

  • Möller C, Dreborg S, Ferdousi HA, Halken S, Høst A, Jacobsen L et al (2002) Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-Study). J Allergy Clin Immunol 109:251–256

    PubMed  Google Scholar 

  • Nelson HS (2007) Allergen immunotherapy: where is it now? J Allergy Clin Immunol 119:769–779

    CAS  PubMed  Google Scholar 

  • Olsen OT, Larsen KR, Jacobsan L, Svedsen UG (1997) A 1-year placebo-controlled, double-blind house-dust-mite immunotherapy study in asthmatic adults. Allergy 52:853–859

    CAS  PubMed  Google Scholar 

  • O’Neill SM, Forsyth A (1988) Urticaria. Prescr J 28:14–20

    Google Scholar 

  • Paul-Ehrlich-Institut (2019a) Therapieallergene-Verordnung trägt Früchte. https://www.pei.de/DE/infos/presse/pressemitteilungen/2018/13-therapieallergene-verordnung-traegt-fruechte.html

    Google Scholar 

  • Paul-Ehrlich-Institut (2019b) Zugelassene Therapie-Allergene. https://www.pei.de/DE/arzneimittel/allergene/therapie-allergene/therapie-allergene-node.html

    Google Scholar 

  • Pfaar O, Bachert C, Bufe A, Buhl R, Ebner C, Eng P, Friedrichs F, Fuchs T, Hamelmann E, Hartwig-Bade D, Hering T, Hutteger I, Jung K, Klimek L, Kopp MV, Merk H, Rabe U, Saloga J, Schmid-Grendelmeier P, Schuster A, Schwerk N, Sitter H, Umpfenbach U, Wedi B, Wöhrl S, Worm M, Kleine-Tebbe J (2014) Leitlinie zur (allergen-)spezifischen Immuntherapie bei IgE-vermittelten allergischen Erkrankungen. Allergo J Int 23:282–319

    PubMed  PubMed Central  Google Scholar 

  • Pichler CE, Marquardsen A, Sparholt S, Lowenstein H, Bircher A, Bischof M, Pichler WJ (1997) Specific immunotherapy with Dermatophagoides ptheronyssinus and D. farinae results in decreased bronchial hyperreactivity. Allergy 52:274–283

    CAS  PubMed  Google Scholar 

  • Radulovic S, Wilson D, Calderon M, Durham S (2011) Systematic reviews of sublingual immunotherapy (SLIT). Allergy 66:740–752

    CAS  PubMed  Google Scholar 

  • Rietschel E, Hutegger I, Lange L, Urbanek R (2013) Anaphylaxie – Diagnostisches und therapeutisches Vorgehen. Med Klin Intensivmed Notfmed 108:239–249

    CAS  PubMed  Google Scholar 

  • Roberts G, Pfaar O, Akdis CA, Ansotegui IJ, Durham SR, Gerth van Wijk R, Halken S, Larenas-Linnemann D, Pawankar R, Pitsios C, Sheikh A, Worm M, Arasi S, Calderon MA, Cingi C, Dhami S, Fauquert JL, Hamelmann E, Hellings P, Jacobsen L, Knol EF, Lin SY, Maggina P, Mösges R, Oude Elberink JNG, Pajno GB, Pastorello EA, Penagos M, Rotiroti G, Schmidt-Weber CB, Timmermans F, Tsilochristou O, Varga EM, Wilkinson JN, Williams A, Zhang L, Agache I, Angier E, Fernandez-Rivas M, Jutel M, Lau S, van Ree R, Ryan D, Sturm GJ, Muraro A (2018) EAACI guidelines on allergen immunotherapy: allergic rhinoconjunctivitis. Allergy 73:765–798

    CAS  PubMed  Google Scholar 

  • Scaparrotta A, Attanasi M, Petrosino MI, Di Filippo P, Di Pillo S, Chiarelli F (2015) Critical appraisal of Timothy grass pollen extract GRAZAX in the management of allergic rhinitis. Drug Des Devel Ther 9:5897–5909

    CAS  PubMed  PubMed Central  Google Scholar 

  • Valsecchi R, di Landro A, Pansera B, Cainelli T (1994) Contact dermatitis from a gel containing dimethindene maleate. Contact Dermatitis 30:248–249

    PubMed  Google Scholar 

  • Virchow JC, Backer V, Kuna P, Prieto L, Nolte H, Villesen HH, Ljørring C, Riis B, de Blay F (2016) Efficacy of a house dust mite sublingual allergen immunotherapy tablet in adults with allergic asthma: a randomized clinical trial. JAMA 315:1715–1725

    CAS  PubMed  Google Scholar 

  • Wheatley LM, Togias A (2015) Clinical practice. Allergic rhinitis. N Engl J Med 372:456–463

    PubMed  PubMed Central  Google Scholar 

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Zawinell, A., Schwabe, U. (2019). Antiallergika. In: Schwabe, U., Paffrath, D., Ludwig, WD., Klauber, J. (eds) Arzneiverordnungs-Report 2019. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-59046-1_11

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