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Pharmakokinetik und Arzneimittelinteraktionen

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Kompendium der Psychiatrischen Pharmakotherapie
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Zusammenfassung

Hintergründe zur Pharmakokinetik und zu Interaktionen werden dargestellt. Alle in der Psychopharmakotherapie relevanten Wechselwirkungen werden in Anhang INT und Anhang SUB ausführlich so aufgeführt, dass der Leser die einzelnen Risiken selbst nachvollziehen kann. Der Bezug zu den Angaben bei den einzelnen Präparaten wird hergestellt.

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Literatur

  • Barski OA, Tipparaju SM, Bhatnagar A (2016) The aldo-keto reductase superfamily and its role in drug metabolism and detoxification. Drug Metab Rev. 40: 553–624

    Article  CAS  Google Scholar 

  • Brückl TM, Uhr M (2016) ABCB1 genotyping in the treatment of depression. Pharmacogenomics 17(18): 2039–2069

    Article  Google Scholar 

  • Breitenstein B, Scheuer S, Brückl TM et al (2016) Association of ABCB1 gene variants, plasma antidepressant concentration, and treatment response: Results from a randomized clinical study. J Psychiatr Res 73: 86–95

    Article  Google Scholar 

  • Faber MS, Fuhr U (2004) Time response of cytochrome P450 1A2 activity on cessation of heavy smoking. Clin Pharmacol Ther 76: 178–184

    Article  CAS  Google Scholar 

  • Gründer G, Baumann P, Conca A et al; für die TDM-Gruppe der AGNP (2014) Therapeutisches Drug-Monitoring in der Psychiatrie. 85: 847855

    Google Scholar 

  • Haen E (2014) Arzneimittelinteraktionen. Nervenarzt 85: 417–426

    Article  CAS  Google Scholar 

  • Hicks JK, Swen JJ, Thorn CF et al (2013) Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants. Clin Pharmacol Ther 93: 402–408

    Article  CAS  Google Scholar 

  • Hicks JK, Bishop JR, Sangkuhl K et al; Clinical Pharmacogenetics Implementation Consortium (2015) Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther 98: 127–134

    Google Scholar 

  • Hiemke C, Eckermann G (2014) Kombinationstherapie/Polypharmazie: Interaktionen von Psychopharmaka. Psychopharmakotherapie 21: 269–279

    Google Scholar 

  • Hiemke C, Bergemann N, Clement HW et al (2018) Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017. Pharmacopsychiatry 51: 9–62

    Google Scholar 

  • Jukić MM, Haslemo T, Molden E et al (2018) Impact of CYP2C19 genotype on escitalopram exposure and therapeutic failure: a retrospective study based on 2,087 patients. Am J Psychiatry 175: 463–470

    Article  Google Scholar 

  • Oda S, Fukami T, Yokoi T et al (2015) A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development. Drug Metab Pharmacokinet 30: 30–51

    Article  CAS  Google Scholar 

  • Ostad Haji E, Tadic A, Wagner S et al (2013) Early improvement and serum concentrations of citalopram to predict antidepressant drug response of patients with major depression. Pharmacopsychiatry 46: 261–266

    Article  CAS  Google Scholar 

  • Schatzberg AF, DeBattista, Lazzeroni LC et al (2015) ABCB1 genetic effects on antidepressant outcomes: a report from the iSPOT-D trial. Am J Psychiatry 172: 751–159

    Article  Google Scholar 

  • Stingl J, Viviani R (2015) Polymorphism in CYP2D6 and CYP2C19, members of the cytochrome P450 mixed-function oxidase system, in the metabolism of psychotropic drugs. J Intern Med 277(2): 167–177

    Article  CAS  Google Scholar 

  • Zanger UM, Schwab M (2013) Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Therapeutics 138: 103–141

    Article  CAS  Google Scholar 

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Correspondence to C. Hiemke or O. Benkert .

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Hiemke, C., Benkert, O. (2019). Pharmakokinetik und Arzneimittelinteraktionen. In: Benkert, O., Hippius, H. (eds) Kompendium der Psychiatrischen Pharmakotherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-57334-1_16

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  • DOI: https://doi.org/10.1007/978-3-662-57334-1_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-57333-4

  • Online ISBN: 978-3-662-57334-1

  • eBook Packages: Medicine (German Language)

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