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Ovulationsinduktion und ovarielle Stimulation

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Zusammenfassung

Das Wirkprinzip der ovariellen Stimulation beruht auf einer indirekten oder direkten Erhöhung des Serum-FSH-Spiegels. Das therapeutische Ziel der ovariellen Stimulation ist entweder die Unterstützung bzw. Herbeiführung eines Eisprungs bei Störung der Follikelreifung oder die Polyovulation zur Gewinnung von mehreren Eizellen für eine extrakorporale Verwendung.

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Literatur

  • Al-Inany HG, Youssef MA, Aboulghar M, Broekmans F, Sterrenburg M, Smit J, Abou-Setta AM (2011) Gonadotrophin-releasing hormone antagonists for assisted reproductive technology. Cochrane Database Syst Rev (5):CD001750. https://doi.org/10.1002/14651858.CD001750.pub3

  • Al-Inany HG, Youssef MA, Ayeleke RO, Brown J, Lam WS, Broekmans FJ (2016) Gonadotrophin-releasing hormone antagonists for assisted reproductive technology. Cochrane Database Syst Rev (4):CD001750

    Google Scholar 

  • Amer SA, Li TC, Cooke ID (2003) A prospective dose-finding study of the amount of thermal energy required for laparoscopic ovarian diathermy. Hum Reprod 18(8):1693–1698

    Article  CAS  PubMed  Google Scholar 

  • Amer SA, Li TC, Metwally M, Emarh M, Ledger WL (2009) Randomized controlled trial comparing laparoscopic ovarian diathermy with clomiphene citrate as a first-line method of ovulation induction in women with polycystic ovary syndrome. Hum Reprod 24(1):219–225

    Article  CAS  PubMed  Google Scholar 

  • Andersen AG, Als-Nielsen B, Hornnes PJ, Franch Andersen L (1995) Time interval from human chorionic gonadotrophin (HCG) injection to follicular rupture. Hum Reprod 10(12):3202–3205

    Article  CAS  PubMed  Google Scholar 

  • Andersen AN, Witjes H, Gordon K, Mannaerts B, Xpect investigators (2011) Predictive factors of ovarian response and clinical outcome after IVF/ICSI following a rFSH/GnRH antagonist protocol with or without oral contraceptive pre-treatment. Hum Reprod 26(12):3413–3423

    Article  CAS  PubMed  Google Scholar 

  • Balasch J, Fábregues F, Creus M, Casamitjana R, Puerto B, Vanrell JA (2000) Recombinant human follicle-stimulating hormone for ovulation induction in polycystic ovary syndrome: a prospective, randomized trial of two starting doses in a chronic low-dose step-up protocol. J Assist Reprod Genet 17(10):561–565

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Balen A, Platteau P, Andersen AN, Devroey P, Helmgaard L, Arce JC, for the Bravelle Ovulation Induction (BOI) Study Group (2007) Highly purified FSH is as efficacious as recombinant FSH for ovulation induction in women with WHO Group II anovulatory infertility: a randomized controlled non-inferiority trial. Hum Reprod 22(7):1816–1823

    Article  CAS  PubMed  Google Scholar 

  • Beckers NG, Macklon NS, Eijkemans MJ, Ludwig M, Felberbaum RE, Diedrich K, Bustion S, Loumaye E, Fauser BC (2003) Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilization patients after ovarian stimulation with recombinant follicle-stimulating hormone and GnRH antagonist cotreatment. J Clin Endocrinol Metab 88(9):4186–4192

    Article  CAS  PubMed  Google Scholar 

  • Bodri D, Guillén JJ, Galindo A, Mataró D, Pujol A, Coll O (2009) Triggering with human chorionic gonadotropin or a gonadotropin-releasing hormone agonist in gonadotropin-releasing hormone antagonist-treated oocyte donor cycles: findings of a large retrospective cohort study. Fertil Steril 91(2):365–371

    Article  CAS  PubMed  Google Scholar 

  • Boostanfar R, Shapiro B, Levy M, Rosenwaks Z, Witjes H, Stegmann BJ, Elbers J, Gordon K, Mannaerts B, Pursue investigators (2015) Large, comparative, randomized double-blind trial confirming noninferiority of pregnancy rates for corifollitropin alfa compared with recombinant follicle-stimulating hormone in a gonadotropin-releasing hormone antagonist controlled ovarian stimulation protocol in older patients undergoing in vitro fertilization. Fertil Steril 104(1):94–103

    Article  CAS  PubMed  Google Scholar 

  • Bosch E, Labarta E, Crespo J, Simón C, Remohí J, Jenkins J, Pellicer A (2010) Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod 25(8):2092–2100

    Article  CAS  PubMed  Google Scholar 

  • Braam SC, de Bruin JP, Buisman ETIA, Brandes M, Nelen WLDM, Smeenk JMJ, van der Steeg JW, Mol BWJ, Hamilton CJCM (2018) Treatment strategies and cumulative live birth rates in WHO-II ovulation disorders. Eur J Obstet Gynecol Reprod Biol 225:84–89

    Article  PubMed  Google Scholar 

  • Broekmans FJ, de Ziegler D, Howles CM, Gougeon A, Trew G, Olivennes F (2010) The antral follicle count: practical recommendations for better standardization. Fertil Steril 94(3):1044–1051

    Article  PubMed  Google Scholar 

  • Broekmans FJ, Verweij PJ, Eijkemans MJ, Mannaerts BM, Witjes H (2014) Prognostic models for high and low ovarian responses in controlled ovarian stimulation usinga GnRH antagonist protocol. Hum Reprod 29(8):1688–1697

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Broer SL, Dólleman M, Opmeer BC, Fauser BC, Mol BW, Broekmans FJ (2011) AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis. Hum Reprod Update 17(1):46–54

    Article  CAS  PubMed  Google Scholar 

  • Brown J, Farquhar C, Beck J, Boothroyd C, Hughes E (2009) Clomiphene and anti-oestrogens for ovulation induction in PCOS. Cochrane Database Syst Rev (4):CD002249

    Google Scholar 

  • Cantineau AE, Cohlen BJ, Heineman MJ (2007) Ovarian stimulation protocols (anti-oestrogens, gonadotrophins with and without GnRH agonists/antagonists) for intrauterine insemination (IUI) in women with subfertility. Cochrane Database Syst Rev (2):CD005356

    Google Scholar 

  • Cantineau AE, Janssen MJ, Cohlen BJ (2010) Synchronised approach for intrauterine insemination in subfertile couples. Cochrane Database Syst Rev (4):CD006942

    Google Scholar 

  • Cantineau AE, Cohlen BJ, Klip H, Heineman MJ, Dutch IUI Study Group Collaborators (2011) The addition of GnRH antagonists in intrauterine insemination cycles with mild ovarian hyperstimulation does not increase live birth rates – a randomized, double-blinded, placebo-controlled trial. Hum Reprod 26(5):1104–1111

    Article  CAS  PubMed  Google Scholar 

  • Casper RF, Mitwally MF (2011) Use of the aromatase inhibitor letrozole for ovulation induction in women with polycystic ovarian syndrome. Clin Obstet Gynecol 54(4):685–695

    Article  PubMed  Google Scholar 

  • Chan CC, Ng EH, Chan MM, Tang OS, Lau EY, Yeung WS, Ho PC (2003) Bioavailability of hCG after intramuscular or subcutaneous injection in obese and on-obese women. Hum Reprod 18(11):2294–2297

    Article  CAS  PubMed  Google Scholar 

  • Chang P, Kenley S, Burns T, Denton G, Currie K, DeVane G, O’Dea L (2001) Recombinant human chorionic gonadotropin (rhCG) in assisted reproductive technology: results of a clinical trial comparing two doses of rhCG (Ovidrel) to urinary hCG (Profasi) for induction of final follicular maturation in in vitro fertilization embryo transfer. Fertil Steril 76:67–74

    Article  CAS  PubMed  Google Scholar 

  • Christin-Maitre S, Hugues JN, Recombinant FSH Study Group (2003) A comparative randomized multicentric study comparing the step-up versus step-down protocol in polycystic ovary syndrome. Hum Reprod 18(8):1626–1631

    Article  CAS  PubMed  Google Scholar 

  • Chun E (2005) Severe OHSS can be prevented in GnRH antagonist protocol using GnRHa to trigger ovulation. Fertil Steril 84(Suppl 1):S301 (P-149)

    Google Scholar 

  • Clark L, Stanger J, Brinsmead M (1991) Prolonged follicle stimulation decreases pregnancy rates after in vitro fertilization. Fertil Steril 55(6):1192–1194

    Article  CAS  PubMed  Google Scholar 

  • Cour Freiesleben N la, Lossl K, Bogstad J, Bredkjaer HE, Toft B, Rosendahl M, Loft A, Bangsboll S, Pinborg A, Nyboe Andersen A (2009) Individual versus standard dose of rFSH in a mild stimulation protocol for intrauterine insemination: a randomized study. Hum Reprod 24(10):2523–2530

    Google Scholar 

  • Couzinet B, Lestrat N, Brailly S, Forest M, Schaison G (1988) Stimulation of ovarian follicular maturation with pure follicle stimulating hormone in women with gonadotropin deficiency. J Clin Endocrinol Metab 66:552–556

    Article  CAS  PubMed  Google Scholar 

  • Crosignani PG, Somigliana E, Intrauterine Insemination Study Group (2007) Effect of GnRH antagonists in FSH mildly stimulated intrauterine insemination cycles: a multicentre randomized trial. Hum Reprod 22(2):500–505

    Article  CAS  PubMed  Google Scholar 

  • D’Angelo A, Brown J, Amso NN (2011) Coasting (withholding gonadotrophins) for preventing ovarian hyperstimulation syndrome. Cochrane Database Syst Rev (6):CD002811

    Google Scholar 

  • Daya S (2007) WITHDRAWN: Gonadotrophin-releasing hormone agonist protocols for pituitary desensitization in in vitro fertilization and gamete intrafallopian transfer cycles. Cochrane Database Syst Rev (1):CD001299

    Google Scholar 

  • Devroey P, Boostanfar R, Koper NP, Mannaerts BM, Ijzerman-Boon PC, Fauser BC (2009a) A double-blind, non-inferiority RCT comparing corifollitropin alfa and recombinant FSH during the first seven days of ovarian stimulation using a GnRH antagonist protocol. Hum Reprod 24(12):3063–3072

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Devroey P, Aboulghar M, Garcia-Velasco J, Griesinger G, Humaidan P, Kolibianakis E, Ledger W, Tomás C, Fauser BC (2009b) Improving the patient’s experience of IVF/ICSI: a proposal for an ovarian stimulation protocol with GnRH antagonist co-treatment. Hum Reprod 24(4):764–774

    Article  CAS  PubMed  Google Scholar 

  • Dickey RP, Taylor SN, Curole DN, Rye PH, Pyrzak R (1996) Incidence of spontaneous abortion in clomiphene pregnancies. Hum Reprod 11:2623–2628

    Article  CAS  PubMed  Google Scholar 

  • Diedrich K, Diedrich C, Santos E, Zoll C, al-Hasani S, Reissmann T, Krebs D, Klingmüller D (1994) Suppression of the endogenous luteinizing hormone surge by the gonadotrophin-releasing hormone antagonist Cetrorelix during ovarian stimulation. Hum Reprod 9(5):788–791

    Article  CAS  PubMed  Google Scholar 

  • Driscoll GL, Tyler JP, Hangan JT, Fisher PR, Birdsall MA, Knight DC (2000) A prospective, randomized, controlled, double-blind, double-dummy comparison of recombinant and urinary HCG for inducing oocyte maturation and follicular luteinization in ovarian stimulation. Hum Reprod 15:1305–1310

    Article  CAS  PubMed  Google Scholar 

  • Dubourdieu S, Le Nestour E, Spitz IM, Charbonnel B, Bouchard P (1993) The combination of gonadotrophin-releasing hormone (GnRH) antagonist and pulsatile GnRH normalizes luteinizing hormone secretion in polycystic ovarian disease but fails to induce follicular maturation. Hum Reprod 8(12):2056–2060

    Article  CAS  PubMed  Google Scholar 

  • Duijkers IJ, Klipping C, Boerrigter PJ, Machielsen CS, De Bie JJ, Voortman G (2002) Single dose pharmacokinetics and effects on follicular growth and serum hormones of a long-acting recombinant FSH preparation (FSH-CTP) in healthy pituitary-suppressed females. Hum Reprod 17(8):1987–1993

    Article  CAS  PubMed  Google Scholar 

  • Eijkemans MJ, Imani B, Mulders AG, Habbema JD, Fauser BC (2003) High singleton live birth rate following classical ovulation induction in normogonadotrophic anovulatory infertility (WHO 2). Hum Reprod 18(11):2357–2362

    Article  PubMed  Google Scholar 

  • Elkind-Hirsch KE, Phillips K, Bello SM, McNicho M, de Ziegler D (2002) Sequential hormonal supplementation with vaginal estradiol and progesterone gel corrects the ffect of clomiphene on the endometrium in oligo-ovulatory women. Hum Reprod 17(2):295–298

    Article  CAS  PubMed  Google Scholar 

  • European Recombinant Human LH Study Group (1998) Recombinant human luteinizing hormone (LH) to support recombinant human follicle-stimulating hormone (FSH)-induced follicular development in LH- and FSH-deficient anovulatory women: a dose-finding study. J Clin Endocrinol Metab 83(5):1507–1514

    Google Scholar 

  • Farhi J, Orvieto R, Homburg R (2010a) Administration of clomiphene citrate in patients with polycystic ovary syndrome, without inducing withdrawal bleeding, achieves comparable treatment characteristics and outcome. Fertil Steril 93(6):2077–2079

    Article  PubMed  Google Scholar 

  • Farhi J, Orvieto R, Gavish O, Homburg R (2010b) The association between follicular size on human chorionic gonadotropin day and pregnancy rate in clomiphene citrate treated polycystic ovary syndrome patients. Gynecol Endocrinol 26(7):546–548

    Article  CAS  PubMed  Google Scholar 

  • Farquhar C, Lilford RJ, Marjoribanks J, Vandekerckhove P (2007) Laparoscopic ‚drilling‘ by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome. Cochrane Database Syst Rev (3):CD001122

    Google Scholar 

  • Fauser BC, de Jong D, Olivennes F, Wramsby H, Tay C, Itskovitz-Eldor J, van Hooren HG (2002) Endocrine profiles after triggering of final oocyte maturation with GnRH agonist after cotreatment with the GnRH antagonist ganirelix during ovarian hyperstimulation for in vitro fertilization. J Clin Endocrinol Metab 87(2):709–715

    Article  CAS  PubMed  Google Scholar 

  • Fauser BC, Nargund G, Andersen AN, Norman R, Tarlatzis B, Boivin J, Ledger W (2010) Mild ovarian stimulation for IVF: 10 years later. Hum Reprod 25(11):2678–2684

    Article  PubMed  Google Scholar 

  • Felberbaum RE, Reissmann T, Küpker W, Bauer O, al Hasani S, Diedrich C, Diedrich K (1995) Preserved pituitary response under ovarian stimulation with HMG and GnRH antagonists (Cetrorelix) in women with tubal infertility. Eur J Obstet Gynecol Reprod Biol 61(2):151–155

    Article  CAS  PubMed  Google Scholar 

  • Filicori M, Cognigni GE, Taraborrelli S, Spettoli D, Ciampaglia W, Tabarelli De Fatis C, Pocognoli P, Cantelli B, Boschi S (2001) Luteinzing hormone activity in menotropins optimizes folliculogenesis and treatment in controlled ovarian stimulation. J Clin Endocrinol Metab 86(1):337–343

    Article  CAS  PubMed  Google Scholar 

  • Flyckt RL, Goldberg JM (2011) Laparoscopic ovarian drilling for clomiphene-resistant polycystic ovary syndrome. Semin Reprod Med 29(2):138–146

    Article  PubMed  Google Scholar 

  • Franik S, Eltrop SM, Kremer JA, Kiesel L, Farquhar C (2018) Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome. Cochrane Database Syst Rev (5):CD010287

    Google Scholar 

  • Freiesleben NL, Lossl K, Bogstad J, Bredkjaer HE, Toft B, Loft A, Bangsboll S, Pinborg A, Budtz-Jørgensen E, Andersen AN (2008) Predictors of ovarian response in intrauterine insemination patients and development of a dosage nomogram. Reprod Biomed Online 17(5):632–641

    Article  CAS  PubMed  Google Scholar 

  • Galazis N, Zertalis M, Haoula Z, Atiomo W (2011) Is ultrasound monitoring of the ovaries during ovulation induction by clomiphene citrate essential? A systematic review. J Obstet Gynaecol 31(7):566–571

    Article  CAS  PubMed  Google Scholar 

  • Gonen Y, Balakier H, Powell W, Casper RF (1990) Use of gonadotropin-releasing hormone agonist to trigger follicular maturation for in vitro fertilization. J Clin Endocrinol Metab 71(4):918–922

    Article  CAS  PubMed  Google Scholar 

  • Green KA, Zolton JR, Schermerhorn SM, Lewis TD, Healy MW, Terry N, DeCherney AH, Hill MJ (2017) Progesterone luteal support after ovulation induction and intrauterine insemination: an updated systematic review and meta-analysis. Fertil Steril 107(4):924–933.e5

    Article  CAS  PubMed  Google Scholar 

  • Griesinger G, Felberbaum RE, Schultze-Mosgau A, Diedrich K (2004) Gonadotropin-releasing hormone antagonists for assisted reproductive techniques: are there clinical differences between agents? Drugs 64(6):563–575

    Article  CAS  PubMed  Google Scholar 

  • Griesinger G, Diedrich K, Tarlatzis B, Kolibianakis EM (2006) GnRH-antagonists in ovarian stimulation for IVF in patients with [1] poor response to gonadotrophins, [2] polycystic ovary syndrome, and [3] risk of ovarian hyperstimulation: a meta-analysis. Reprod BioMed Online 13(5):628–638

    Article  CAS  PubMed  Google Scholar 

  • Griesinger G, von Otte S, Schroer A, Ludwig AK, Diedrich K, Al-Hasani S, Schultze-Mosgau A (2007) Elective cryopreservation of all pronuclear oocytes after GnRH agonist triggering of final oocyte maturation in patients at risk of developing OHSS: a prospective, observational proof-of-concept study. Hum Reprod 22(5):1348–1352

    Article  CAS  PubMed  Google Scholar 

  • Griesinger G, von Otte S, Schultze-Mosgau A, Diedrich K, Schröer A (2009) Follicular and endocrine response to anastrozole versus clomiphene citrate administered in follicular phase to normoovulatory women: a randomized comparison. Fertil Steril 91(5):1831–1836

    Article  CAS  PubMed  Google Scholar 

  • Griesinger G, Shapiro DB, Kolibianakis EM, Witjes H, Mannaerts BM (2011a) No association between endogenous LH and pregnancy in a GnRH antagonist protocol: part II, recombinant FSH. Reprod BioMed Online 23(4):457–465

    Article  CAS  PubMed  Google Scholar 

  • Griesinger G, Schultz L, Bauer T, Broessner A, Frambach T, Kissler S (2011b) Ovarian hyperstimulation syndrome prevention by gonadotropin-releasing hormone agonist triggering of final oocyte maturation in a gonadotropin-releasing hormone antagonist protocol in combination with a „freeze-all“ strategy: a prospective multicentric study. Fertil Steril 95(6):2029–2033, 2033.e1

    Article  CAS  PubMed  Google Scholar 

  • Griesinger G, Mannaerts B, Andersen CY, Witjes H, Kolibianakis EM, Gordon K (2013) Progesterone elevation does not compromise pregnancy rates in high responders: a pooled analysis of in vitro fertilization patients treated with recombinant follicle-stimulating hormone/gonadotropin-releasing hormone antagonist in six trials. Fertil Steril 100(6):1622–1628

    Article  CAS  PubMed  Google Scholar 

  • Griesinger G, Verweij PJ, Gates D, Devroey P, Gordon K, Stegmann BJ, Tarlatzis BC (2016) Prediction of ovarian hyperstimulation syndrome in patients treated with corifollitropin alfa or rFSH in a GnRH antagonist protocol. PLoS One 11(3):e0149615

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Healy DL, Trounson AO, Nyboe Andersen A (1994) Female infertility: causes and treatment. Lancet 343:1539–1544

    Article  CAS  PubMed  Google Scholar 

  • Hendriks ML, van der Valk P, Lambalk CB, Broeckaert MA, Homburg R, Hompes PG (2010) Extensive tissue damage of bovine ovaries after bipolar ovarian drilling compared to monopolar electrocoagulation or carbon dioxide laser. Fertil Steril 93(3):969–975

    Article  PubMed  Google Scholar 

  • Hillier SG, Whitelaw PF, Smyth CD (1993) Follicular oestrogen synthesis: the ‚two-cell, two-gonadotropin‘ model revisited. Mol Cell Endocrinol 100:51–54

    Article  CAS  PubMed  Google Scholar 

  • Hohmann FP, Laven JS, Mulders AG, Oberyé JJ, Mannaerts BM, de Jong FH, Fauser BC (2005) LH suppression following different low doses of the GnRH antagonist ganirelix in polycystic ovary syndrome. J Endocrinol Investig 28(11):990–997

    Article  CAS  Google Scholar 

  • Homburg R (2005) Clomiphene citrate – end of an era? A mini-review. Hum Reprod 20(8):2043–2051

    Article  CAS  PubMed  Google Scholar 

  • Homburg R, Howles CM (1999) Low-dose FSH therapy for anovulatory infertility associated with polycystic ovary syndrome: rationale, results, reflections and refinements. Hum Reprod Update 5(5):493–499

    Article  CAS  PubMed  Google Scholar 

  • Homburg R, Hendriks ML, König TE, Anderson RA, Balen AH, Brincat M, Child T, Davies M, D’Hooghe T, Martinez A, Rajkhowa M, Rueda-Saenz R, Hompes P, Lambalk CB (2012) Clomifene citrate or low-dose FSH for the first-line treatment of infertile women with anovulation associated with polycystic ovary syndrome: a prospective randomized multinational study. Hum Reprod 27(2):468–473

    Article  CAS  PubMed  Google Scholar 

  • Hooff MH van, Alberda AT, Huisman GJ, Zeilmaker GH, Leerentveld RA (1993) Doubling the human menopausal gonadotrophin dose in the course of an in-vitro fertilization treatment cycle in low responders: a randomized study. Hum Reprod 8:369–373

    Google Scholar 

  • Hughes E, Brown J, Collins JJ, Vanderkerchove P (2010) Clomiphene citrate for unexplained subfertility in women. Cochrane Database Syst Rev (1):CD000057

    Google Scholar 

  • Hugues JN, Soussis J, Calderon I, Balasch J, Anderson RA, Romeu A (2005) Recombinant LH Study Group. Does the addition of recombinant LH in WHO group II anovulatory women over-responding to FSH treatment reduce the number of developing follicles? A dose-finding study. Hum Reprod 20(3):629–635

    Article  CAS  PubMed  Google Scholar 

  • Humaidan P, Papanikolaou EG, Kyrou D, Alsbjerg B, Polyzos NP, Devroey P, Fatemi HM (2012) The luteal phase after GnRH-agonist triggering of ovulation: present and future perspectives. Reprod Biomed Online 24(2):134–141

    Article  CAS  PubMed  Google Scholar 

  • Imani B, Eijkemans MJ, Faessen GH, Bouchard P, Giudice LC, Fauser BC (2002a) Prediction of the individual follicle-stimulating hormone threshold for gonadotropin induction of ovulation in normogonadotropic anovulatory infertility: an approach to increase safety and efficiency. Fertil Steril 77(1):83–90

    Article  PubMed  Google Scholar 

  • Imani B, Eijkemans MJ, te Velde ER, Habbema JD, Fauser BC (2002b) A nomogram to predict the probability of live birth after clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility. Fertil Steril 77(1):91–97

    Article  PubMed  Google Scholar 

  • Klinkert ER, Broekmans FJ, Looman CW, Habbema JD, te Velde ER (2005) Expected poor responders on the basis of an antral follicle count do not benefit from a higher starting dose of gonadotrophins in IVF treatment: a randomized controlled trial. Hum Reprod 20(3):611–615

    Article  CAS  PubMed  Google Scholar 

  • Kol S (2004) Luteolysis induced by a gonadotropin-releasing hormone agonist is the key to prevention of ovarian hyperstimulation syndrome. Fertil Steril 81(1):1–5

    Article  CAS  PubMed  Google Scholar 

  • Kolibianakis EM, Zikopoulos KA, Fatemi HM, Osmanagaoglu K, Evenpoel J, Van Steirteghem A, Devroey P (2004a) Endometrial thickness cannot predict ongoing pregnancy achievement in cycles stimulated with clomiphene citrate for intrauterine insemination. Reprod Biomed Online 8(1):115–118

    Article  CAS  PubMed  Google Scholar 

  • Kolibianakis EM, Albano C, Camus M, Tournaye H, Van Steirteghem AC, Devroey P (2004b) Prolongation of the follicular phase in in vitro fertilization results in a lower ongoing pregnancy rate in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists. Fertil Steril 82(1):102–107

    Article  CAS  PubMed  Google Scholar 

  • Kolibianakis EM, Collins J, Tarlatzis BC, Devroey P, Diedrich K, Griesinger G (2006) Among patients treated for IVF with gonadotrophins and GnRH analogues, is the probability of live birth dependent on the type of analogue used? A systematic review and meta-analysis. Hum Reprod Update 12(6):651–671

    Article  CAS  PubMed  Google Scholar 

  • Kolibianakis EM, Griesinger G, Venetis CA (2012) GnRH agonist for triggering final oocyte maturation: time for a critical evaluation of data. Hum Reprod Update 18(2):228–229

    Article  CAS  PubMed  Google Scholar 

  • Kolibianakis EM, Griesinger G, Venetis CA (2017) GnRH antagonists vs. long GnRH agonists in IVF: significant flaws in a meta-analysis lead to invalid conclusions. Hum Reprod Update. https://doi.org/10.1093/humupd/dmx037

    Article  Google Scholar 

  • Kosmas IP, Tatsioni A, Fatemi HM, Kolibianakis EM, Tournaye H, Devroey P (2007) Human chorionic gonadotropin administration vs. luteinizing monitoring for intrauterine insemination timing, after administration of clomiphene itrate: a meta-analysis. Fertil Steril 87(3):607–612

    Article  CAS  PubMed  Google Scholar 

  • Kosmas IP, Tatsioni A, Kolibianakis EM, Verpoest W, Tournaye H, Van der Elst J, Devroey P (2008) Effects and clinical significance of GnRH antagonist administration for IUI timing in FSH superovulated cycles: a meta-analysis. Fertil Steril 90(2):367–372

    Article  PubMed  Google Scholar 

  • Kousta E, White DM, Franks S (1997) Modern use of clomiphene citrate in induction of ovulation. Hum Reprod Update 3(4):359–365

    Article  CAS  PubMed  Google Scholar 

  • Kyrou D, Popovic-Todorovic B, Fatemi HM, Bourgain C, Haentjens P, Van Landuyt L, Devroey P (2009) Does the estradiol level on the day of human chorionic gonadotrophin administration have an impact on pregnancy rates in patients treated with rec-FSH/GnRH antagonist? Hum Reprod 24(11):2902–2909

    Article  CAS  PubMed  Google Scholar 

  • Kyrou D, Fatemi HM, Tournaye H, Devroey P (2010) Luteal phase support in normo-ovulatory women stimulated with clomiphene citrate for intrauterine insemination: need or habit? Hum Reprod 25(10):2501–2506

    Article  CAS  PubMed  Google Scholar 

  • La Marca A, Giulini S, Tirelli A, Bertucci E, Marsella T, Xella S, Volpe A (2007) Anti-Müllerian hormone measurement on any day of the menstrual cycle strongly predicts ovarian response in assisted reproductive technology. Hum Reprod 22(3):766–771

    Article  PubMed  CAS  Google Scholar 

  • Labarta E, Martínez-Conejero JA, Alamá P, Horcajadas JA, Pellicer A, Simón C, Bosch E (2011) Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod 26(7):1813–1825

    Article  CAS  PubMed  Google Scholar 

  • Legro RS, Barnhart HX, Schlaff WD, Carr BR, Diamond MP, Carson SA, Steinkampf MP, Coutifaris C, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Giudice LC, Leppert PC, Myers ER, Cooperative Multicenter Reproductive Medicine Network (2007) Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. N Engl J Med 356(6):551–566

    Article  CAS  PubMed  Google Scholar 

  • Legro RS, Brzyski RG, Diamond MP, Coutifaris C, Schlaff WD, Casson P, Christman GM, Huang H, Yan Q, Alvero R, Haisenleder DJ, Barnhart KT, Bates GW, Usadi R, Lucidi S, Baker V, Trussell JC, Krawetz SA, Snyder P, Ohl D, Santoro N, Eisenberg E, Zhang H, NICHD Reproductive Medicine Network (2014) Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. N Engl J Med 371(2):119–129

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lerman T, Depenbusch M, Schultze-Mosgau A, von Otte S, Scheinhardt M, Koenig I, Kamischke A, Macek M, Schwennicke A, Segerer S, Griesinger G (2017) Ovarian response to 150 μg corifollitropin alfa in a GnRH-antagonist multiple-dose protocol: a prospective cohort study. Reprod Biomed Online 34(5):534–540

    Article  CAS  PubMed  Google Scholar 

  • López E, Gunby J, Daya S, Parrilla JJ, Abad L, Balasch J (2004) Ovulation induction in women with polycystic ovary syndrome: randomized trial of clomiphene citrate versus low-dose recombinant FSH as first line therapy. Reprod Biomed Online 9(4):382–390

    Article  PubMed  Google Scholar 

  • Loumaye E (1990) The control of endogenous secretion of LH by gonadotrophin-releasing hormone agonists during ovarian hyperstimulation for in-vitro fertilization and embryo transfer. Hum Reprod 5(4):357–376

    Article  CAS  PubMed  Google Scholar 

  • Ludwig M, Katalinic A, Banz C, Schröder AK, Löning M, Weiss JM, Diedrich K (2002) Tailoring the GnRH antagonist cetrorelix acetate to individual patients’ needs in ovarian stimulation for IVF: results of a prospective, randomized study. Hum Reprod 17(11):2842–2845

    Article  CAS  PubMed  Google Scholar 

  • Mannaerts B, on behalf The corifollitropin alfa Ensure study group (2010) Corifollitropin alfa for ovarian stimulation in IVF: a randomized trial in lower-body-weight women. Reprod Biomed Online 21:66–76

    Article  CAS  Google Scholar 

  • Mannaerts BM, Rombout F, Out HJ, Coelingh Bennink H (1996) Clinical profiling of recombinant follicle stimulating hormone (rFSH; Puregon): relationship between serum FSH and efficacy. Hum Reprod Update 2(2):153–161

    Article  CAS  PubMed  Google Scholar 

  • Martinez AR, Bernardus RE, Voorhorst FJ, Vermeiden JP, Schoemaker J (1991) Pregnancy rates after timed intercourse or intrauterine insemination after human menopausal gonadotropin stimulation of normal ovulatory cycles: a controlled study. Fertil Steril 55(2):258–265

    Article  CAS  PubMed  Google Scholar 

  • Matorras R, Ramón O, Expósito A, Corcóstegui B, Ocerin I, Gonzalez-Lopera S, Rodríguez-Escudero FJ (2006) Gn-RH antagonists in intrauterine insemination: the weekend-free protocol. J Assist Reprod Genet 23(2):51–54

    Article  PubMed  PubMed Central  Google Scholar 

  • Nahuis MJ, Kose N, Bayram N, van Dessel HJ, Braat DD, Hamilton CJ, Hompes PG, Bossuyt PM, Mol BW, van der Veen F, van Wely M (2011) Long-term outcomes in women with polycystic ovary syndrome initially randomized to receive laparoscopic electrocautery of the ovaries or ovulation induction with gonadotrophins. Hum Reprod 26(7):1899–1904

    Article  CAS  PubMed  Google Scholar 

  • Nargund G, Reid F, Parsons J (2001) Human chorionic gonadotropin-to-oocyte collection interval in a superovulation IVF program. A prospective study. J Assist Reprod Genet 18(2):87–90

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nargund G, Fauser BC, Macklon NS, Ombelet W, Nygren K, Frydman R, Rotterdam ISMAAR Consensus Group on Terminology for Ovarian Stimulation for IVF (2007) The ISMAAR proposal on terminology for ovarian stimulation for IVF. Hum Reprod 22(11):2801–2804

    Article  CAS  PubMed  Google Scholar 

  • Nelson SM, Yates RW, Lyall H, Jamieson M, Traynor I, Gaudoin M, Mitchell P, Ambrose P, Fleming R (2009) Anti-Müllerian hormone-based approach to controlled ovarian stimulation for assisted conception. Hum Reprod 24(4):867–875

    Article  CAS  PubMed  Google Scholar 

  • Norman RJ, Zegers-Hochschild F, Salle BS, Elbers J, Heijnen E, Marintcheva-Petrova M, Mannaerts B, Investigators T (2011) Repeated ovarian stimulation with corifollitropin alfa in patients in a GnRH antagonist protocol: no concern for immunogenicity. Hum Reprod 26(8):2200–2208

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nyboe Andersen A, Balen A, Platteau P, Devroey P, Helmgaard L, Arce JC (2008) Bravelle Ovulation Induction (BOI) Study Group. Predicting the FSH threshold dose in women with WHO Group II anovulatory infertility failing to ovulate or conceive on clomiphene citrate. Hum Reprod 23(6):1424–1430

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nyboe Andersen A, Nelson SM, Fauser BC, García-Velasco JA, Klein BM, Arce JC (2017) ESTHER-1 study group. Individualized versus conventional ovarian stimulation for in vitro fertilization: a multicenter, randomized, controlled, assessor-blinded, phase 3 noninferiority trial. Fertil Steril 107(2):387–396.e4. https://doi.org/10.1016/j.fertnstert.2016.10.033

    Article  PubMed  CAS  Google Scholar 

  • Oehninger S, Nelson SM, Verweij P, Stegmann BJ (2015) Predictive factors for ovarian response in a corifollitropin alfa/GnRH antagonist protocol for controlled ovarian stimulation in IVF/ICSI cycles. Reprod Biol Endocrinol 13:117. https://doi.org/10.1186/s12958-015-0113-1

  • Olivennes F, Howles CM, Borini A, Germond M, Trew G, Wikland M, Zegers-Hochschild F, Saunders H, Alam V, CONSORT Study Group (2009) Individualizing FSH dose for assisted reproduction using a novel algorithm: the CONSORT study. Reprod Biomed Online 18(2):195–204

    Google Scholar 

  • Olivius C, Friden B, Borg G, Bergh C (2004) Why do couples discontinue in vitro fertilization treatment? A cohort study. Fertil Steril 81(2):258–261

    Article  PubMed  Google Scholar 

  • Papanikolaou EG, Pozzobon C, Kolibianakis EM, Camus M, Tournaye H, Fatemi HM, Van Steirteghem A, Devroey P (2006) Incidence and prediction of ovarian hyperstimulation syndrome in women undergoing gonadotropin-releasing hormone antagonist in vitro fertilization cycles. Fertil Steril 85(1):112–120

    Article  CAS  PubMed  Google Scholar 

  • Pauli JM, Raja-Khan N, Wu X, Legro RS (2011) Current perspectives of insulin resistance and polycystic ovary syndrome. Diabet Med 28(12):1445–1454

    Article  CAS  PubMed  Google Scholar 

  • Polyzos NP, Tzioras S, Badawy AM, Valachis A, Dritsas C, Mauri D (2009) Aromatase inhibitors for female infertility: a systematic review of the literature. Reprod Biomed Online 19(4):456–471

    Article  CAS  PubMed  Google Scholar 

  • Popovic-Todorovic B, Loft A, Bredkjaeer HE, Bangsbøll S, Nielsen IK, Andersen AN (2003a) A prospective randomized clinical trial comparing an individual dose of recombinant FSH based on predictive factors versus a ‚standard‘ dose of 150 IU/day in ‚standard‘ patients undergoing IVF/ICSI treatment. Hum Reprod 18(11):2275–2282

    Article  CAS  PubMed  Google Scholar 

  • Popovic-Todorovic B, Loft A, Lindhard A, Bangsbøll S, Andersson AM, Andersen AN (2003b) A prospective study of predictive factors of ovarian response in ‚standard‘ IVF/ICSI patients treated with recombinant FSH. A suggestion for a recombinant FSH dosage normogram. Hum Reprod 18(4):781–787

    Article  CAS  PubMed  Google Scholar 

  • Randall JM, Templeton A (1992) Cervical mucus score and in vitro sperm mucus interaction in spontaneous and clomiphene citrate cycles. Fertil Steril 56:465–468

    Article  Google Scholar 

  • Reefhuis J, Honein MA, Schieve LA, Rasmussen SA (2011) National Birth Defects Prevention Study. Use of clomiphene citrate and birth defects, National Birth Defects Prevention Study, 1997–2005. Hum Reprod 26(2):451–457

    Article  CAS  PubMed  Google Scholar 

  • Richmond JR, Deshpande N, Lyall H, Yates RW, Fleming R (2005) Follicular diameters in conception cycles with and without multiple pregnancy after stimulated ovulation induction. Hum Reprod 20(3):756–760

    Article  CAS  PubMed  Google Scholar 

  • Rombauts L (2007) Is there a recommended maximum starting dose of FSH in IVF? J Assist Reprod Genet 24(8):343–349

    Article  PubMed  PubMed Central  Google Scholar 

  • Rumste MM van, Custers IM, van der Veen F, van Wely M, Evers JL, Mol BW (2008) The influence of the number of follicles on pregnancy rates in intrauterine insemination with ovarian stimulation: a meta-analysis. Hum Reprod Update 14(6):563–570

    Google Scholar 

  • Santbrink EJ van, Eijkemans MJ, Macklon NS, Fauser BC (2002) FSH response-dose can be predicted in ovulation induction for normogonadotropic anovulatory infertility. Eur J Endocrinol; 147 (2): 223–226

    Google Scholar 

  • Scheinhardt MO, Lerman T, König IR, Griesinger G (2018) Performance of prognostic modelling of high and low ovarian response to ovarian stimulation for IVF. Hum Reprod. https://doi.org/10.1093/humrep/dey236

    Article  CAS  PubMed  Google Scholar 

  • Schill T (2011) Daten zur konservativen Fertiltätstherapie. DVR Kongress 2011

    Google Scholar 

  • Schmidt TW, Maier DB, Nulsen JC, Benadiva CA (2004) Reducing the dose of human chorionic gonadotropin in high responders does not affect the outcomes of in vitro fertilization. Fertil Steril 82(4):841–846

    Article  CAS  PubMed  Google Scholar 

  • Schoot DC, Hop WC, de Jong FH, van Dessel TJ, Fauser BC (1995) Initial estradiol response predicts outcome of exogenous gonadotropins using a step-down dose regimen for induction of ovulation in polycystic ovary syndrome. Fertil Steril 64(6):1081–1087

    Article  CAS  PubMed  Google Scholar 

  • Shoham Z, Balen A, Patel A, Jacobs HS (1991) Results of ovulation induction using human menopausal gonadotropin or purified follicle-stimulating hormone in hypogonadotropic hypogonadism patients. Fertil Steril 56(6):1048–1053

    Article  CAS  PubMed  Google Scholar 

  • Steptoe PC, Edwards RG (1978) Birth after the reimplantation of a human embryo. Lancet II:366

    Article  Google Scholar 

  • Sunkara SK, Rittenberg V, Raine-Fenning N, Bhattacharya S, Zamora J, Coomarasamy A (2011) Association between the number of eggs and live birth in IVF treatment: an analysis of 400 135 treatment cycles. Hum Reprod 26:1768–1774

    Article  PubMed  Google Scholar 

  • Tan SL, Balen A, el Hussein E, Mills C, Campbell S, Yovich J, Jacobs HS (1992) A prospective randomized study of the optimum timing of human chorionic gonadotropin administration after pituitary desensitization in in vitro fertilization. Fertil Steril 57(6):1259–1264

    Article  CAS  PubMed  Google Scholar 

  • Tang T, Lord JM, Norman RJ, Yasmin E, Balen AH (2010) Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database Syst Rev (1):CD003053

    Google Scholar 

  • Tarlatzis B, Griesinger G, Leader A, Rombauts R, IJzerman-Boon P, Mannaerts B, on behalf of all investigators participating in the Engage, Ensure or Trust trials (2012) Comparative incidence of ovarian hyperstimulation syndrome following ovarian stimulation with corifollitropin alfa or recombinant FSH. Reprod Biomed Online 24(4):410–419. [Epub 2012 Jan 24]

    Article  CAS  PubMed  Google Scholar 

  • Tavaniotou A, Albano C, Smitz J, Devroey P (2002) Impact of ovarian stimulation on corpus luteum function and embryonic implantation. J Reprod Immunol 55(1–2):123–130

    Article  CAS  PubMed  Google Scholar 

  • Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L, Piltonen T, Norman RJ (2018) International PCOS Network. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Hum Reprod 33(9):1602–1618

    Article  PubMed  PubMed Central  Google Scholar 

  • Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group (2008) Consensus on infertility treatment related to polycystic ovary syndrome. Hum Reprod 23(3):462–477. Erratum in: Hum Reprod 2008; 23(6):1474

    Article  Google Scholar 

  • Thornton SJ, Pantos C, Speirs A, Johnston I (1990) Human chorionic gonadotropin to oocyte retrieval interval in in vitro fertilization – how critical is it? Fertil Steril 53(1):177–179

    Article  CAS  PubMed  Google Scholar 

  • Tredway DR, Schertz JC (2011) Anastrozole versus clomiphene citrate: which is better for ovulation induction? Fertil Steril 95(5):1549–1551

    Article  CAS  PubMed  Google Scholar 

  • Trounson AO, Leeton JF, Wood C et al (1981) Pregnancies in humans by fertilization in vitro and embryo transfer in the controlled ovulatory cycle. Science 212(4495):681–682

    Article  CAS  PubMed  Google Scholar 

  • Tulandi T, Martin J, Al-Fadhli R, Kabli N, Forman R, Hitkari J, Librach C, Greenblatt E, Casper RF (2006) Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate. Fertil Steril 85(6):1761–1765

    Article  CAS  PubMed  Google Scholar 

  • Veltman-Verhulst SM, Fauser BC, Eijkemans MJ (2012) High singleton live birth rate confirmed after ovulation induction in women with anovulatory polycystic ovary syndrome: validation of a prediction model for clinical practice. Fertil Steril 98(3):761–768.e1. https://doi.org/10.1016/j.fertnstert.2012.04.027

    Article  PubMed  Google Scholar 

  • Venetis CA, Kolibianakis EM, Bosdou JK, Tarlatzis BC (2013) Progesterone elevation and probability of pregnancy after IVF: a systematic review and meta-analysis of over 60.000 cycles. Hum Reprod Update 19(5):433–457

    Article  CAS  PubMed  Google Scholar 

  • Weiss NS, Nahuis MJ, Bordewijk E, Oosterhuis JE, Smeenk JM, Hoek A, Broekmans FJ, Fleischer K, de Bruin JP, Kaaijk EM, Laven JS, Hendriks DJ, Gerards MH, van Rooij IA, Bourdrez P, Gianotten J, Koks C, Lambalk CB, Hompes PG, van der Veen F, Mol BWJ, van Wely M (2018) Gonadotrophins versus clomifene citrate with or without intrauterine insemination in women with normogonadotropic anovulation and clomifene failure (M-OVIN): a randomised, two-by-two factorial trial. Lancet 391(10122):758–765

    Article  CAS  Google Scholar 

  • Weissenbruch MM van, Schoemaker HC, Drexhage HA, Schoemaker J (1993) Pharmaco-dynamics of human menopausal gonadotrophin (HMG) and follicle-stimulating hormone (FSH). The importance of the FSH concentration in initiating follicular growth in polycystic ovary-like disease. Hum Reprod 8(6):813–821

    Google Scholar 

  • Wely M van, Bayram N, van der Veen F, Bossuyt PM (2004) An economic comparison of a laparoscopic electrocautery strategy and ovulation induction with recombinant FSH in women with clomiphene citrate-resistant polycystic ovary syndrome. Hum Reprod 19(8):1741–1745

    Google Scholar 

  • Wely M van, Fauser BC, Laven JS, Eijkemans MJ, van der Veen F (2006) Validation of a prediction model for the follicle-stimulating hormone response dose in women with polycystic ovary syndrome. Fertil Steril 86(6):1710–1715

    Google Scholar 

  • White DM, Polson DW, Kiddy D, Sagle P, Watson H, Gilling-Smith C, Hamilton-Fairley D, Franks S (1996) Induction of ovulation with low-dose gonadotropins in polycystic ovary syndrome: an analysis of 109 pregnancies in 225 women. J Clin Endocrinol Metab 81(11):3821–3824

    CAS  PubMed  Google Scholar 

  • Wikland M, Borg J, Forsberg AS, Jakobsson AH, Svalander P, Waldenström U (1995) Human chorionic gonadotrophin self-administered by the subcutaneous route to induce oocyte maturation in an in-vitro fertilization and embryo transfer programme. Hum Reprod 10(7):1667–1670

    Article  CAS  PubMed  Google Scholar 

  • Youssef MA, Van der Veen F, Al-Inany HG, Mochtar MH, Griesinger G, Nagi Mohesen M, Aboulfoutouh I, van Wely M (2014) Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering in antagonist-assisted reproductive technology. Cochrane Database Syst Rev (10):CD008046

    Google Scholar 

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Griesinger, G. (2020). Ovulationsinduktion und ovarielle Stimulation. In: Diedrich, K., Ludwig, M., Griesinger, G. (eds) Reproduktionsmedizin. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-57636-6_15

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